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Ingestible gastric-resident electronic metamaterials architecture (iGEM) for the treatment of obesity

用于治疗肥胖症的可摄入胃驻留电子超材料架构（iGEM）

基本信息

批准号：
10688246
负责人：
YONG LIN KONG
金额：
$ 34.28万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688246
关键词：
3-Dimensional 3D Print Abdominal Pain Adult Affect Air Animal Model Architecture Biochemical Body Weight Body Weight decreased Cardiovascular Diseases Chemicals Chronic Disease Clinical Clinical Research Complex Consumption Data Devices Diabetes Mellitus Dissociation Doctor of Philosophy Dosage Forms Effectiveness Electric Capacitance Electronics Eligibility Determination Endoscopy Environment Excision Excretory function Feedback Feeling Foundations Gastric Balloon Goals Healthcare Hybrids Hypertension Implant Intervention Intestinal Obstruction Magnetism Measurement Measures Mechanics Metabolic Methodology Monitor Morbidity - disease rate Nausea Obesity Obesity associated disease Operative Surgical Procedures Oral Oral Ingestion Outcome Patient Selection Patients Perforation Performance Printing Quality of life Reflux Reporting Research Risk Risk Factors Rupture Safety Saline Satiation Serious Adverse Event Stents Stomach Structure System Temperature Time Treatment Effectiveness Ulcer Vomiting Work bariatric surgery biomaterial compatibility cost design digital experience gastrointestinal symptom improved invention novel obesity treatment porcine model premature pressure pressure sensor prevent programs rational design residence sensor simulation treatment strategy wireless wireless sensor

项目摘要

Project Summary Obesity affects more than 1.4 billion adults worldwide and is a significant risk factor for chronic diseases such as hypertension, diabetes, and cardiovascular diseases. Present non-operative treatment options of obesity are woefully inadequate. Bariatric surgery is effective but invasive, costly, and associated with significant morbidity. Intragastric balloons (IGB) have been demonstrated to be effective in enabling temporary weight loss (~25-30% of excess body weight), allowing the improvement of metabolic parameters. However, IGB is a passive mechanical construct that cannot be monitored or controlled upon insertion and require endoscopy delivery. These fundamental attributes limit the reach of IGB to very selected patients as a temporary treatment or as a bridging intervention to bariatric surgery despite its effectiveness. The proposed research will overcome the fundamental limitations of IGB by creating an ingestible gastric-resident electronic-enhanced metamaterial architecture (iGEM). In stark contrast to the current strategies, iGEM can transform obesity treatment with a digital-based personalized and dynamic treatment strategy. iGEM allows the dynamic tuning of gastric restrictive effect, which can be optimized based on safety consideration, patient’s treatment goals, and the quality of life desired. For example, feedback-based control of the device distension can prevent excessive pressure point or over-inflation that may lead to ulcer formation; or to avoid intestinal obstruction due to premature disintegration. The ability to adjust gastric restrictive pressure can enhance treatment effectiveness to account for gastric accommodation. The ability to acquire sensing data can help elucidate the complex relationship between the restrictive effect of intragastric devices and treatment effectiveness. This research leverages Kong’s expertise in creating entirely 3D printable electronics and ingestible electronics, (2) Wang’s (Ph.D.) expertise in meta- materials design, and (3) Fang’s (M.D.) extensive clinical and clinical research experience in IGB usage and intragastric devices. Specifically, we will (1) develop wireless resonant-enhanced 3D printable gastric pressure sensors with a hybrid core-shell printing methodology that allow the integration of pressure sensors on a wide range of intragastric systems; (2) develop wirelessly triggered transformable active metamaterials architecture that is capable of achieving wirelessly triggered reversible structural reconfiguration, allowing the oral ingestion of the device, dynamic control of expansion to tailor gastric restriction effect and the safe excretion of the device without risk of intestinal obstruction; (3) develop and evaluate iGEM longitudinal wireless pressure sensing and triggerable volume control capability that can sustain the complex and dynamic gastric environment for a prolonged period of time (30 days). Upon completion of the proposed research, the foundation established by this proposed work is also applicable to include a wide range of inductance/capacitance-based sensors (temperature, biochemical, bacterial), as well as various ingestible or implantable systems such as stents, enabling multivariate longitudinal sensing and unprecedented control.

项目摘要肥胖影响着全球超过14亿成年人，是慢性疾病的重要风险因素，如高血压、糖尿病和心血管疾病。目前肥胖症的非手术治疗选择有严重不足。减肥手术是有效的，但侵入性，昂贵，并与显着的发病率。胃内球囊（IGB）已被证明可有效实现暂时性体重减轻（约25-30%）过量体重），允许代谢参数的改善。然而，IGB是被动的插入时无法监测或控制的机械结构，需要内窥镜输送。这些基本属性限制了IGB作为临时治疗或作为治疗药物的范围，尽管减肥手术很有效，但它是一种过渡性干预。这项研究将克服通过创建可摄入的胃驻留电子增强超材料来实现IGB的基本限制 iGEM架构。与目前的策略形成鲜明对比的是，iGEM可以通过基于数字化的个性化和动态治疗策略。iGEM允许动态调整胃限制性效果，可根据安全性考虑、患者治疗目标和生活质量进行优化需要的话例如，对装置扩张的基于反馈的控制可以防止过度的压力点或收缩。过度充气可能导致溃疡形成;或避免由于过早崩解而导致肠梗阻。调节胃限制性压力的能力可以提高治疗效果，以解释胃粘膜的损伤。住宿.获取感测数据的能力可以帮助阐明胃内装置的限制作用和治疗有效性。这项研究利用了孔的专业知识在创造完全3D打印的电子产品和可摄取的电子产品，（2）王的（博士）在Meta- 材料设计，以及（3）方（医学博士）在IGB使用方面具有丰富的临床和临床研究经验，胃内装置。具体来说，我们将（1）开发无线共振增强3D打印胃压具有混合核-壳印刷方法的传感器，该方法允许在宽范围内集成压力传感器。一系列胃内系统;（2）开发无线触发的可转换有源超材料架构能够实现无线触发的可逆结构重构，动态控制扩张以适应胃限制效果和装置的安全排泄无肠梗阻风险;（3）开发和评估iGEM纵向无线压力传感，可持续的容量控制能力，可维持复杂和动态的胃环境，长期（30天）。在拟议的研究完成后，所提出的这项工作也适用于包括各种基于电感/电容的传感器（温度、生物化学、细菌），以及各种可摄取或可植入系统，例如支架，从而实现多变量纵向感测和前所未有的控制。