Engagement Core

参与核心

• 批准号: 10704662
• 负责人: MONICA G. RIVERA-MINDT
• 金额: $ 761.18万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704662
• 关键词: Acculturation; Address; Adult; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-Protein; Appointment; Biological; Biological Factors; Biological Markers; Black race; Blood Vessels; Clinic; Clinical; Clinical Trials; Cognitive; Communities; Dedications; Dementia; Disclosure; Disparate; Disparity; Education; Effectiveness; Elderly; Equity; Ethnic Origin; Etiology; Evaluation; Exclusion Criteria; Frequencies; Funding; Goals; Health Disparities Research; Health Priorities; Hematological Disease; Image; Impaired cognition; Incentives; Individual; Language; Latinx; Linguistics; Magnetic Resonance Imaging; Measures; Medical; Mentors; Methods; Participant; Persons; Population Group; Positron-Emission Tomography; Psychological Factors; Public Health; Recommendation; Remunerations; Research; Research Methodology; Research Personnel; Role; Sampling; Site; Social Network; System; Training; Triage; Trust; Underrepresented Populations; Update; Work; career; cohort; community based participatory research; community engaged research; community organizations; community partnership; community science; comorbidity; cultural competence; dementia risk; demographics; depressive symptoms; digital; eligible participant; evidence base; expectation; health disparity; improved; innovation; low socioeconomic status; neuroimaging; psychologic; public health priorities; recruit; recruitment science; screening; social adversity; social culture; sociocultural determinant; success; tau Proteins; translational engagement; vascular cognitive impairment and dementia

Dementia disparities are a major and rapidly escalating public health threat. For instance, Black and Latinx adults are up to three times as likely to develop Alzheimer’s disease (AD) compared to non-Latinx whites (NLW), yet they remain greatly underrepresented in research. Further, underrepresented populations (URPs; e.g., Black, Latinx; low SES) also bear a disparate burden of biological and sociocultural vulnerabilities that confer increased dementia risk, but dementia etiologies and the role of such vulnerabilities remain poorly understood. In addition, community-engaged research (CER) is an evidence-based approach for successful URP recruitment, but has lacked scalability for broad implementation. Further, the lack of an ethnoculturally/linguistically diverse, culturally competent dementia workforce may further exacerbate these challenges. Thus, the 2019 update to the National Plan to Address AD and the NIA Advisory Council (NOT-AG-18-047) have recommended the prioritization of Health Disparities research in AD. ADNI4’s Engagement Core will address these urgent priorities through: 1) increasing the engagement of underrepresented populations in ADNI4; 2) cultivating a diverse, culturally competent workforce to work with URPs; and 3) investigating ethnocultural disparities in dementia. To this end, the Engagement Core will achieve these aims by deploying a scalable, intensive, and culturally-informed CER approach for ~20,000+ individuals (50-60% from URPs) to complete the digital screener to identify 4,000 participants with AD blood biomarkers, followed by either in-person (n = 500; 50-60% URPs) or remote (remainder of the 20,000 not enrolled in clinic) longitudinal evaluations. This Core will work closely with Project 1 and the other ADNI4 Cores to support their aims and assure the full and immersive participation of URPs in all study components. Our comprehensive, multi-faceted plan includes: (1) a CER-based Digital Engagement Campaign; (2) a Diverse Engagement Team, including Community Research Liaisons to promote URP recruitment through community-based engagement with local community-based organizations (CBOs), and Community Research Navigators to promote retention/engagement via providing navigational support to all participants and study partners; (3) Diversity Recruitment Hub Sites (n = 20) that will receive additional fiscal and instrumental support for URP recruitment; (4) Community Partnerships (e.g., national and local CBOs) that will be facilitated through our Community-Science Partnership Board; (5) Culturally-informed Methods to address barriers to URP recruitment/engagement (e.g., trust, burden) and provide better ethnocultural characterization of the sample; and (6) Workforce Training to enhance cultural competency of all ADNI investigators and staff, and provide mentored training to a total 15 ADNI4 Scholars over five years (URP trainees and early career investigators). The activities and goals detailed in this Core are deemed essential for the overarching success of ADNI-4 and have important implications for advancing recruitment science, informing clinical trials, addressing the urgent AD workforce shortage of culturally-competent researchers, and improving public health.

痴呆症差异是一项重大且迅速升级的公共卫生威胁。例如，黑人和拉丁裔成年人