Sensory Augmentation, Restoration, and Modulation Using a Spinal Neuroprosthesis

使用脊柱神经假体进行感觉增强、恢复和调节

• 批准号: 10687329
• 负责人: Amol P Yadav
• 金额: $ 137.97万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-07 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687329
• 关键词: Acceleration; Address; Affect; American; Amputees; Animals; Brain; Clinical; Cues; Development; Devices; Disease; Electromagnetics; Environment; Esthesia; FDA approved; Feasibility Studies; Goals; Human; Individual; Injury; Intuition; Just-Noticeable Differences; Learning; Life; Limb Prosthesis; Location; Locomotion; Lower Extremity; Macaca mulatta; Methods; Movement; Nervous System Trauma; Neurologic; Neurostimulation procedures of spinal cord tissue; Numbness; Patients; Perception; Quality of life; Rehabilitation therapy; Research; Research Personnel; Rodent; Sensory; Signal Transduction; Spinal; Spinal Cord; Spinal cord injury; Stroke; Technology; Testing; Time; Training; Traumatic Brain Injury; Ultraviolet Rays; Variant; Vertebral column; brain machine interface; chronic pain management; clinical translation; experimental study; human subject; implantation; infancy; innovation; limb amputation; magnetic field; motor control; nervous system disorder; neuroprosthesis; non-Native; novel; pre-clinical; prevent; restoration; sensory feedback; standard of care; transmission process

Project Summary The physical world contains signals encompassing the entire electromagnetic spectrum, and yet human perception of the world is limited to our five senses. To augment our senses, it is essential to first develop methods that can effectively transmit high-bandwidth information to the brain. Researchers working on brain- machine interfaces have successfully extracted movement signals from the brain to control external devices. Yet, methods that augment, restore, or modulate sensory perception are currently limited. Lack of real-time sensory feedback from a brain-machine interface or neuroprosthetic device prevents optimal motor control and thus limits sensorimotor rehabilitation. Loss of sensation due to life-altering injuries and disorders affects the quality of life of millions of Americans. Thus, methods that mimic sensory signals and interface them directly with the brain are an unmet clinical need. This project proposes a novel spinal sensory neuroprosthetic interface using sensory spinal cord stimulation (SSCS) with the ability to augment, restore, and modulate sensory perceptions. This radically innovative approach has the potential to impact a wide array of neurological conditions by addressing sensory restoration and allows for the exploration of the limits of human sensory perception. Pre- clinical experiments in rodents and rhesus monkeys demonstrated that animals learn to detect and discriminate artificial sensations induced by SSCS. To achieve clinical translation of SSCS technology, this proposal involves a feasibility study, conducted in patients undergoing spinal cord stimulator implantation for the treatment of chronic pain. First, the relationship between SSCS-induced sensory perceptual thresholds, just-noticeable differences, and stimulation parameters will be established (Goal 1). Second, human subjects will be trained to detect and discriminate variations in signal intensity and orientation of non-native signals such as infrared, UV light, magnetic fields, etc. using SSCS-induced perceptual sense, and ultimately subjects will learn to use these novel perceptual abilities to navigate a spatial environment with non-native signal cues (Goal 2). Third, lower limb amputee subjects will learn to intuitively perceive movement and location of their prosthetic limbs during locomotion via real-time closed loop sensory feedback using SSCS (Goal 3). This project is innovative because it uses FDA-approved technology (spinal cord stimulation) in a new context, all without changing the patient’s standard-of-care. The ability to augment, restore, and modulate perceptions will be an unprecedented development in the field of sensory neuroprosthetics. Successful execution of proposed goals will not only launch a new line of augmentation research, but it will also showcase that SSCS can be widely applicable in the rehabilitation of patients suffering from sensory deficits due to neurological disorders and injuries.

项目总结