A framework for feasible translation to enhance foot and ankle function in aging and mobility
一个可行的翻译框架,以增强足部和脚踝在衰老和活动中的功能
基本信息
- 批准号:10704158
- 负责人:
- 金额:$ 53.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgeAgingAnkleBenchmarkingBioenergeticsBiomechanicsClinicalClinical ManagementDataDevicesDistalElastic TissueElasticityElderlyEnergy consumptionExhibitsFlexorFoot joint structureGaitGenerationsHumanImpairmentInstitutionIntramuscularLocomotionMeasurableMeasurementMechanicsMetabolicMetatarsal bone structureModelingModificationMotor ActivityMuscleOutcomeOutputPerformancePhalanxPhasePlayProductivityPublic HealthQuality of lifeRegulationResearchResearch InfrastructureResearch PersonnelRoleSelf-Help DevicesSeriesShoesSpeedStructureSystemTestingTissue imagingTranslationsUltrasonographyWalkingWorkachilles tendonage effectage relatedaging populationankle jointaponeurosiscarbon fibercostcost comparisoncost effectivedesignefficacy testingelectromyographic biofeedbackfootfunctional disabilityimprovedimproved mobilityin vivoinsightjoint functionjoint stiffnessmechanical energymuscle strengthnegative affectnovelpeerresponsestrength trainingtranslational potentialtransmission processyoung adult
项目摘要
PROJECT SUMMARY
This proposal will address the critical need for new and modifiable targets to enhance mobility and restore
independence to those in our rapidly aging population. Due to reduced ankle push-off power, older adults walk
slower and with higher metabolic energy cost than younger adults. As our central premise, we contend that
hallmark age-associated deficits in push-off intensity during walking have been far too often mistakenly
attributed solely to the plantarflexor muscles, and instead originate interdependently with those in the active,
passive, and structural regulation of foot mechanical power. This premise paves the way for translational
opportunities to augment foot structure and function to enhance independence and quality of life. This study
combines the research agendas of two highly productive investigators and leverages the research infrastructure
of two peer institutions. Aim 1 will be the first to study mechanical power interactions between the human foot
and ankle in governing reduced push-off intensity and walking economy in older adults across a wide variety of
everyday walking tasks. By combining metabolic measurements with state-of-the-art biomechanical and
bioenergetic modeling, we will test the hypothesis that older adults exhibit higher mechanical energy losses via
foot structures than young adults – aging effects that: (i) are larger for walking tasks that increase foot demand,
(ii) misappropriate ankle moment and power during push-off, and thereby (iii) correlate with shorter 6 min walk
distance and increased metabolic energy cost compared to young adults. Aim 2 will provide mechanistic insight
into aging effects on the active, passive, and structural regulation of foot-ankle mechanical power interactions
during walking. Using a series of controlled loading paradigms on a dynamometer combined with advanced in
vivo ultrasound imaging and novel electromyographic biofeedback, we will test the hypotheses that older adults
exhibit: (i) reduced foot and plantarflexor muscle strength and (ii) lower structural stiffness of and (iii) reduced
structural connectivity between series elastic tissues spanning the foot and ankle – changes that require elevated
plantar intrinsic muscle activation to maintain requisite foot stiffness and associate with reduced ankle moment
and power output during push-off in walking. Finally, as a translational benchmark, Aim 3 will show that shoe-
stiffness modifications that act in parallel with the plantar aponeurosis and intrinsic muscles can mitigate age-
associated deficits in push-off function during walking. Supported by promising pilot data, we will test the
hypotheses that older adults walking with increased shoe insole stiffness will exhibit: (i) smaller mechanical
energy losses at the foot, (ii) more favorable plantarflexor muscle contractile dynamics, (iii) greater peak ankle
moment and power output, and thus (iv) longer 6 min walk distance and reduced whole-body metabolic energy
cost. Ultimately, this work will establish a paradigm shift in our biomechanical understanding and clinical
management of age-related mobility impairment toward feasible and cost-effective devices to modify foot-ankle
function – an outcome with significant potential to enhance independence and quality of life for millions.
