Concordance with Dietary Approaches to Stop Hypertension (DASH) diet score and health outcomes among South Asians in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

项目概要/摘要 南亚人是美国增长最快的种族群体。尽管他们越来越多 虽然人口存在，但南亚人仍然没有得到充分的研究，并且经常与其他种族的人错误地聚集在一起。 分组。动脉粥样硬化性心血管疾病（ASCVD）在南亚裔美国人中高度流行， 然而，在这一人群中，关于导致纵向病程的特定风险因素的数据仍然有限。 ASCVD的发病率，并可在ASCVD的预防、早期干预和治疗中进行修改。饮食是一 建立ASCVD风险的预防模式，采用饮食方法阻止高血压（DASH） 饮食模式是国家心脏、肺和血液研究所（NHLBI）推荐的治疗饮食。 NHLBI在其研究重点中确定了八个目标，包括调查 说明不同人群的健康差异（目标3）和治疗策略的优化 预防、治疗和治愈疾病（目标5）。拟议研究的主要目标是解决这些问题 目的通过分析必要的数据，以了解如何与DASH饮食模式的一致性， 影响南亚裔美国人的ASCVD风险。这一目标将通过利用 生活在美国的南亚人中动脉粥样硬化的中介者（R 01 HL 093009），一项正在进行的纵向队列研究 对生活在美国的南亚成年人进行的一项研究：研究DASH饮食一致性与 已确定的ASCVD行为风险因素（吸烟、缺乏身体活动、饮酒）（目标1）; 确定DASH饮食一致性与中枢性肥胖指标之间的关联，基于 计算机断层扫描成像和人体测量（目标2）;并确定相关性 DASH饮食一致性与ASCVD临床危险因素（血压和新冠状动脉病变）之间的关系 动脉钙化评分）（Aim 3）。这项拟议中的研究将在纽约大学进行， 提供访问纽约大学图书馆，与广泛的计算机化目录，提供数字访问最开放的， 堆栈产品;数据服务，提供对专业软件包的访问、培训和支持， 统计分析;以及支持提案制定和促进研究的强大研究基础设施 纽约大学师生之间的互动。整个奖学金的培训目标包括（1） 发展和完善数据协调、管理和二级数据分析方面的技能;（2） 将根据食物频率问卷改编的文化相关DASH饮食模式评分操作化， 每月接受联合申办方的培训;（3）了解ASCVD的近端和远端风险因素 南亚人;（4）提高研究沟通技能，特别是提高认识， 以及在健康研究中纳入代表性不足的亚人群，促进科学的多样性。 与申办者、共同申办者、专家顾问和合作者的指导和监督将在 在整个研究金发放期间，定期提供培训，以加强各方面的培训。

PROJECT SUMMARY/ABSTRACT South Asians are the fastest growing ethnic population group in the United States (US). Despite their increasing population presence, South Asians remain understudied and are often mis-aggregated with other ethnic subgroups. Atherosclerotic cardiovascular disease (ASCVD) is highly prevalent among South Asian Americans, yet there remains limited data on specific risk factors in this population that contribute to the longitudinal course of ASCVD and that could be modified in the prevention, early intervention, and treatment of ASCVD. Diet is an established prevention modality for ASCVD risk, with the Dietary Approaches to Stop Hypertension (DASH) dietary pattern being the recommended therapeutic diet by the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI has identified eight objectives within their Research Priorities, including the investigation of factors that account for differences in health among populations (Objective 3) and optimization of therapeutic strategies to prevent, treat, and cure diseases (Objective 5). The primary goal of the proposed research is to address these objectives by analyzing data necessary to understand how concordance with the DASH dietary pattern influences ASCVD risk among South Asian Americans. This goal will be achieved by leveraging data from the Mediators of Atherosclerosis in South Asians Living in America (R01HL093009), an ongoing longitudinal cohort study of South Asian adults living in the US to: examine how DASH diet concordance is related to established ASCVD behavioral risk factors (smoking, physical inactivity, alcohol intake) (Aim 1); determine associations between DASH diet concordance and indicators of central adiposity, based on both computed tomography imaging and anthropometric measurements (Aim 2); and determine associations between DASH diet concordance and ASCVD clinical risk factors (blood pressure and the novel coronary artery calcium score) (Aim 3). The proposed research will take place at New York University (NYU), which provides access to NYU Libraries, with extensive computerized catalogs that provide digital access to most open- stack offerings; Data Services, which offer access, training, and support for specialty software packages for statistical analysis; and a robust research infrastructure that supports proposal development and fosters research engagement among NYU faculty and students. Training goals throughout the fellowship award include (1) developing and refining skills in data harmonization, management, and secondary data analysis; (2) operationalizing culturally relevant DASH dietary pattern scores adapted from food frequency questionnaires, with monthly training from the Co-Sponsor; (3) understanding the proximal and distal risk factors of ASCVD among South Asians; and (4) advancing research communication skills that specifically enhance the recognition and inclusion of underrepresented subpopulations in health research, contributing to diversity in science. Mentorship and supervision with Sponsor, Co-Sponsors, expert consultants and collaborator will occur on a regular basis throughout the fellowship award to augment all aspects of training.