Administrative Core

项目总结管理核心 成瘾系统神经遗传学中心(CSNA)融合了高级实验和计算 在复杂的小鼠模型系统中与行为神经科学、计算专家合作的方法 生物学和遗传学，询问精神刺激剂潜在风险的重叠生物因素 上瘾。CSNA借鉴了三位非常有成就的研究人员的经验和专业知识 在杰克逊实验室(JAX)、纽约州立大学宾厄姆顿大学和北卡罗来纳大学教堂 小山。通过资源共享、实验和分析标准化来整合这些计划， 和协作，CSNA将能够对精神刺激剂的风险进行协同、多维度的分析 滥用，同时与研究界共享数据、资源和专业知识。要充分利用 由这个地理上分散的团队提供的广泛的知识库，并有效地综合和 传播新的方法、调查结果和教育机会，CSNA将得到一个强大的、 集中且组织良好的管理核心(管理核心)。管理核心的总体目标 主要有：1)沟通。行政核心将组织和监督定期的科学会议，以促进 在CSNA的项目和核心内部和之间进行沟通和协同，并培养一个强大的、 跨所有站点的协作环境，包括JAX外部的站点。两国之间定期沟通 行政核心领导，由PI和所有核心和项目组成的内部执行委员会(IEC) Leads和由该领域专家组成的外部咨询委员会(EAB)将优化 CSNA致力于实现其目标，并将中心作为具有国家影响力的资源进行管理。2) 监督/管理。行政核心将为CSNA提供科学和行政监督 研究项目、核心和试点项目。这种监督将包括评估和决策， 项目管理， 及时编写报告、定期财务审查、知识产权管理、 合规、机构和方案资源的参与、试点项目审查以及 定期审查研究和出版进度。作为其监督和计划审查的一部分，EAB将 提供对CSNA进展的批判性观点，对总体科学方向提出建议，以及 就中心面临的后勤、科学和财政挑战提供指导。管理核心，一起 与IEC一起，负责EAB建议的实施。3)教育、外展和职业 发展。管理核心将提供外展，以进一步提高公众对成瘾研究和 CSNA并加强在成瘾遗传学方面的专业培训、教育和职业发展 一支多元化的成瘾研究队伍。这将通过一套利用 日本宇宙航空研究开发机构现有的用于教育和外联的成熟资源。

PROJECT SUMMARY ADMINISTRATIVE CORE The Center for Systems Neurogenetics of Addiction (CSNA) merges advanced experimental and computational approaches in sophisticated mouse model systems with experts in behavioral neuroscience, computational biology and genetics, to interrogate the overlapping biological factors underlying risk for psychostimulant addiction. The CSNA draws on the experience and expertise of three highly accomplished researchers based at The Jackson Laboratory (JAX); SUNY–Binghamton University; and the University of North Carolina Chapel Hill. By integrating these programs through resource sharing, experimental and analytical standardization, and collaboration, the CSNA will enable a synergistic, multi-dimensional analysis of risk for psychostimulant abuse, while sharing data, resources and expertise with the research community. To fully capitalize on the extensive knowledge base afforded by this geographically dispersed team, and to efficiently synthesize and disseminate novel methods, findings and educational opportunities, the CSNA will be guided by a strong, centralized and well-organized Administrative Core (Admin Core). The overall objectives of the Admin Core are: 1) Communication. The Admin Core will organize and oversee regular scientific meetings to foster communication and synergy within and across the projects and cores of the CSNA, and to nurture a strong, collaborative environment across all sites, including those external to JAX. Regular communication between Admin Core leadership, the Internal Executive Committee (IEC) composed of the PI and all Core and Project Leads, and an External Advisory Board (EAB) composed of experts in the field, will optimize both progress of the CSNA towards its goals and stewardship of the Center as a resource of national impact. 2) Oversight/Management. The Admin Core will provide scientific and administrative oversight of CSNA research projects, cores and pilot programs. This oversight will include assessment and decision-making, project management, timely preparation of reports, regular fiscal review, intellectual property management, regulatory compliance, involvement of institutional and programmatic resources, pilot project review, and regular review of research and publication progress. As part of its oversight and program review, the EAB will provide critical perspectives on CSNA progress, make recommendations on overall scientific direction, and provide guidance on logistic, scientific and fiscal challenges faced by the Center. The Admin Core, together with the IEC, are responsible for implementation of EAB recommendations. 3) Education, Outreach and Career Development. The Admin Core will provide outreach to further public awareness of addiction research and of the CSNA and enhance professional training, education and career development in the genetics of addiction for a diversified addiction research workforce. This will be accomplished through a suite of offerings that leverage the well-established resources available at JAX for education and outreach.