Colorado HNC SPORE Data Sciences Core

数据科学核心概述 科罗拉多大学头颈癌(CO HNC)孢子数据科学核心(DSC)提供 为生物统计、信息学、生物信息学和其他数据科学相关分析提供服务。DSC工作人员是 由5名博士和1名硕士级别的研究人员组成，他们共同提供了丰富的临床专业知识 试验设计和分析；统计遗传学；多组学数据分析；软件开发；预测性 建模；以及以癌症为重点的生物信息学。核心包括一支全面的生物统计学家团队， 生物信息学家和流行病学家，形成了研究人员的中心，他们的共同点是 通过现有的合作从事HNC研究。DSC的总体目标是建立一个 与HNC数据科学相关的实践社区。所有工作人员都由 DSC主任，高德祥博士，和CO HNC孢子中的所有教职员工一样，DSC教职员工是 科罗拉多大学癌症中心(UCCC)，特别是生物统计学和生物信息学共享 资源(BBSR)。BBSR与头颈研究团队有着长期的合作历史 在过去的10年里。学院生物统计学家和生物信息学家致力于开发新的 增强HNC孢子的方法和工具。自2015年以来，DSC内部的教职员工发布了~20个同行- 审阅了手稿(另外5份正在准备中)，并与9份同行审阅的校外R01进行了合作 与HNC孢子调查人员的拨款，其中4个是现役奖项。通过利用这些既定的 通过协作，DSC可以有效和高效地支持CO HNC孢子项目。整合人员 在一个核心内支持所有孢子计划将最大限度地利用可用资源来增加DSC的科学 冲击力。具体来说，DSC将在研究假设的制定、临床试验设计、 样本量确定、分析和数据库设计、数据收集、分析、管理和存储。 这种支持将通过管理和协调积累的研究和临床数据来继续 与关键定量结果相关的分析、手稿准备和临床试验报告的协助 和严谨的科学结论。因此，DSC将在临床试验和基础科学中发挥关键作用 和翻译研究。

SUMMARY, Data Science Core The University of Colorado Head and Neck Cancer (CO HNC) SPORE Data Science Core (DSC) provides services for biostatistics, informatics, bioinformatics, and other data science related analyses. The DSC staff is comprised of five Ph.D. and one Master’s level researchers who collectively offer substantial expertise in clinical trial design and analysis; statistical genetics, multi-omics data analysis; software development; predictive modeling; and cancer-focused bioinformatics. The core includes a comprehensive team of biostatisticians, bioinformaticians, and an epidemiologist, that form a hub of researchers with the common denominator of being engaged in HNC research through exisiting collaborations. The DSC has the overarching objective to build a community of practice related to HNC data science. All staff are operationally managed and overseen by the DSC Director, Dexiang Gao Ph.D, and like all faculty in the CO HNC SPORE the DSC faculty are members of the University of Colorado Cancer Center (UCCC), specifically the Biostatistical and Bioinformatics shared resource (BBSR). The BBSR has a long-standing history of collaboration with the Head and Neck research team over the past 10 years. Faculty biostatisticians and bioinformaticians are engaged in the development of novel methods and tools that enhance the HNC SPORE. Since 2015, faculty within the DSC published ~20 peer- reviewed manuscripts (with an additional 5 in preparation) and collaborated on 9 peer-reviewed extramural R01 grants with HNC SPORE investigators, 4 of which are active awards. By harnessing these established collaborations, the DSC can effectively and efficiently support CO HNC SPORE projects. Integrating personnel within a Core to support all SPORE programs will maximize available resources to increase the DSC’s scientific impact. Specifically, the DSC will provide assistance with research hypotheses formulation, clinical trial designs, sample size determination, analytical and database design, data collection, analyses, management and storage. This support will continue through management and coordination of accumulating research and clinical data analyses, assistance with manuscript preparation and clinical trial reports in relation to key quantitative findings and rigorous scientific conclusions. Thus, the DSC will play a critical role in clinical trials, as well as basic science and translational studies.