Case Western Researve Clinical and Translational Science Institute (UL1)

翻译和临床研究是生物医学研究的至高无上的荣耀，但 这项研究没有得到应有的重视。在案例中西部储备大学/克利夫兰 临床CTSA(CTSA)我们将协调凯斯韦斯特临床研究相关的现有资源 储备大学及其三家附属医院，克利夫兰诊所，MetroHealth医疗中心和 大学医院案例医疗中心，包括三个现有的GGRC设施，一个成功的 多学科机构K12计划，实质性的技术和统计核心设施， 目前存在于筒仓和我们著名的实践型研究网络中。此外，我们还将创建新的 资源，包括社区伙伴关系资源、新的协调生物信息学基础设施、 在临床研究方面的新的医学博士项目，以及在生物伦理和监管支持方面的协调资源。 临床研究的学术中心，由CTSA PI和CTSA PI指导的临床调查中心 凯斯医学院临时院长将提供必要的职业发展支持 临床调查员。当它完全运作时，CTSA将向研究参与者提供以下资源 跨越对需要学术医学资源的技术密集型研究的支持范围 中心，地方实践，克利夫兰社区本身。社区，包括组织和 个人将参与关于以患者为基础的研究的对话。这些参与者资源将是 在技术核心、方法开发和生物医学信息学基础设施的支持下。 渗透到整个企业的是一个由CTSA Co-Pi指导的教育项目，它充分利用了 不仅是我们的院校教育实力，而且是CTSA临床研究资源的优势。 CTSA资源将通过临床研究礼宾在线或面对面轻松访问， 这将确保对统计和设计专家、伦理学家和监管机构的提案提出预期的意见 专家，以及项目所需的任何其他专业知识。精简业务和协调 在CTSA伙伴之间强有力的合作的背景和记录的背景下，资源将 使克利夫兰市的稀缺资源得到有效利用，并最大限度地支持临床研究， 这最终将使我们的公民和所有美国人的健康受益。

Translational and clinical research are the crowning glories of biomedical research, but the infrastructure for this research has not received appropriate attention. In the CaseWestern ReserveUniversity/Cleveland Clinic CTSA (the CTSA) we will coordinate existing resources relevant to clinical research at Case Western Reserve University and three of its hospital affiliates, the Cleveland Clinic, MetroHealth Medical Center, and University Hospitals Case Medical Center, including three existing GGRCfacilities, a successful multidisciplinary institutional K12 program, substantial technological and statistical core facilities that currently exist in silos, and our famous practice-based research networks. In addition, we will create new resources, including community partnership resources, a new coordinated bioinformatics infrastructure, a new M.D-Ph.D. program in clinical research, and coordinated resources in bioethics and regulatory support. An academic home for clinical research, the Center for Clinical Investigation, directed by the CTSA PI and Interim Dean of the Case School of Medicine, will provide the career development support necessaryfor clinical investigators. When it is fully operational, the CTSAwill offer research participant resources that span the range of support for technology-intensive studies that require the resource of the Academic Medical Centers, to local practices, to the Cleveland community itself. The community, both organizations and individuals, will be engaged in a dialogue about patient-based research. These participant resources will be supported by technologic cores, methodologic development, and an infrastructure of biomedical informatics. Permeating the entire enterprise is an educational program, directed by the CTSA Co-Pi, that takes full advantage of not only our institutional educational prowess, but also the CTSA clinical researchresources. CTSA resources will be easily accessed either online or in person through a Clinical Research Concierge, which will assure prospective input into proposals by statistics and design experts, ethicists:and regulatory experts, and any other expertise that the project requires. Streamlining of operations and coordinationof resources, set against a backdrop and track record of strong cooperation among the CTSA partners,will lead to efficient use of scarce resources and maximal support of clinical research in the city ofCleveland, which ultimately will benefit our citizens and the health of all Americans.