Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys

从横断面血清调查中估计类鼻疽、伤寒和恙虫病的血清发病率

基本信息

  • 批准号:
    10706340
  • 负责人:
  • 金额:
    $ 18.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-21 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

SUMMARY/ABSTRACT This mentored International Research Scientist Development Award (K01) from UC Davis and Mahidol University-Thailand will support Dr. Kristen Aiemjoy, Assistant Professor of Epidemiology, to establish an impactful, independent global health research program developing seroepidemiologic tools to measure and reduce the burden on infectious diseases globally. In Thailand, a priority research need is scalable tools to understand the population-level burden for etiologies of acute fever, with acute undifferentiated fever being the second-leading cause of care-seeking nationwide. To meet this need, the scope of this K01 is to evaluate innovative and pragmatic seroepidemiologic tools to characterize the population-level burden of three etiologies of acute undifferentiated fever: scrub typhus, melioidosis, and typhoid fever. The Specific Aims are Aim 1A) To model longitudinal antibody responses for scrub typhus and melioidosis and estimate peak antibody response, decay rate, and decay shape, and Aim 1B) To determine if antibody responses vary according to age; Aim 2) To develop an analytic approach for estimating the seroincidence of scrub typhus, melioidosis and typhoid fever from cross-sectional survey data; and Aim 3) To quantify the magnitude of selection bias induced by a school- based sample relative to a random population-based sample when estimating the incidence of scrub typhus, melioidosis, and typhoid fever. Data sources for the research strategy include existing longitudinal data from confirmed melioidosis, scrub typhus, and typhoid fever cases; high-dimensional simulated data; and prospective population-level serosurveys in Nong Khai province in Northeast Thailand. The research aims are paired with training goals designed to provide Dr. Aiemjoy with the skills and experiences necessary to build an independent global health research program. The specific training goals are to 1) acquire technical proficiency in the fundamental immunology of scrub typhus, enteric fever, melioidosis infections relevant for seroepidemiology; 2) establish expertise in innovative analytic approaches and computation tools for serologic data; and 3) cultivate the leadership, professional skills, and research partnerships necessary to become an independent global health research scientist. The training plan will be guided by a team of experienced mentors led by Dr. Narisara Chantratita (primary co-mentor, Mahidol University), a globally recognized leader in melioidosis immunology with over 30 years of clinical and laboratory infectious disease research in Thailand. Dr. Jason Andrews (primary co- mentor, Stanford University), a clinical scientist with expertise in statistical inference and mathematical modeling, will provide mentorship to evaluate diagnostics and interventions for tropical infectious diseases. The prolonged field experience and collaborative research supported by this IRSDA-K01, coupled with strong institutional support from UC Davis (Dr. Pollock, UCD Chair of Public Health Sciences and professional development mentor), will cultivate a sustained international research partnership with Dr. Aiemjoy and Mahidol University aimed at reducing the burden of infectious disease in Thailand and Globally.
总结/摘要 这指导国际研究科学家发展奖(K 01)从加州大学戴维斯分校和玛希多 泰国大学将支持流行病学助理教授Kristen Aiemjoy博士建立一个 有影响力的独立全球卫生研究计划,开发血清流行病学工具, 减轻全球传染病的负担。在泰国,一个优先的研究需求是可扩展的工具, 了解急性发热病因的人口水平负担,急性未分化发热是 是全国第二大求医原因为了满足这一需求,本K 01的范围是评估 创新和实用的血清流行病学工具,以表征三种病因的人群水平负担 急性未分化热:恙虫病、类鼻疽病和伤寒。具体目标是:目标1A) 模拟恙虫病和类鼻疽病的纵向抗体应答并估计峰值抗体应答, 衰变率和衰变形状,以及目的1B)确定抗体应答是否随年龄而变化;目的2) 建立恙虫病、类鼻疽病和伤寒血清学发病率的分析方法 目的3)量化学校所引致的选择偏差的程度- 在估计恙虫病发病率时, 类鼻疽和伤寒研究策略的数据来源包括来自以下方面的现有纵向数据: 确诊的类鼻疽、恙虫病和伤寒病例;高维模拟数据;以及前瞻性 在泰国东北部的廊开府进行人口水平的血清调查。研究目标与 培训目标旨在为Aiemjoy博士提供必要的技能和经验, 全球健康研究计划。具体的培训目标是:1)掌握 与血清流行病学相关的恙虫病、肠热病、类鼻疽感染的基础免疫学; 2) 建立创新分析方法和血清学数据计算工具的专门知识; 3)培养 领导力,专业技能和研究伙伴关系,成为一个独立的全球卫生组织 研究科学家培训计划将由Narisara博士领导的经验丰富的导师团队指导 Chantratita(主要共同导师,玛希隆大学),全球公认的类鼻疽免疫学领导者, 在泰国从事了30多年的临床和实验室传染病研究。Jason Andrews博士(主要合作伙伴) 导师,斯坦福大学),临床科学家,具有统计推断和数学建模方面的专业知识, 将提供指导,以评估热带传染病的诊断和干预措施。长期 由IRSDA-K 01支持的现场经验和合作研究,加上强大的机构 来自加州大学戴维斯分校的支持(波洛克博士,公共卫生科学和专业发展的UCD主席 导师),将培养与艾姆乔伊博士和玛希隆大学持续的国际研究伙伴关系 旨在减少泰国和全球的传染病负担。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Estimating seroconversion rates accounting for repeated infections by approximate Bayesian computation.
通过近似贝叶斯计算估计重复感染的血清转化率。
  • DOI:
    10.1002/sim.9906
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Teunis,PeterFM;Wang,Yuke;Aiemjoy,Kristen;Kretzschmar,Mirjam;Aerts,Marc
  • 通讯作者:
    Aerts,Marc
Seroepidemiology for Enteric Fever: Emerging Approaches and Opportunities.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Kristen Aiemjoy其他文献

Kristen Aiemjoy的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Kristen Aiemjoy', 18)}}的其他基金

Serocalculator: Estimating Incidence Rates from Serological Data
血清计算器:根据血清学数据估算发病率
  • 批准号:
    10658478
  • 财政年份:
    2023
  • 资助金额:
    $ 18.03万
  • 项目类别:
Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys
从横断面血清调查中估计类鼻疽、伤寒和恙虫病的血清发病率
  • 批准号:
    10588900
  • 财政年份:
    2022
  • 资助金额:
    $ 18.03万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 18.03万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了