Colorado HNC SPORE Data Sciences Core

科罗拉多州 HNC SPORE 数据科学核心

• 批准号: 10704585
• 负责人: Dexiang Gao
• 金额: $ 13.46万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704585
• 关键词: Animal Experiments; Area; Award; Basic Science; Bioinformatics; Bioinformatics Shared Resource; Biological Markers; Biometry; Categories; Cells; Clinic; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Colorado; Communication; Community of Practice; Data Analyses; Data Collection; Data Science; Data Science Core; Development; Doctor of Philosophy; Ensure; Epidemiologist; Evaluation; Experimental Designs; Extramural Activities; Faculty; Focus Groups; Formulation; Genetic; Genetic Transcription; Genomics; Grant; Head and Neck Cancer; Head and neck structure; Human Resources; Immunological Models; Immunotherapy; In Vitro; Informatics; Investigation; Laboratories; Lead; Leadership; Link; Malignant Neoplasms; Manuscripts; Methods; Mission; Multiomic Data; Mus; Observational Study; Outcome; Paper; Pathology; Peer Review; Play; Population Study; Predictive Value; Preparation; Process; Proteins; Proteomics; Publishing; Radiation; Recording of previous events; Reporting; Reproduction spores; Research; Research Design; Research Methodology; Research Personnel; Research Support; Resources; Retrieval; Ribosomes; Role; Sample Size; Services; Speed; Statistical Models; Structure; T cell receptor repertoire sequencing; T-Lymphocyte; Techniques; Testing; The University of Colorado Cancer Center; Therapeutic; Translating; Translation Process; Translational Research; Universities; anticancer research; career; data management; database design; density; design; effectiveness research; electronic data capture system; experience; experimental study; improved; in vivo; individual responsibility; innovation; large datasets; member; next generation; novel; pre-clinical research; preclinical study; predictive modeling; prognostic value; programs; quality assurance; response; single cell mRNA sequencing; single-cell RNA sequencing; small molecule; software development; therapeutic target; tool; trafficking; translational study; whole genome

SUMMARY, Data Science Core The University of Colorado Head and Neck Cancer (CO HNC) SPORE Data Science Core (DSC) provides services for biostatistics, informatics, bioinformatics, and other data science related analyses. The DSC staff is comprised of five Ph.D. and one Master’s level researchers who collectively offer substantial expertise in clinical trial design and analysis; statistical genetics, multi-omics data analysis; software development; predictive modeling; and cancer-focused bioinformatics. The core includes a comprehensive team of biostatisticians, bioinformaticians, and an epidemiologist, that form a hub of researchers with the common denominator of being engaged in HNC research through exisiting collaborations. The DSC has the overarching objective to build a community of practice related to HNC data science. All staff are operationally managed and overseen by the DSC Director, Dexiang Gao Ph.D, and like all faculty in the CO HNC SPORE the DSC faculty are members of the University of Colorado Cancer Center (UCCC), specifically the Biostatistical and Bioinformatics shared resource (BBSR). The BBSR has a long-standing history of collaboration with the Head and Neck research team over the past 10 years. Faculty biostatisticians and bioinformaticians are engaged in the development of novel methods and tools that enhance the HNC SPORE. Since 2015, faculty within the DSC published ~20 peer- reviewed manuscripts (with an additional 5 in preparation) and collaborated on 9 peer-reviewed extramural R01 grants with HNC SPORE investigators, 4 of which are active awards. By harnessing these established collaborations, the DSC can effectively and efficiently support CO HNC SPORE projects. Integrating personnel within a Core to support all SPORE programs will maximize available resources to increase the DSC’s scientific impact. Specifically, the DSC will provide assistance with research hypotheses formulation, clinical trial designs, sample size determination, analytical and database design, data collection, analyses, management and storage. This support will continue through management and coordination of accumulating research and clinical data analyses, assistance with manuscript preparation and clinical trial reports in relation to key quantitative findings and rigorous scientific conclusions. Thus, the DSC will play a critical role in clinical trials, as well as basic science and translational studies.

摘要，数据科学核心 科罗拉多大学头颈癌（CO HNC）SPORE数据科学核心（DSC）提供 生物统计学、信息学、生物信息学和其他数据科学相关分析服务。DSC的工作人员是 由五位博士组成和一个硕士水平的研究人员谁共同提供大量的专业知识，在临床 试验设计和分析;统计遗传学，多组学数据分析;软件开发;预测 建模;以及以癌症为中心的生物信息学。核心包括一个全面的生物统计学家团队， 生物信息学家和流行病学家，形成了一个研究人员的中心，其共同点是 参与HNC的研究通过认证合作。DSC的总体目标是建立一个 与HNC数据科学相关的实践社区。所有工作人员的业务管理和监督均由 DSC主任，高德祥博士，和CO HNC SPORE的所有教师一样，DSC教师是 科罗拉多大学癌症中心（UCCC），特别是生物统计学和生物信息学共享 资源（BBSR）。BBSR与头颈部研究团队有着悠久的合作历史 在过去的10年里。学院生物统计学家和生物信息学家从事新的发展， 增强HNC SPORE的方法和工具。自2015年以来，DSC内的教师发表了约20同行- 审查了手稿（另有5份正在准备中），并合作完成了9份同行评审的校外R 01 与HNC SPORE调查人员的赠款，其中4项是有效的奖励。通过利用这些已建立的 通过合作，DSC可以有效地支持CO HNC SPORE项目。整合人员 在一个核心内支持所有的SPORE计划将最大限度地利用可用资源，以增加DSC的科学性， 冲击具体而言，DSC将提供研究假设制定，临床试验设计， 样本量确定、分析和数据库设计、数据收集、分析、管理和存储。 这种支持将通过管理和协调不断积累的研究和临床数据而继续下去 分析、协助撰写与关键定量结果相关的手稿和临床试验报告 严谨的科学结论。因此，DSC将在临床试验和基础科学中发挥关键作用 和翻译研究。