Administrative Core

行政核心为这项U19研究提供全面领导， 百岁老人及其后代对阿尔茨海默病的抵抗力/复原力 (RADCO)，它是NIA Science的3个核心和2个项目的通信枢纽 警官，单一内部审查机构和OSMB(区域反兴奋剂机构社区)的首席私人投资。其核心是 支持和鼓励RADCO社区之间的最佳互动，部分原因是 促进所有研究范围的、核心的和特定于项目的视频会议，并发布 在该研究的内部汇流网站上发布会议纪要和行动项目。核心提供 出版物和演示文稿及辅助研究委员会的领导以及 协调三年一次的RADCO范围的视频会议，讨论实现以下目标的进展 目的是向每个人通报其他人正在做什么和提供什么，特别是为青少年 调查人员，展示他们的工作的机会。在第二年和第四年，春季会议在 贝塞斯达的一个人。行政核心还与NIA工作人员协调，每年举行两次会议 与OSMB合作。核心通过创造引领着与更大的科学社区的联系 和维护RADCO面向公众的网站，并协调可供公众使用的 以及宣传良好的一年两次的科学研讨会。这些科学推广工作还包括 通过与NIA合作实施NIA的阿尔茨海默病相关数据共享政策 表型和生物标记物以及神经成像核心来执行质量控制、管理 并在数据发布后3个月内将所有生成的数据传输到AD知识门户 变得可用于分析。所有这些责任都是成功实现 这项拟议研究的目标重申为以下具体目标。

The Administrative Core provides the overall leadership for this U19 study, Resistance/Resilience to Alzheimer's Disease in Centenarians and their Offspring (RADCO) and it acts as the communication hub for the 3 cores and 2 projects, NIA scientific officers, the Lead PI for the Single IRB and the OSMB (the RADCO community). The core supports and encourages optimal interactions amongst the RADCO community in part by facilitating all of the study-wide, core- and project-specific video conference calls and posting the minutes and action items on the Study's internal Confluence-based website. The Core provides the leadership of the Publications and Presentations and Ancillary Studies Committees and orchestrates triannual RADCO-wide video conference meetings to discuss progress in achieving the aims, to update everyone on what others are doing and provides, particularly for junior investigators, opportunities to present their work. In years 2 and 4, the Spring meeting is held in person in Bethesda. The Administrative Core also coordinates with NIA staff, biannual meetings with the OSMB. The Core leads the outreach to the greater scientific community with the creation and maintenance of the RADCO's public facing website and orchestration of publicly available and well-advertised biannual scientific workshops. These scientific outreach efforts also include implementation of NIA's Alzheimer's Disease-related data sharing policy by working with the Phenotyping and Biospecimen and the Neuroimaging Cores to perform quality control, curation and transfer of all generated data to the AD Knowledge Portal within 3 months of the data becoming available for analyses. All of these responsibilities are integral to successfully achieving the goals of the proposed research and they are reiterated as the following specific aims.