CTRC Core

CTRC核心

• 批准号: 10688043
• 负责人: Charles Bernick
• 金额: $ 80.76万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688043
• 关键词: Acceleration; Address; Affect; Age; Aliquot; Alzheimer' s Disease; Biochemical; Biological; Biological Assay; Biological Markers; Biomedical Research; Brain imaging; COVID-19; Centers of Research Excellence; Clinic; Clinical; Clinical Research; Clinical assessments; Cognitive; Collaborations; Collection; Communities; Community Outreach; Complex; Data; Databases; Dedications; Diagnostic; Disease; Education; Education and Outreach; Elderly; Elements; Enrollment; Ensure; Ethnic Origin; Evaluation; Funding; Genetic; Goals; Image; Impaired cognition; Individual; Inflammation; Infrastructure; Instruction; Molecular Profiling; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychology; Nevada; Parkinson Disease; Participant; Phase; Phenotype; Population; Procedures; Productivity; Psychometrics; Race; Recurrence; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Review Committee; Role; Sampling; Science; Services; Source; Specimen; Standardization; Translational Research; Universities; Vision; biobank; blood-based biomarker; brain health; clinical diagnosis; cognitive testing; cohort; comparison group; equity, diversity, and inclusion; experience; follow-up; high risk population; human old age (65+); innovation; longitudinal analysis; meetings; mild cognitive impairment; minority communities; minority engagement; multimodality; neuroimaging; neuroinflammation; neurophysiology; outreach; outreach program; pandemic disease; participant safety; patient population; performance tests; programs; recruit; socioeconomic diversity; southern nevada; success; translational neuroscience; web site

SUMMARY/ABSTRACT Clinical and Translational Research Core (CTRC) The Clinical and Translational Research Core (CTRC) provides the infrastructure for neurodegenerative disease (NDD) clinical research within the Center for Neurodegenerative and Translational Neuroscience (CNTN). In Phase 1, the Core recruited, characterized, and retained a clinical cohort consisting of more than 190 “deeply phenoyped” research participants across five diagnostic groups: mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), Parkinson’s disease (PD) with no cognitive impairment (PD-NC), PD with mild cognitive impairment (PD-MCI), and cognitively normal controls (CNC). Data from this cohort directly supported the research goals of 5 projects in Phase 1, as well several other collaborations. In Phase 2, the core will extend the study up to ten years. As in Phase 1, the CTRC will provide each project leader with operational and regulatory support, project management, and research instruction that will help advance them toward the goal of independent funding. A notable enhancement of the Clinical Core in Phase 2 includes a focus on the role of neuroinflammation in NDD. The CTRC’s multimodal approach to neuroinflammation (including neuroimaging, blood-based biomarkers, genetics, and clinical assessments) represents one of the first comprehensive databases in the field of NDD. In addition to sustaining the clinical core, the CTRC will focus on increasing participation rates of traditionally underrepresented patient populations. Participation will be facilitated through expansion of our education and outreach program. This program, which was implemented in Phase 1, is guided by input from a Community Advisory Board (CAB) and includes an innovative education and outreach website (Healthybrains.org). Finally, the core will also establish the first biobank in Southern Nevada at the University of Nevada-Las Vegas (UNLV) under the direction of Dr. Jefferson Kinney. This new resource will store, analyze, and provide expertise in the evaluation of non-clinical and clinical biospecimens. In addition to supporting the currently proposed projects, a number of additional COBRE and non-COBRE collaborators will access this valuable resource. The CTRC has formative and summative assessments imbedded within in that will insure success in achieving its specific aims.

摘要/摘要 临床和翻译研究核心（CTRC） 临床和转化研究核心（CTRC）为神经退行性疾病提供了基础设施 （NDD）神经退行性和转化神经科学中心（CNTN）中的临床研究。在 第1阶段，核心招募，表征和保留了由190多个“深度”组成的临床队列 跨五个诊断组的研究参与者：轻度认知障碍（MCI），中期 阿尔茨海默氏病（AD），帕金森氏病（PD），没有认知障碍（PD-NC），PD，中部 认知障碍（PD-MCI）和认知正常对照（CNC）。该队列的数据直接支持 第1阶段的5个项目的研究目标以及其他几项合作。在第2阶段，核心将扩展 该研究长达十年。与第1阶段一样，CTRC将为每个项目负责人提供运营和 监管支持，项目管理和研究指导将有助于他们朝着目标迈进 独立资金。第2阶段临床核心的显着增强包括关注 NDD中的神经炎症。 CTRC的多模式神经炎症方法（包括神经影像学， 基于血液的生物标志物，遗传学和临床评估）代表了第一个综合的一种 NDD领域的数据库。除了维持临床核心外，CTRC还将专注于增加 传统代表性不足的患者人群的参与率。参与将通过 扩展我们的教育和外展计划。该程序在第1阶段实施，被指导 通过社区顾问委员会（CAB）的意见，包括创新的教育和外展网站 （Healthybrains.org）。最后，核心还将在内华达州南部建立第一家生物库 内华达州拉斯维加斯（UNLV）在杰斐逊·金尼博士的指导下。这个新资源将存储，分析， 并提供评估非临床和临床生物测量的专业知识。除了支持 目前提出的项目，许多其他毛绒和非近代合作者将访问此 有价值的资源。 CTRC具有嵌入其中的形成性和总结性评估，这将确保 成功实现其具体目标。