Vascular and Behavioral Determinants of Superior Memory Performance from Continuous Monitoring of Everyday Activities
通过持续监测日常活动来确定卓越记忆表现的血管和行为决定因素
基本信息
- 批准号:10687273
- 负责人:
- 金额:$ 15.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAcousticsAddressAdultAffectAgeAgingAutonomic nervous systemBathingBehaviorBehavioralBehavioral MechanismsBiologicalBlood PressureBlood VesselsClinic ActivityClinicalClinical assessmentsCognitiveCognitive agingComplexDataData ReportingDementiaEconomicsElderlyElectrocardiogramEnrollmentEntropyEquilibriumExerciseFosteringFrequenciesFutureGeroscienceGoalsHeart RateHomeHourImageImmuneImpaired cognitionLinkLiteratureMeasurementMeasuresMediatorMemoryMonitorNeighborhoodsNervous System PhysiologyOxygenParticipantPathway interactionsPatient Self-ReportPatternPerformancePeripheralPersonsPhenotypePhysical activityPhysiologicalProcessRaceReactionResearchResourcesRespirationSeriesSignal TransductionSkinSleepSleep FragmentationsSleep StagesSocial FunctioningSystemTestingTimeWorkage relatedage related cognitive changebody systemcohortcomparison controlflexibilityindexingneuralnovelnovel strategiespoor sleeppreservationremote monitoringresilienceresponsesedentarysensorsexsleep patternsleep qualitysocialsocial engagementsocioeconomicsstandardize measureverbalwearable devicewireless
项目摘要
ABSTRACT (Project 1)
Project 1 will leverage the SuperAging Consortium to test the supposition that SuperAgers have relatively
preserved physiologic and behavioral complexity, compared to Controls, in the domains of physical activity,
autonomic responsivity (e.g., blood pressure, heart rate), sleep, and social engagement. The number of people
80 years and older is expected to triple to ~ 426 million by the year 2050 making successful aging an essential
social and economic priority. Typical aging is associated with challenges responding dynamically to heightened
system demands (internal or external). This loss of responsiveness, and/or ability to stabilize the system, (framed
theoretically as a ‘loss’ of physiologic and behavioral ‘complexity’) accounts for a number of age-related declines
in neural connectivity, balance control, memory, among others. However, SuperAgers appear immune to some
age-related cognitive changes, and thus represent an ‘ideal’ aging target. Whilst SuperAgers self-report
increased physical activity and social engagement compared to their Controls, little is known about the actual
physiologic and behavioral differences that distinguish SuperAgers. This is a critical missing link in understanding
processes that underlie potential pathways to successful aging. The SuperAging Consortium offers a unique
opportunity to reveal this missing link, and importantly, to do so in a diverse cohort. Understanding how loss of
complexity manifests in everyday activities requires sensitive, multiple time-scale, measurements capable of
capturing dynamic and complex behaviors in a way not afforded by point-in-time and clinical assessments. We
will collect mechanoacoustic sensor recordings, during every day activities, over 24-hour time periods for two
weeks in both SuperAgers and their Controls co-enrolled with the Clinical/Imaging Core. Using multiscale entropy
approaches we will generate a ‘complexity’ score that captures the quality, quantity, range, and consistency of
physical activity, autonomic nervous system function, sleep, and social engagement behaviors within, and
across, days. In Aim 1, we will determine whether loss of complexity in physical activity and autonomic nervous
system (ANS) activity differentiates SuperAgers from Controls. In Aim 2, we will determine whether loss of
complexity in sleep quality and ANS activity during sleep differentiates SuperAgers from Controls. In Aim 3, we
will determine whether complexity in social engagement differentiates SuperAgers from Controls. We predict
that compared to their Controls, SuperAgers will demonstrate higher physical activity complexity and higher
autonomic function complexity reflecting greater overall levels and quality of physical activity; lower (i.e., better)
sleep complexity scores reflecting lower variability in sleep patterns; and higher social engagement complexity
scores suggesting they are more consistently engaged in verbal activities compared to typical agers. Project 1
will expand the SuperAging phenotype, reveal whether SuperAgers are immune to loss of physiologic and
behavioral complexity, and will accelerate geroscience discoveries by fostering future high impact studies that
can address novel hypotheses linking biological, physiologic, and behavioral mechanism of aging.
摘要(项目一)
项目成果
期刊论文数量(0)
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Angela Roberts其他文献
Angela Roberts的其他文献
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{{ truncateString('Angela Roberts', 18)}}的其他基金
Vascular and Behavioral Determinants of Superior Memory Performance from Continuous Monitoring of Everyday Activities
通过持续监测日常活动来确定卓越记忆表现的血管和行为决定因素
- 批准号:
10276527 - 财政年份:2021
- 资助金额:
$ 15.87万 - 项目类别:
Phase 2 Development of a Spoken Language Biomarker of Cognitive Impairment in Parkinson's Disease
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9903270 - 财政年份:2019
- 资助金额:
$ 15.87万 - 项目类别:
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