Molecular Virology/Epidemiology HIV Training in Kazakhstan (MoVE-Kaz)

从2010年到2020年，东欧和中亚新感染艾滋病毒的人数增加了43%， 而在哈萨克斯坦，艾滋病毒感染者(PLWH)的估计人数增加了133%， 表明传播感染的关键人群缺乏了解，也没有有效地与 减少危害服务，保证需要有效的培训和能力建设，以提高效率 监视系统。重建病毒传播网络的分子流行病学方法形成了一个 结束流行病计划(https://www.cdc.gov/endhiv/index.html).)的明确部分作为计划的一部分 NIDA资助的赠款，我们已经通过分子流行病学方法获得了关键信息 并提供了关于目前正在出现感染的高危社区的准确数据 建议他们优先进行干预。虽然我们的NIDA赠款在培训 几位年轻的哈萨克斯坦科学家在尖端分子流行病学工具方面，能力 这样的技能在哈萨克斯坦很少见。在这里，我们提出了一个D43培训计划，分子病毒学 哈萨克斯坦流行病学(MOVE-KAZ)，建设#年分子流行病学研究能力 哈萨克斯坦。我们的具体目标是：1.建设一支能力雄厚的哈萨克斯坦教师队伍 谁从事分子病毒学研究，我们将：a)与来自 耶鲁大学、纽约州立大学和比利时鲁汶大学 两个由6名哈萨克斯坦卫生专业人员和分子病毒学青年科学家组成的队列(12名 受训人员总数)，b)聘请当地和国际导师指导受训人员应用分子 调查公共卫生问题的流行病学工具，c)培训哈萨克斯坦卫生专业人员 以及分子病毒学和流行病学领域的科学家通过短期和长期的培训 在哈萨克斯坦境内，以及纽黑文和鲁汶。2.增强艾滋病病毒研究能力 分子流行病学在哈萨克斯坦，我们的Move-Kaz计划将培训哈萨克斯坦的年轻人 医生和科学家：a)分子病毒学和流行病学的基本和高级概念 通过两个为期3个月的证书课程，b)通过为期18个月的 研究感染传播和出现的分子病毒学研究证书课程， 耐药性和病毒变异-应用这些知识来改善艾滋病毒监测和患者 关怀，c)符合国际标准的研究的道德行为，以及d)制定 用于资助分子病毒学和流行病学研究的竞争性赠款。鉴于持续的 鉴于CA的艾滋病毒激增，我们相信培训拨款的主题和时机是令人信服的。带着我们的 经验丰富的国际公认的系统发育分析专家团队，我们相信 我们可以在哈萨克斯坦年轻科学家个人的能力建设方面取得实质性飞跃。

From 2010 to 2020, the number of new HIV infections in Eastern Europe and Central Asia increased by 43%, while in Kazakhstan, the estimated number of people living with HIV infection (PLWH) increased by 133%, an indication that the key populations transmitting the infections are poorly understood and not effectively linked to harm reduction services, warranting a need for effective training and capacity building for efficient surveillance. Molecular epidemiology approach to reconstruct viral transmission networks forms an explicit part of the Ending the Epidemic program (https://www.cdc.gov/endhiv/index.html). As part of a NIDA-funded grant, we have obtained key information through molecular epidemiology approaches and provided pin-point data regarding high-risk communities in which currently emerging infections suggest their prioritization for intervention. While our NIDA grant has been instrumental in training a handful of young Kazakhstani scientists in cutting-edge molecular epidemiology tools, capacity for such skills is scarce in Kazakhstan. Here, we propose a D43 training program, Molecular Virology Epidemiology in Kazakhstan (MoVE-Kaz), to build capacity for molecular epidemiology research in Kazakhstan. Our specific aims are: 1. To build a pool of well-capacitated Kazakhstani faculty who conduct molecular virology research, we will: a) collaborate with international mentors from Yale University, SUNY-Downstate, and Katholieke Universiteit Leuven in Belgium for the training of two cohorts of 6 Kazakhstani health professionals and young scientists in Molecular Virology (12 trainees total), b) engage local and international mentors to mentor the trainee in applying molecular epidemiology tools for investigating Public Health problems, c) train Kazakhstani health professionals and scientists in the field of molecular virology and epidemiology through short- and long-term training within Kazakhstan, and in New Haven and Leuven. 2. To enhance research capacity for HIV molecular epidemiology in Kazakhstan, our MoVE-Kaz program will train young Kazakhstani physicians and scientists: a) in basic and advanced concepts of molecular virology and epidemiology through two 3-month certificate courses, b) to develop hands-on research skills through an 18-month research certificate course molecular virology for studying transmission and emergence of infection, drug resistance, and viral variants – applying this knowledge to improve HIV surveillance and patient care, c) in ethical conduct of research that meets international standards, and d) in developing competitive grants to fund research in molecular virology and epidemiology. Given the continued surge of HIV in CA, we believe the topic and timing of the training grant is compelling. With our experienced and internationally recognized team of experts in phylogenetic analysis, we believe that we can make a substantial leap in capacity-building for young individual scientists in Kazakhstan.