课题基金 / 基金详情

The Sensorimotor Locus of Balance Control in Elderly Gait

The Sensorimotor Locus of Balance Control in Elderly Gait
老年人步态平衡控制的感觉运动轨迹
批准号:
9566373
负责人:
Jason R Franz
金额:
$22.77万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-30 至 2019-08-31

项目摘要

项目成果

Jason R Franz的其他基金

相似基金

相关文献

中文摘要
翻译
我们的老龄化人口是在衰弱性跌倒的风险异常高,有助于显著减少
英文摘要
Our aging population is at an exceptionally high risk of debilitating falls, contributing significantly to reduced independence and quality of life. Despite conventional diagnostic and rehabilitative efforts, one-third of people over age 65 fall annually and 20-30% of these falls lead to moderate to severe injury. Remarkably, evidence even suggests that the rate of injurious falls among older adults is accelerating. Through an innovative sensorimotor paradigm using optical flow perturbations in a custom virtual environment, this proposal seeks to address the critical and immediate need for transformative new approaches for identifying and mitigating falls risk in our aging population. Our overarching goal is to investigate the efficacy of optical flow perturbations, particularly when applied during walking, to: (i) elucidate aging and falls history effects on standing and walking balance control, and (ii) subsequently condition successful balance control strategies through training. The first aim will tightly integrate virtual reality, visuomotor entrainment (i.e., the instinctive synchronization of motor responses to visual stimuli), and a series of clinical and self-reported benchmarks to investigate aging and falls history effects on the response to optical flow perturbations during standing and walking. We will test the hypothesis that optical flow perturbations during walking will distinguish age and falls history more effectively than those during standing and with effect sizes larger than those from conventional balance testing. The second aim will investigate sensory, motor, and cognitive-motor mechanisms governing susceptibility to optical flow perturbations. Using a strategically-selected combination of outcome measures and multivariate modeling, we will test the hypothesis that entrainment to optical flow perturbations will correlate most strongly with visual dependence and decreased somatosensory function, alluding to an age-associated process of multi-sensory reweighting that will emerge most prominently in walking. Finally, our third aim is designed to gain preliminary insight into the efficacy of prolonged optical flow perturbations to condition strategies used to successfully control walking balance in older adult fallers. In a randomized cross-over design, older adults with a history of falls will complete two treadmill training sessions – one with (i.e., “training” session) and one without (i.e., “control” session) dynamic optical flow perturbations. We will test the hypothesis that older adults with a history of falls will adapt to prolonged exposure to perturbations, conditioning their step to step adjustments in walking balance control and improving their response to unexpected balance challenges following training. This research represents an interdisciplinary collaboration involving experienced investigators in biomedical engineering, physical therapy, and motor control. Successful completion of this R21 will provide the necessary mechanistic and preliminary efficacy information needed to design larger diagnostic and intervention studies to determine the value and applicability of perturbed optical flow to mitigate fall risk. With the advent of wearable and low cost virtual reality technology, this proposal is both timely and clinically feasible.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.clinbiomech.2018.09.011
发表时间: 2018-11
期刊: Clinical biomechanics (Bristol, Avon)
影响因子: --
作者: [Thompson JD, Plummer P, Franz JR]
通讯作者: Franz JR
DOI: 10.1016/j.gaitpost.2018.03.011
发表时间: 2018
期刊: Gait & posture
影响因子: 2.4
作者: [Qiao,Mu, Truong,KinhN, Franz,JasonR]
通讯作者: Franz,JasonR
Effects of aging and target location on reaction time and accuracy of lateral precision stepping during walking.
老化和目标位置对步行过程中横向精确步进的反应时间和准确性的影响。
DOI: 10.1016/j.jbiomech.2020.109710
发表时间: 2020
期刊: Journal of biomechanics
影响因子: 2.4
作者: [Selgrade,BrianP, Childs,MarcusE, Franz,JasonR]
通讯作者: Franz,JasonR
Time-dependent tuning of balance control and aftereffects following optical flow perturbation training in older adults.
老年人光流扰动训练后平衡控制和后遗症的时间依赖性调整。
DOI: 10.1186/s12984-019-0555-3
发表时间: 2019
期刊: Journal of neuroengineering and rehabilitation
影响因子: 5.1
作者: [Richards,JacksonT, Selgrade,BrianP, Qiao,Mu, Plummer,Prudence, Wikstrom,ErikA, Franz,JasonR]
通讯作者: Franz,JasonR
A framework for feasible translation to enhance foot and ankle function in aging and mobility
A framework for feasible translation to enhance foot and ankle function in aging and mobility
The peripheral motor repertoire as a neuromuscular constraint on walking balance integrity in age-related falls risk
海外基金