Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
基本信息
- 批准号:10376047
- 负责人:
- 金额:$ 36.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AreaBindingBiomedical ResearchBismuthBrainBreastDedicationsDetectionDoseElectronicsElectronsEventGamma RaysGenerationsGoalsHealthcareHumanImageImaging TechniquesLSO crystalLightMeasuresMethodsNoiseOpticsOutcomeOutputPerformancePhotonsPositron-Emission TomographyProcessProductionPropertyRadioactivityResolutionShapesSignal TransductionSiliconSurfaceSyncopeSystemTechnologyThickTimeVisualizationcostdesigndetectorimprovedluminescencemolecular diagnosticsnovelphotomultiplierphoton-counting detectortranslational medicine
项目摘要
SUMMARY
Positron emission tomography (PET) is widely used as a diagnostic molecular imaging technique and clearly
has had a significant impact on human healthcare. There have been significant improvements in PET technology
by employing time-of-flight (TOF) capability that measures the difference in arrival time of the two 511 keV
gamma annihilation rays. This TOF information spatially constrains the origin of the event, leading to improved
image quality due to the increased signal-to-noise ratio (SNR) and effective sensitivity in the PET scan.
The scintillator bismuth germanate (BGO), however, has several better properties for PET applications than
L(Y)SO, such as higher stopping power and higher photo-electric fraction. BGO also has no background activity
and can be produced at lower cost than L(Y)SO. However, a major drawback of BGO is the poor coincidence
timing resolution originating from the moderate light yield and slow decay time of scintillation photon production.
Therefore, BGO has not been considered for use in current generation TOF PET scanners.
Theoretically, when a 511keV gamma ray interacts in a scintillator, a small number of optical Cerenkov photons
are produced promptly by energetic electrons released by photoelectric or Compton interactions. The Cerenkov
photons are produced within an extremely short time frame and earlier than scintillation photons, Thus the
Cerenkov photons should provide better timing information for PET. Interestingly, BGO has properties that lead
to it producing more Cerenkov photons than other scintillators.
Recently, we showed, for the first time, the influence of prompt Cerenkov photons on the timing properties of
BGO using latest generation silicon photomultipliers (SiPMs) developed by our partner FBK. Thus, our proposed
concept for BGO is that Cerenkov photons are used to obtain prompt timing information while scintillation photons
provide essential energy information for PET. The major goals of this proposal are i) to improve coincidence
timing resolution of BGO by detecting more Cerenkov photons for TOF PET applications, ii) to develop signal
reducing methods and read-out electronics for signals generated by both Cerenkov and scintillation photons,
and iii) to finally develop and evaluate the first practical BGO-based TOF PET detector modules, which have 5
× 5 cm2 cross-sectional area and a coincidence timing resolution of ≤300 ps FWHM. If successful, this proposal
forms the basis for developing novel BGO-based TOF PET scanners with higher sensitivity and lower cost than
current PET scanners.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sun Il Kwon其他文献
The oil production performance analysis using discrete fracture network model with simulated annealing inverse method
- DOI:
10.1007/s12303-013-0034-y - 发表时间:
2013-07-05 - 期刊:
- 影响因子:1.500
- 作者:
Young Ho Jang;Tae Hun Lee;Ji Hun Jung;Sun Il Kwon;Won Mo Sung - 通讯作者:
Won Mo Sung
Sun Il Kwon的其他文献
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{{ truncateString('Sun Il Kwon', 18)}}的其他基金
Time-of-flight positron emission tomography using Cerenkov luminescence in bismuth germanate
使用锗酸铋中的切伦科夫发光进行飞行时间正电子发射断层扫描
- 批准号:
10766104 - 财政年份:2023
- 资助金额:
$ 36.9万 - 项目类别:
Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
- 批准号:
10689205 - 财政年份:2022
- 资助金额:
$ 36.9万 - 项目类别:
Reconstruction-free three dimensional positron emission imaging
免重建三维正电子发射成像
- 批准号:
10504837 - 财政年份:2022
- 资助金额:
$ 36.9万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10299559 - 财政年份:2021
- 资助金额:
$ 36.9万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10689100 - 财政年份:2021
- 资助金额:
$ 36.9万 - 项目类别:
High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography
基于超密快速陶瓷闪烁体的高性能且经济高效的探测器模块,用于长轴视场正电子发射断层扫描
- 批准号:
10474466 - 财政年份:2021
- 资助金额:
$ 36.9万 - 项目类别:
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