项目摘要
本提案将满足对新的和可修改的目标的迫切需求,以增强机动性和恢复能力,
在我们迅速老龄化的人口中独立。由于踝关节蹬离力降低,老年人步行
比年轻的成年人更慢,代谢能量消耗更高。作为我们的中心前提,我们认为,
在行走过程中,与年龄相关的蹬离强度缺陷常常被错误地认为是
仅归因于跖屈肌,而是与活动中的那些肌肉相互依赖地起源,
被动的和结构性的足部机械动力调节。这一前提为翻译铺平了道路
增加足部结构和功能的机会,以提高独立性和生活质量。本研究
结合了两位高效率研究人员的研究议程,并利用研究基础设施
两个同行机构。目标1将是第一个研究人类足部之间的机械动力相互作用的项目。
和踝关节在控制减少推离强度和步行经济性的老年人在各种各样的,
每天的行走任务。通过将代谢测量与最先进的生物力学和
生物能量模型,我们将测试的假设,老年人表现出较高的机械能损失,通过
足部结构比年轻成人-老化效应:(i)对于增加足部需求的行走任务更大,
(ii)蹬地过程中踝关节力矩和力量不当,因此(iii)与6分钟步行时间缩短相关
与年轻人相比,距离和代谢能量成本增加。目标2将提供机械见解
老化对足踝机械动力相互作用的主动、被动和结构调节的影响
在走路的时候。在测力计上使用一系列受控加载范例,
体内超声成像和新的肌电生物反馈,我们将测试的假设,老年人
表现出:(i)降低的足和跖屈肌肌肉强度和(ii)降低的结构刚度和(iii)降低的
跨越足部和脚踝的一系列弹性组织之间的结构连接性-需要升高的变化
足底固有肌激活以维持必要的足部刚度并与减少的踝关节力矩相关
和行走时蹬离时的动力输出。最后,作为一个翻译基准,目标3将表明,鞋-
与足底腱膜和内在肌肉平行作用的刚度修改可以减轻年龄,
行走时推离功能的相关缺陷。在有希望的试点数据的支持下,我们将测试
假设老年人在鞋垫刚度增加的情况下行走将表现出:(i)较小的机械强度,
足部能量损失,(ii)更有利的跖屈肌收缩动力学,(iii)更大的踝关节峰值
力矩和功率输出,因此(iv)6分钟步行距离延长,全身代谢能量减少
成本最终,这项工作将在我们的生物力学理解和临床实践中建立一个范式转变。
管理与年龄相关的活动障碍,采用可行且具有成本效益的设备来修改足踝
功能-这一成果具有提高数百万人的独立性和生活质量的巨大潜力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jason R Franz其他文献
Jason R Franz的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jason R Franz', 18)}}的其他基金
A framework for feasible translation to enhance foot and ankle function in aging and mobility
一个可行的翻译框架,以增强足部和脚踝在衰老和活动中的功能
- 批准号:
10501648 - 财政年份:2022
- 资助金额:
$ 53.7万 - 项目类别:
The peripheral motor repertoire as a neuromuscular constraint on walking balance integrity in age-related falls risk
外周运动指令作为神经肌肉约束对年龄相关跌倒风险中步行平衡完整性的影响
- 批准号:
10266818 - 财政年份:2020
- 资助金额:
$ 53.7万 - 项目类别:
In vivo Manipulation of Mechanical Loading: Using Real-time Biofeedback to Strategically Understand the Acute Biomechanical, Biochemical and Structural Changes Induced by Lower Extremity Loading
机械负荷的体内操纵:利用实时生物反馈有策略地了解下肢负荷引起的急性生物力学、生化和结构变化
- 批准号:
9762843 - 财政年份:2018
- 资助金额:
$ 53.7万 - 项目类别:
Dynamic imaging to guide wearable robotic intervention for enhanced mobility in aging
动态成像指导可穿戴机器人干预以增强衰老过程中的活动能力
- 批准号:
9920637 - 财政年份:2018
- 资助金额:
$ 53.7万 - 项目类别:
Dynamic imaging to guide wearable robotic intervention for enhanced mobility in aging
动态成像指导可穿戴机器人干预以增强衰老过程中的活动能力
- 批准号:
10402260 - 财政年份:2018
- 资助金额:
$ 53.7万 - 项目类别:
Dynamic imaging to guide wearable robotic intervention for enhanced mobility in aging
动态成像指导可穿戴机器人干预以增强衰老过程中的活动能力
- 批准号:
9750576 - 财政年份:2018
- 资助金额:
$ 53.7万 - 项目类别:
Dynamic imaging to guide wearable robotic intervention for enhanced mobility in aging
动态成像指导可穿戴机器人干预以增强衰老过程中的活动能力
- 批准号:
10209130 - 财政年份:2018
- 资助金额:
$ 53.7万 - 项目类别:
The Sensorimotor Locus of Balance Control in Elderly Gait
老年人步态平衡控制的感觉运动轨迹
- 批准号:
9566373 - 财政年份:2017
- 资助金额:
$ 53.7万 - 项目类别:
Mechanics of the Aging Achilles tendon with implications for walking performance
老化跟腱的力学对步行性能的影响
- 批准号:
8524190 - 财政年份:2013
- 资助金额:
$ 53.7万 - 项目类别:
Mechanics of the Aging Achilles tendon with implications for walking performance
老化跟腱的力学对步行性能的影响
- 批准号:
8701027 - 财政年份:2013
- 资助金额:
$ 53.7万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 53.7万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 53.7万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 53.7万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 53.7万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 53.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 53.7万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 53.7万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 53.7万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 53.7万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 53.7万 - 项目类别:
Miscellaneous Programs