Understanding practical alcohol measures in primary care to prepare for measurement-based care: Scaled EHR measures of alcohol use and DSM-5 AUD symptoms

了解初级保健中的实用酒精测量方法，为基于测量的护理做好准备：酒精使用和 DSM-5 AUD 症状的按比例 EHR 测量

• 批准号: 10688183
• 负责人: Kevin A Hallgren
• 金额: $ 37.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688183
• 关键词: Accounting; Address; Adult; Affect; Age; Alcohol abuse; Alcohol consumption; Alcohols; Appointment; Awareness; Blood Pressure; Caring; Clinical; Cross-Sectional Studies; DSM-V; Data; Data Set; Development; Diagnosis; Electronic Health Record; Ethnic Origin; Ethnic Population; Evaluation; Foundations; Frequencies; Future; Health; Health Services; Health system; Healthcare Systems; Hospitalization; Measurement; Measures; Medical; Methodology; Monitor; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Patient Outcomes Assessments; Patients; Performance; Persons; Phase; Physiological; Positioning Attribute; Prevalence; Primary Care; Provider; Psychometrics; Public Health; Race; Readiness; Reporting; Research; Research Personnel; Risk; Sample Size; Sampling; Severities; Standardization; Subgroup; Symptoms; Testing; Time; Washington; Woman; Work; alcohol measurement; alcohol misuse; alcohol screening; alcohol use disorder; behavioral health; care systems; clinical care; clinical practice; depressive symptoms; disability; drinking; epidemiology study; implementation study; implementation trial; improved; longitudinal analysis; male; mortality; novel; pragmatic study; pragmatic trial; primary care patient; primary care setting; racial population; research study; response; routine care; routine screening; sex; standardize measure; young adult

Project Summary. Primary care (PC) is well-positioned to detect and address unhealthy drinking and alcohol use disorder (AUD), yet most PC settings have notable gaps in providing alcohol-related care. One way to improve alcohol-related care is to use standardized measurements to screen for unhealthy alcohol use and to assess AUD symptoms, which informs clinical care by detecting unhealthy drinking, assessing AUD severity, informing decisions about AUD treatment intensity, and monitoring clinical outcomes over time. Researchers and national agencies are increasingly calling for the use of standardized measures of unhealthy drinking and AUD symptoms in routine PC settings; however, surprisingly little is known about how such measures perform or what they indicate about health risks when they are used in the context of routine PC—i.e., administered in routine appointments and documented in electronic health records (EHRs). We propose to leverage a large and novel EHR dataset from Kaiser Permanente Washington, a large integrated regional health system. The dataset will include: the AUDIT-C alcohol screening measure, completed as part of an annual screen by >250,000 patients (89% of adults who attend PC appointments); a novel patient-reported AUD symptom checklist that is based on the 11 DSM-5 AUD criteria (“DSM-5 checklist”), completed by over 4,000 patients (>70% of those with AUDIT-C scores ≥ 7); and diverse health outcome measures available from EHR, administrative, and claims data. The 2-year developmental R21 phase includes psychometric analyses that evaluate the DSM-5 checklist as a scaled measure of AUD severity and the consistency of its performance across demographically diverse subgroups; to our awareness, this is the first study to evaluate any standardized patient-reported AUD symptom measure integrated into routine PC. Cross-sectional analyses will examine associations between the AUDIT-C, DSM-5 checklist, and important health outcome measures known to be associated with drinking, including systolic blood pressure, patient-reported depression symptoms, hospitalizations for alcohol-attributable conditions, all-cause hospitalizations, and all-cause mortality. The R21 will also achieve milestones demonstrating readiness for the R33 phase. During the 3-year R33 phase, longitudinal analyses will test whether the AUDIT-C and DSM-5 checklist are associated with subsequent health outcomes and whether within-person changes in AUDIT-C scores over time are associated with changes in health outcomes. To our awareness, this work will be the first to evaluate a patient-reported AUD symptom checklist in any routine PC setting and the first to evaluate the AUDIT-C in any non-veteran routine PC setting. This research will improve clinical care by helping providers and patients understand the information provided by these scaled patient-reported measures and their associations with important adverse health outcomes. The work will also provide a foundation for future studies that use patient-reported EHR- based measures in pragmatic studies, implementation trials, and quality improvement initiatives.

项目摘要。初级保健（PC）能够很好地检测和解决不健康的饮酒和酒精问题 使用障碍（AUD），但大多数PC设置在提供酒精相关的护理有显着的差距。的一种方法 改善酒精相关护理是使用标准化的测量来筛查不健康的酒精使用， 评估AUD症状，通过检测不健康的饮酒，评估AUD严重程度， 为AUD治疗强度的决策提供信息，并随时间推移监测临床结局。研究人员 国家机构越来越多地呼吁使用不健康饮酒的标准化措施， 常规PC设置中的AUD症状;然而，令人惊讶的是，人们对这些措施的表现知之甚少 或者当它们在常规PC的背景下使用时，它们表明了什么健康风险，即，施用 常规预约并记录在电子健康记录（EHR）中。我们建议利用一个大的 和来自Kaiser Permanente华盛顿的新型EHR数据集，Kaiser Permanente是一个大型综合区域卫生系统。的 数据集将包括：AUDIT-C酒精筛查措施，作为年度筛查的一部分，由 > 250，000例患者（89%的成年人参加PC预约）;一种新的患者报告的AUD症状 基于11项DSM-5 AUD标准的检查表（“DSM-5检查表”），由4，000多名患者完成 （>70%的AUDIT-C评分≥ 7）;以及EHR提供的多种健康结局指标， 行政和索赔数据。2年的发展R21阶段包括心理测量分析， 评估DSM-5检查表，作为AUD严重程度及其性能一致性的衡量标准 在人口统计学上不同的亚组中;据我们所知，这是第一项评估任何 将标准化患者报告的AUD症状测量纳入常规PC。横截面分析将 检查AUDIT-C、DSM-5检查表和已知的重要健康结果指标之间的关联 与饮酒有关，包括收缩压，患者报告的抑郁症状， 因酒精引起的疾病住院、全因住院和全因死亡。R21 还将实现里程碑，证明R33阶段的准备就绪。在3年的R33阶段， 纵向分析将测试AUDIT-C和DSM-5检查表是否与随后的 健康结果以及AUDIT-C评分随时间的变化是否与 健康结果的变化。据我们所知，这项工作将是第一个评估患者报告的AUD 症状检查表在任何常规PC设置和第一个评估AUDIT-C在任何非退伍军人常规 PC设置。这项研究将通过帮助提供者和患者了解 这些按比例缩放的患者报告指标提供的信息及其与重要不良反应的相关性 健康成果。这项工作还将为未来使用患者报告的EHR的研究提供基础， 在务实的研究，实施试验和质量改进措施的基础上。