Concordance with Dietary Approaches to Stop Hypertension (DASH) diet score and health outcomes among South Asians in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

项目摘要/摘要 南亚人是美国人口增长最快的种族群体。尽管他们的数量不断增加 由于人口的存在，南亚人仍然没有得到充分的研究，经常与其他民族混为一谈 子组。动脉粥样硬化性心血管疾病(ASCVD)在南亚裔美国人中高度流行， 然而，关于该人群中导致纵向病程的特定风险因素的数据仍然有限。 可用于ASCVD的预防、早期干预和治疗。节食是一种 建立了ASCVD风险的预防模式，以及停止高血压的饮食方法(DASH) 饮食模式是国家心肺血液研究所(NHLBI)推荐的治疗性饮食。 NHLBI在其研究重点中确定了八个目标，包括调查因素 这解释了不同人群之间的健康差异(目标3)和治疗策略的优化 预防、治疗和治愈疾病(目标5)。拟议研究的主要目标是解决这些问题 目标通过分析必要的数据来了解如何与DASH饮食模式相一致 影响南亚裔美国人患ASCVD的风险。这一目标将通过利用 居住在美国的南亚人动脉粥样硬化的介体(R01HL093009)，一项正在进行的纵向队列研究 对居住在美国的南亚成年人的研究：检查短跑饮食一致性如何与 已确定的ASCVD行为危险因素(吸烟、缺乏运动、饮酒)(目标1)； 确定DASH饮食一致性与中心性肥胖指标之间的关联 计算机断层扫描成像和人体测量(目标2)；并确定关联 DASH饮食一致性与ASCVD临床危险因素(血压和新冠脉病变)之间的关系 动脉钙化评分)(目标3)。这项拟议的研究将在纽约大学(NYU)进行，该校 提供对纽约大学图书馆的访问，具有广泛的计算机化目录，提供对大多数开放的- 堆栈产品；数据服务，提供对以下专业软件包的访问、培训和支持 统计分析；以及支持提案制定和促进研究的强大研究基础设施 纽约大学教职员工和学生之间的互动。整个奖学金奖项的培训目标包括(1) 发展和完善数据协调、管理和二次数据分析方面的技能；(2) 将根据食物频率问卷改编的具有文化相关性的DASH饮食模式得分付诸实施， 共同赞助者每月培训；(3)了解ASCVD的近端和远端危险因素 在南亚人中；和(4)提高研究交流技能，特别是提高认知度 以及将代表性不足的亚群纳入卫生研究，促进科学的多样性。 与赞助商、联合赞助商、专家顾问和合作者的指导和监督将在 在整个奖学金颁发过程中定期进行，以加强各方面的培训。

PROJECT SUMMARY/ABSTRACT South Asians are the fastest growing ethnic population group in the United States (US). Despite their increasing population presence, South Asians remain understudied and are often mis-aggregated with other ethnic subgroups. Atherosclerotic cardiovascular disease (ASCVD) is highly prevalent among South Asian Americans, yet there remains limited data on specific risk factors in this population that contribute to the longitudinal course of ASCVD and that could be modified in the prevention, early intervention, and treatment of ASCVD. Diet is an established prevention modality for ASCVD risk, with the Dietary Approaches to Stop Hypertension (DASH) dietary pattern being the recommended therapeutic diet by the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI has identified eight objectives within their Research Priorities, including the investigation of factors that account for differences in health among populations (Objective 3) and optimization of therapeutic strategies to prevent, treat, and cure diseases (Objective 5). The primary goal of the proposed research is to address these objectives by analyzing data necessary to understand how concordance with the DASH dietary pattern influences ASCVD risk among South Asian Americans. This goal will be achieved by leveraging data from the Mediators of Atherosclerosis in South Asians Living in America (R01HL093009), an ongoing longitudinal cohort study of South Asian adults living in the US to: examine how DASH diet concordance is related to established ASCVD behavioral risk factors (smoking, physical inactivity, alcohol intake) (Aim 1); determine associations between DASH diet concordance and indicators of central adiposity, based on both computed tomography imaging and anthropometric measurements (Aim 2); and determine associations between DASH diet concordance and ASCVD clinical risk factors (blood pressure and the novel coronary artery calcium score) (Aim 3). The proposed research will take place at New York University (NYU), which provides access to NYU Libraries, with extensive computerized catalogs that provide digital access to most open- stack offerings; Data Services, which offer access, training, and support for specialty software packages for statistical analysis; and a robust research infrastructure that supports proposal development and fosters research engagement among NYU faculty and students. Training goals throughout the fellowship award include (1) developing and refining skills in data harmonization, management, and secondary data analysis; (2) operationalizing culturally relevant DASH dietary pattern scores adapted from food frequency questionnaires, with monthly training from the Co-Sponsor; (3) understanding the proximal and distal risk factors of ASCVD among South Asians; and (4) advancing research communication skills that specifically enhance the recognition and inclusion of underrepresented subpopulations in health research, contributing to diversity in science. Mentorship and supervision with Sponsor, Co-Sponsors, expert consultants and collaborator will occur on a regular basis throughout the fellowship award to augment all aspects of training.