Modeling Health Histories and the Dynamics of Social Inequality in a Nonhuman Primate Population

对非人类灵长类动物群体的健康史和社会不平等动态进行建模

• 批准号: 10704503
• 负责人: Raisa Hernandez Pacheco
• 金额: $ 21万
• 依托单位: CALIFORNIA STATE UNIVERSITY LONG BEACH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704503
• 关键词: Address; Adult; Affect; Age; Aging; Automobile Driving; Basic Science; Biological Markers; Biological Models; Body mass index; Cessation of life; Chronic stress; Cognitive; Complex; Data; Data Collection; Data Set; Demography; Development; Differential Mortality; Dimensions; Disadvantaged; Disparity population; Emotional; Entropy; Equilibrium; Ethnic Origin; Exhibits; Exposure to; Female; Formulation; Fostering; Future; Gender; Goals; Health; Health Transition; Heterogeneity; Homologous Gene; Human; Impaired cognition; Individual; Inequality; Injury; Interruption; Intervention; Life; Life Cycle Stages; Longevity; Longitudinal Studies; Macaca; Macaca mulatta; Measures; Methods; Modeling; Modification; Outcome; Pattern; Performance; Phenotype; Physiological; Population; Primates; Probability; Puerto Rico; Race; Recording of previous events; Recovery; Reduce health disparities; Relapse; Research; Risk; Severities; Short-Term Memory; Social Characteristics; Social Environment; Social status; Social stratification; Socioeconomic Status; Structure; Subgroup; System; Testing; Time; Translating; Translational Research; United States National Institutes of Health; Visit; Weight; Work; absorption; age related; cognitive task; comparative; data structure; density; executive function; experience; flexibility; follow-up; health disparity; healthy aging; human data; human population study; improved; indexing; male; mortality; nonhuman primate; psychologic; sex; social; social attention; social disparities; social health determinants; social integration; theories; therapy development; trend

Project Summary The broad goal of the proposed project is to increase understanding of the dynamics of socially driven health disparities by developing improved methods to forecast individual health histories using a new primate model exposed to different levels of social disadvantage. Health disparities across different subgroups are a crucial societal problem1-3 and thus, accurate models describing and forecasting individual health histories are a fundamental first step to identify strategies for intervention. Most current models4-5 assume that the observed gradual accumulation of health decline in human populations reflect the change in the health history of individuals across their lifespan. However, recent work on functional limitations6 suggests that individual health histories are better described as a punctuated equilibrium pattern where the individual may experience periods of long-term stability interrupted by sudden changes. This points towards discrepancies between models used to test hypotheses about the impact of cumulative disadvantage over the lifespan, and the actual health histories experienced by individuals. To narrow the health gap and thus foster healthy aging across all groups, the theoretical and practical limitations imposed by current health history forecast methods must be overcome. This project aims to improve analytical understanding of health disparity dynamics by employing a comparative approach using data from the Cayo Santiago rhesus macaque population. This population uniquely allows for integrative longitudinal studies of health in a naturalistic, socially complex population, and thus is an ideal primate model system to yield information about how different individuals transition between multiple states of health across the socially stratified adult lifespan. The first aim is to characterize transition rules between multiple states of health across the socially stratified adult lifespan using indexes of health comprising both psychological and physiological health. The second aim is to use this new empirical dataset to formulate and develop a multistate forecasting model to analyze changing patterns of health and their relation to an individual’s social environment. The third aim is to then forecast cumulative health penalties and divergent health outcomes in order to identify stable or changing gaps in health across subgroups exposed to different levels of social disadvantage, such as social status and social integration. These aims will allow the formulation of an accurate dynamic health history forecast model, the examination of whether and how individual sociality affects health state transitions across sex and age, and ultimately the refinement, modification, and adaptation of data collection and current model assumptions for accurate assessment of socially driven health disparities. Specifically, this study will contribute to the NIH Stage 0 of Intervention Development through basic science, opening space to identify critical ages to target in a follow-up longitudinal study that will provide a crucial bridge to future translational research with humans.

项目摘要 拟议项目的广泛目标是增加对社会驱动的健康动态的理解 通过开发改进的方法，使用新的灵长类动物模型预测个体健康史， 面临着不同程度的社会劣势。不同亚群之间的健康差异是一个关键因素， 社会问题1 -3，因此，描述和预测个人健康史的准确模型是一个 确定干预战略的基本第一步。目前大多数模型4 -5都假设观察到的 人群中健康下降的逐渐积累反映了个体健康史的变化 在他们的生命周期中。然而，最近关于功能限制的研究表明，个体健康史是 更好地描述为一个间断的平衡模式，其中个人可能会经历长期的 被突然的变化打断的稳定。这表明用于测试的模型之间存在差异 关于累积不利因素对寿命的影响的假设，以及实际的健康史 个人经历的。为了缩小健康差距，从而促进所有群体的健康老龄化， 必须克服当前健康史预测方法所带来的理论和实践局限性。 该项目旨在通过采用比较方法，提高对健康差距动态的分析理解。 方法使用来自Cayo圣地亚哥恒河猴种群的数据。这个群体独特地允许 综合纵向研究健康的自然主义，社会复杂的人口，因此是一个理想的灵长类动物 模型系统，以产生关于不同个体如何在多种健康状态之间转变的信息 在社会分层的成年人的一生中。第一个目标是描述多个状态之间的转换规则 在整个社会分层的成人寿命的健康指数，包括心理和 生理健康第二个目标是使用这个新的经验数据集来制定和发展一个多状态 预测模型来分析健康的变化模式及其与个人社会环境的关系。 第三个目标是预测累积的健康惩罚和不同的健康结果，以确定 处于不同程度社会不利地位的亚群体之间的健康差距稳定或不断变化， 社会地位和社会融合。这些目标将允许制定一个准确的动态健康史 预测模型，检查个人社会性是否以及如何影响健康状态的转变， 性别和年龄，并最终完善，修改和调整数据收集和当前模型 准确评估社会驱动的健康差距的假设。具体而言，这项研究将有助于 通过基础科学进入NIH干预发展的第0阶段，为确定关键年龄开辟空间， 这将为未来的翻译研究提供重要的桥梁， 人类