Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure
机器学习方法评估孕产妇压力暴露导致产前和新生儿缺铁性贫血的风险
基本信息
- 批准号:10688126
- 负责人:
- 金额:$ 12.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnemiaAnimalsAwardBehavioralBioinformaticsBiologicalBiometryBirthBlood VolumeBlood specimenC-reactive proteinChild DevelopmentChronicChronic stressDNA MethylationDataData SetDevelopmentDiagnosisDiseaseEndowmentExposure toFerritinFundingGenerationsGoalsHealthHematocrit procedureHemoglobinHydrocortisoneHypothalamic structureInfantInfant HealthInflammationInflammatoryIntakeInterleukin-6InterventionIronIron deficiency anemiaK-Series Research Career ProgramsLifeLow incomeMachine LearningMaternal HealthMaternal and Child HealthMeasuresMediatingMedical RecordsMental HealthMicroRNAsMinority WomenMothersNeonatalNeurosecretory SystemsOralOutcomePathway interactionsPatient Self-ReportPhasePhenotypePituitary GlandPlacentaPlayPopulationPregnancyPregnant WomenProcessPsychological StressPsychophysiologyPsychosocial StressRaceRegulationResearchRiskRisk AssessmentRisk FactorsRoleShapesSignal TransductionStatistical MethodsStressStressful EventSupplementationTechniquesTestingThird Pregnancy TrimesterTimeTrainingUmbilical Cord BloodVitaminsWomanWorkabsorptionadverse pregnancy outcomebiological adaptation to stresscohortcytokineearly life stressethnic minorityexperiencefetalfetal programminghepcidinhigh riskinfancyinflammatory markerinsightiron absorptioniron supplementmRNA Expressionmachine learning methodmaternal riskmaternal stressmean corpuscular volume observedmodifiable riskmultidimensional dataneonateneurodevelopmentnutrient metabolismoffspringphysical conditioningpre-clinicalpregnantprenatalprenatal stressprospectiveracial minorityrecruitskillssocioeconomicssupervised learningsystemic inflammatory responsetranslational research program
项目摘要
PROJECT SUMMARY
This K99 application aims to determine biological and behavioral pathways by which maternal psychosocial
stress in pregnancy impacts risk for maternal and infant iron deficiency anemia (IDA). IDA is one of the most
common causes of anemia worldwide, and around 20% of women in the US experience a stressful life event
throughout their pregnancy. Due to the increased iron demands of pregnancy, pregnancy itself poses a
significant risk of IDA, especially for low-income and racially- and ethnically-minoritized women. IDA increases
the risk of adverse pregnancy outcomes and can negatively impact the iron status of the neonate that may
cause irreversible harm to neurodevelopment. There is growing concern that oral vitamin supplementation
might not be enough to counteract the risks of IDA in the context of systemic inflammation, including
inflammation produced by chronic psychosocial stress and subsequent neuroendocrine dysregulation.
Maternal psychosocial stress has been associated with infant iron status previously, but the potential biological
mechanisms are not yet characterized despite the
项目摘要
这个K99应用程序的目的是确定生物和行为途径,产妇的心理社会
怀孕期间的压力会影响母亲和婴儿缺铁性贫血(IDA)的风险。IDA是世界上
全球范围内贫血的常见原因,美国约20%的女性经历过压力大的生活事件
整个怀孕期间。由于怀孕对铁的需求增加,怀孕本身就构成了
患IDA的风险很大,特别是对低收入和种族和民族少数的妇女。开发协会增加
不良妊娠结局的风险,并可能对新生儿的铁状况产生负面影响,
对神经发育造成不可逆转的伤害。人们越来越担心口服维生素补充剂
可能不足以抵消全身炎症背景下IDA的风险,包括
由慢性心理社会压力和随后的神经内分泌失调引起的炎症。
母亲的心理社会压力与婴儿铁的状况有关,但潜在的生物学
机制尚未表征,尽管
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes.
- DOI:10.3390/nu15173798
- 发表时间:2023-08-30
- 期刊:
- 影响因子:5.9
- 作者:Reid, Brie M.;Georgieff, Michael K.
- 通讯作者:Georgieff, Michael K.
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{{ truncateString('Brie M Reid', 18)}}的其他基金
Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure
机器学习方法评估孕产妇压力暴露导致产前和新生儿缺铁性贫血的风险
- 批准号:
10505909 - 财政年份:2022
- 资助金额:
$ 12.68万 - 项目类别:
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