Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
基本信息
- 批准号:10689205
- 负责人:
- 金额:$ 61.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAlgorithmsAnodesAreaBiomedical ResearchCherenkov RadiationClinicalComplementComputational algorithmDataData CollectionDetectionDevelopmentDiagnostic Neoplasm StagingDiscriminationDiseaseEventExcisionEyeFoundationsFutureGenerationsGeometryGlassGoalsHealthHospitalsImageImaging DeviceLeadLightLocationMachine LearningMeasuresMonte Carlo MethodNatureNoiseOpticsOutcomePatientsPerformancePhotonsPhysicsPositioning AttributePositronPositron-Emission TomographyPropertyRadiation Dose UnitRadioisotopesReaction TimeRefractive IndicesResolutionSamplingScanningSeriesSignal TransductionSystemTechniquesTechnologyThree-Dimensional ImageThree-Dimensional ImagingTimeTranslationsTubeVisionWorkbreast imagingclinical applicationclinical imagingclinical translationconvolutional neural networkdeep learningdesigndetection sensitivitydetectorflexibilityheart imaginghuman imagingimage reconstructionimaging platformimaging systemimprovedinnovationinstrumentationmachine learning algorithmnovelpersonalized carephotomultiplierportabilitypreservationprocess improvementprototyperadiotracerreal-time imagesreconstructionresponsescale upsignal processingsimulationtomographytooltreatment response
项目摘要
Project Summary/Abstract
A major advantage of coincidence detection of annihilation photons from positron-emitting radiotracers is the
availability of time-of-flight (TOF) information, and the ability to measure TOF differences to better localize the
positron emitter. Normally for positron emission tomography (PET), TOF information is used as a weighting
kernel during image reconstruction and results in an effective sensitivity gain that can be used to reduce radiation
dose, improve signal-to-noise ratio, or reduce scan duration. The magnitude of these benefits depend on the
TOF resolution, which is governed by the timing performance of the detectors. Current state of the art for PET
scanners is ~220 ps which corresponds to a localization of ~3.3 cm. A transformational change would occur,
however, if a TOF resolution of <30 ps could be achieved. This would localize events within 4.5 mm, allowing
images to be directly generated without a reconstruction algorithm at a spatial resolution that matches what is
achieved in clinical PET scanners today. We refer to this as direct positron emission imaging (PEI). With this
superb TOF resolution and reconstruction-free imaging, we enter a new regime where we expect major increases
in image signal-to-noise, both due to the additional TOF information, and the removal of noise amplification
inherent in reconstructing noisy data with noisy corrections from projection data. We propose to develop a first
proof-of-concept imaging system that uses ultra-fast detectors to directly produces cross-sectional images
without reconstruction and to quantify the performance of PEI both through simulations and experimentally.
Since direct PEI does not have the same sampling constraints for data collection as PET, it creates opportunities
for portable, and flexible imaging devices, with implications for patient-tailored or task-specific imaging
applications (i.e. cardiac or breast imaging), as well as open designs for general purpose applications.
To achieve the unprecedented TOF capabilities needed for direct PEI, we will exploit promptly emitted Cerenkov
radiation that is generated with <10 ps in certain materials, including scintillators, in response to a 511 keV
photon interaction. Our proposed novel detector design integrates a Cerenkov radiator directly into the entrance
window of an ultra-fast microchannel plate photomultiplier tube, which is the fastest photon detector currently
available with a response time of 25 ps. This approach eliminates all optical reflections between the point of light
generation and the photocathode, preserving the prompt timing nature of Cerenkov photons. We then combine
the integrated Cerenkov radiator detector with auxiliary photodetector read-out for robust coincidence detection,
and complement this with advanced signal processing algorithms we have pioneered using convolutional neural
networks to extract all possible timing information from the digitized detector waveforms and ultimately to perform
reconstruction-free imaging using only the digitized waveforms as input. In summary, we aim to prove that direct
PEI is possible, to characterize its properties and to provide the technological and algorithmic foundations for
eventual translation for human imaging.
项目概要/摘要
正电子发射放射性示踪剂湮灭光子的符合检测的一个主要优点是
飞行时间 (TOF) 信息的可用性,以及测量 TOF 差异以更好地定位的能力
正电子发射器。通常对于正电子发射断层扫描 (PET),TOF 信息用作加权
图像重建期间的内核并产生有效的灵敏度增益,可用于减少辐射
剂量、提高信噪比或缩短扫描时间。这些好处的大小取决于
TOF 分辨率,由探测器的定时性能决定。 PET 的最新技术水平
扫描仪的速度约为 220 ps,对应于 ~3.3 cm 的定位。将会发生翻天覆地的变化,
然而,如果可以实现 <30 ps 的 TOF 分辨率。这会将事件定位在 4.5 毫米以内,从而允许
无需重建算法即可直接生成图像,其空间分辨率与实际图像相匹配
如今,临床 PET 扫描仪已实现这一目标。我们将此称为直接正电子发射成像 (PEI)。有了这个
卓越的 TOF 分辨率和免重建成像,我们进入了一个新的领域,我们预计将大幅提高
在图像信噪比中,由于附加的 TOF 信息以及噪声放大的消除
通过投影数据的噪声校正来重建噪声数据是固有的。我们建议开发第一个
使用超快探测器直接生成横截面图像的概念验证成像系统
无需重建,并通过模拟和实验量化 PEI 的性能。
由于直接 PEI 没有与 PET 相同的数据收集采样限制,因此它创造了机会
用于便携式、灵活的成像设备,对患者定制或特定任务成像有影响
应用(即心脏或乳腺成像),以及通用应用的开放式设计。
为了实现直接 PEI 所需的前所未有的 TOF 能力,我们将利用快速发射的 Cerenkov
某些材料(包括闪烁体)响应 511 keV 产生的辐射 <10 ps
光子相互作用。我们提出的新颖探测器设计将切伦科夫散热器直接集成到入口中
超快微通道板光电倍增管的窗口,这是目前最快的光子探测器
响应时间为 25 ps。这种方法消除了光点之间的所有光学反射
生成器和光电阴极,保留了切伦科夫光子的即时计时性质。然后我们结合
集成的切伦科夫辐射探测器具有辅助光电探测器读出功能,可实现强大的重合检测,
并用我们率先使用卷积神经网络的先进信号处理算法来补充这一点
网络从数字化检测器波形中提取所有可能的定时信息,并最终执行
仅使用数字化波形作为输入的免重建成像。总之,我们的目标是证明直接
PEI 可以描述其属性并提供技术和算法基础
最终翻译为人类成像。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sun Il Kwon其他文献
The oil production performance analysis using discrete fracture network model with simulated annealing inverse method
- DOI:
10.1007/s12303-013-0034-y - 发表时间:
2013-07-05 - 期刊:
- 影响因子:1.500
- 作者:
Young Ho Jang;Tae Hun Lee;Ji Hun Jung;Sun Il Kwon;Won Mo Sung - 通讯作者:
Won Mo Sung
Sun Il Kwon的其他文献
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{{ truncateString('Sun Il Kwon', 18)}}的其他基金
Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
- 批准号:
10766104 - 财政年份:2023
- 资助金额:
$ 61.64万 - 项目类别:
Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
- 批准号:
10504837 - 财政年份:2022
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10299559 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10474466 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10689100 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
- 批准号:
10376047 - 财政年份:2020
- 资助金额:
$ 61.64万 - 项目类别:
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