Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
基本信息
- 批准号:10689205
- 负责人:
- 金额:$ 61.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAlgorithmsAnodesAreaBiomedical ResearchCherenkov RadiationClinicalComplementComputational algorithmDataData CollectionDetectionDevelopmentDiagnostic Neoplasm StagingDiscriminationDiseaseEventExcisionEyeFoundationsFutureGenerationsGeometryGlassGoalsHealthHospitalsImageImaging DeviceLeadLightLocationMachine LearningMeasuresMonte Carlo MethodNatureNoiseOpticsOutcomePatientsPerformancePhotonsPhysicsPositioning AttributePositronPositron-Emission TomographyPropertyRadiation Dose UnitRadioisotopesReaction TimeRefractive IndicesResolutionSamplingScanningSeriesSignal TransductionSystemTechniquesTechnologyThree-Dimensional ImageThree-Dimensional ImagingTimeTranslationsTubeVisionWorkbreast imagingclinical applicationclinical imagingclinical translationconvolutional neural networkdeep learningdesigndetection sensitivitydetectorflexibilityheart imaginghuman imagingimage reconstructionimaging platformimaging systemimprovedinnovationinstrumentationmachine learning algorithmnovelpersonalized carephotomultiplierportabilitypreservationprocess improvementprototyperadiotracerreal-time imagesreconstructionresponsescale upsignal processingsimulationtomographytooltreatment response
项目摘要
Project Summary/Abstract
A major advantage of coincidence detection of annihilation photons from positron-emitting radiotracers is the
availability of time-of-flight (TOF) information, and the ability to measure TOF differences to better localize the
positron emitter. Normally for positron emission tomography (PET), TOF information is used as a weighting
kernel during image reconstruction and results in an effective sensitivity gain that can be used to reduce radiation
dose, improve signal-to-noise ratio, or reduce scan duration. The magnitude of these benefits depend on the
TOF resolution, which is governed by the timing performance of the detectors. Current state of the art for PET
scanners is ~220 ps which corresponds to a localization of ~3.3 cm. A transformational change would occur,
however, if a TOF resolution of <30 ps could be achieved. This would localize events within 4.5 mm, allowing
images to be directly generated without a reconstruction algorithm at a spatial resolution that matches what is
achieved in clinical PET scanners today. We refer to this as direct positron emission imaging (PEI). With this
superb TOF resolution and reconstruction-free imaging, we enter a new regime where we expect major increases
in image signal-to-noise, both due to the additional TOF information, and the removal of noise amplification
inherent in reconstructing noisy data with noisy corrections from projection data. We propose to develop a first
proof-of-concept imaging system that uses ultra-fast detectors to directly produces cross-sectional images
without reconstruction and to quantify the performance of PEI both through simulations and experimentally.
Since direct PEI does not have the same sampling constraints for data collection as PET, it creates opportunities
for portable, and flexible imaging devices, with implications for patient-tailored or task-specific imaging
applications (i.e. cardiac or breast imaging), as well as open designs for general purpose applications.
To achieve the unprecedented TOF capabilities needed for direct PEI, we will exploit promptly emitted Cerenkov
radiation that is generated with <10 ps in certain materials, including scintillators, in response to a 511 keV
photon interaction. Our proposed novel detector design integrates a Cerenkov radiator directly into the entrance
window of an ultra-fast microchannel plate photomultiplier tube, which is the fastest photon detector currently
available with a response time of 25 ps. This approach eliminates all optical reflections between the point of light
generation and the photocathode, preserving the prompt timing nature of Cerenkov photons. We then combine
the integrated Cerenkov radiator detector with auxiliary photodetector read-out for robust coincidence detection,
and complement this with advanced signal processing algorithms we have pioneered using convolutional neural
networks to extract all possible timing information from the digitized detector waveforms and ultimately to perform
reconstruction-free imaging using only the digitized waveforms as input. In summary, we aim to prove that direct
PEI is possible, to characterize its properties and to provide the technological and algorithmic foundations for
eventual translation for human imaging.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Sun Il Kwon其他文献
The oil production performance analysis using discrete fracture network model with simulated annealing inverse method
- DOI:
10.1007/s12303-013-0034-y - 发表时间:
2013-07-05 - 期刊:
- 影响因子:1.500
- 作者:
Young Ho Jang;Tae Hun Lee;Ji Hun Jung;Sun Il Kwon;Won Mo Sung - 通讯作者:
Won Mo Sung
Sun Il Kwon的其他文献
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{{ truncateString('Sun Il Kwon', 18)}}的其他基金
Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
- 批准号:
10766104 - 财政年份:2023
- 资助金额:
$ 61.64万 - 项目类别:
Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
- 批准号:
10504837 - 财政年份:2022
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10299559 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10474466 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10689100 - 财政年份:2021
- 资助金额:
$ 61.64万 - 项目类别:
Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
- 批准号:
10376047 - 财政年份:2020
- 资助金额:
$ 61.64万 - 项目类别:
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