Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys

总结/摘要 这指导国际研究科学家发展奖（K01）从加州大学戴维斯分校和玛希多 泰国大学将支持流行病学助理教授Kristen Aiemjoy博士建立一个 有影响力的独立全球卫生研究计划，开发血清流行病学工具， 减轻全球传染病的负担。在泰国，一个优先的研究需求是可扩展的工具， 了解急性发热病因的人口水平负担，急性未分化发热是 是全国第二大求医原因为了满足这一需求，本K01的范围是评估 创新和实用的血清流行病学工具，以表征三种病因的人群水平负担 急性未分化热：恙虫病、类鼻疽病和伤寒。具体目标是：目标1A） 模拟恙虫病和类鼻疽病的纵向抗体应答并估计峰值抗体应答， 衰变率和衰变形状，以及目的1B）确定抗体应答是否随年龄而变化;目的2） 建立恙虫病、类鼻疽病和伤寒血清学发病率的分析方法 目的3）量化学校所引致的选择偏差的程度- 在估计恙虫病发病率时， 类鼻疽和伤寒研究策略的数据来源包括来自以下方面的现有纵向数据： 确诊的类鼻疽、恙虫病和伤寒病例;高维模拟数据;以及前瞻性 在泰国东北部的廊开府进行人口水平的血清调查。研究目标与 培训目标旨在为Aiemjoy博士提供必要的技能和经验， 全球健康研究计划。具体的培训目标是：1）掌握 与血清流行病学相关的恙虫病、肠热病、类鼻疽感染的基础免疫学; 2） 建立创新分析方法和血清学数据计算工具的专门知识; 3）培养 领导力，专业技能和研究伙伴关系，成为一个独立的全球卫生组织 研究科学家培训计划将由Narisara博士领导的经验丰富的导师团队指导 Chantratita（主要共同导师，玛希隆大学），全球公认的类鼻疽免疫学领导者， 在泰国从事了30多年的临床和实验室传染病研究。Jason Andrews博士（主要合作伙伴） 导师，斯坦福大学），临床科学家，具有统计推断和数学建模方面的专业知识， 将提供指导，以评估热带传染病的诊断和干预措施。长期 由IRSDA-K01支持的现场经验和合作研究，加上强大的机构 来自加州大学戴维斯分校的支持（波洛克博士，公共卫生科学和专业发展的ucd主席 导师），将培养与艾姆乔伊博士和玛希隆大学持续的国际研究伙伴关系 旨在减少泰国和全球的传染病负担。

SUMMARY/ABSTRACT This mentored International Research Scientist Development Award (K01) from UC Davis and Mahidol University-Thailand will support Dr. Kristen Aiemjoy, Assistant Professor of Epidemiology, to establish an impactful, independent global health research program developing seroepidemiologic tools to measure and reduce the burden on infectious diseases globally. In Thailand, a priority research need is scalable tools to understand the population-level burden for etiologies of acute fever, with acute undifferentiated fever being the second-leading cause of care-seeking nationwide. To meet this need, the scope of this K01 is to evaluate innovative and pragmatic seroepidemiologic tools to characterize the population-level burden of three etiologies of acute undifferentiated fever: scrub typhus, melioidosis, and typhoid fever. The Specific Aims are Aim 1A) To model longitudinal antibody responses for scrub typhus and melioidosis and estimate peak antibody response, decay rate, and decay shape, and Aim 1B) To determine if antibody responses vary according to age; Aim 2) To develop an analytic approach for estimating the seroincidence of scrub typhus, melioidosis and typhoid fever from cross-sectional survey data; and Aim 3) To quantify the magnitude of selection bias induced by a school- based sample relative to a random population-based sample when estimating the incidence of scrub typhus, melioidosis, and typhoid fever. Data sources for the research strategy include existing longitudinal data from confirmed melioidosis, scrub typhus, and typhoid fever cases; high-dimensional simulated data; and prospective population-level serosurveys in Nong Khai province in Northeast Thailand. The research aims are paired with training goals designed to provide Dr. Aiemjoy with the skills and experiences necessary to build an independent global health research program. The specific training goals are to 1) acquire technical proficiency in the fundamental immunology of scrub typhus, enteric fever, melioidosis infections relevant for seroepidemiology; 2) establish expertise in innovative analytic approaches and computation tools for serologic data; and 3) cultivate the leadership, professional skills, and research partnerships necessary to become an independent global health research scientist. The training plan will be guided by a team of experienced mentors led by Dr. Narisara Chantratita (primary co-mentor, Mahidol University), a globally recognized leader in melioidosis immunology with over 30 years of clinical and laboratory infectious disease research in Thailand. Dr. Jason Andrews (primary co- mentor, Stanford University), a clinical scientist with expertise in statistical inference and mathematical modeling, will provide mentorship to evaluate diagnostics and interventions for tropical infectious diseases. The prolonged field experience and collaborative research supported by this IRSDA-K01, coupled with strong institutional support from UC Davis (Dr. Pollock, UCD Chair of Public Health Sciences and professional development mentor), will cultivate a sustained international research partnership with Dr. Aiemjoy and Mahidol University aimed at reducing the burden of infectious disease in Thailand and Globally.