Investigating the Role of the Retrosplenial Cortex in Multi-step Planning

研究压后皮质在多步骤规划中的作用

基本信息

批准号：
10705643
负责人：
Rifqi Oklano Affan
金额：
$ 4.87万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10705643
关键词：
Academic Training Animals Award BRAIN initiative Behavior Behavioral Brain Brain region CCL7 gene Calcium Cognition Cognitive Computer Analysis Computer Models Data Decision Making Diagnosis Disease Distal Environment Evaluation Future Genetic Goals Head Human Image Impairment Intelligence Knowledge Label Learning Literature Measurement Memory Mental disorders Mentors Mentorship Methods Microscope Mission Modeling Monitor National Institute of General Medical Sciences Neurons Neurophysiology - biologic function Outcome Patients Pattern Performance Phase Population Postdoctoral Fellow Process Rat Transgene Rattus Research Research Personnel Research Project Grants Resolution Rewards Rodent Role Schizophrenia Techniques Technology Testing Therapeutic Intervention Training Translational Research United States National Institutes of Health Viral Work awake calcium indicator cell type experimental study flexibility genetic approach genetic manipulation innovation lens neural neural circuit neuroimaging neuromechanism neuropsychiatric disorder response skills tool

项目摘要

PROJECT SUMMARY/ABSTRACT Multi-step planning is a fundamental basis of human cognition and its impairment in disorders like schizophrenia disrupts goal-directed behavior in everyday situations. Essential to planning is the evaluation of alternative actions based on an internal model of the environment, but the exact neural implementation of this process is poorly understood. Several lines of evidence have implicated the retrosplenial cortex (RSC) in memory, prospection, and action evaluation, which makes the RSC the candidate region where model-based evaluation is most likely performed to support planning. However, the role of RSC in multi-step planning has never directly been tested. This project will address this gap by integrating cellular-resolution calcium imaging and chemogenetic perturbation to monitor and silence the activity of RSC neurons in rats performing a two-step task that elicits planning. By using this strategy, we will directly assess whether the activity of neurons in the RSC (1) encodes the model-based value of future actions and (2) causally contributes to planning behavior during the two-step task - two key evidence that can directly determine RSC’s role in multi-step planning. The identification of neuronal responses supporting multi-step planning will advance our basic understanding of the neurocomputational processes underlying cognition and inform direct translational research on the disruption of flexible behavior among psychiatric patients. The aims of this project resonate with the mission of the BRAIN Initiative in integrating innovative experimental and computational technologies to understand the neural mechanisms of multi-step planning and goal-directed behavior, with potentials for guiding the diagnosis and therapeutic intervention of related psychiatric disorders.

项目摘要/摘要多步规划是人类认知的基本基础及其在精神分裂症等疾病中的损害在每天情况下破坏目标指导的行为。计划的必不可少的是评估替代方案基于环境内部模型的行动，但是此过程的确切神经实施是理解不佳。几条证据已在记忆中实现了肾后皮质（RSC），降级和行动评估，这使RSC成为候选区域的基于模型的评估最有可能执行以支持计划。但是，RSC在多步规划中的作用从未直接直接经过测试。该项目将通过整合细胞分辨率钙成像和化学发生扰动以监测和沉默的大鼠RSC神经元的活性执行两步任务这引起了计划。通过使用此策略，我们将直接评估RSC中神经元的活性（1）。编码未来动作的基于模型的价值，以及（2）因果关系为计划行为做出贡献两步任务 - 两个可以直接确定RSC在多步计划中的作用的主要证据。标识支持多步规划的神经元反应将提高我们对认知基础的神经计算过程，并为中断的直接翻译研究提供了信息精神病患者的灵活行为。该项目的目的与大脑的使命共鸣整合创新的实验和计算技术以了解神经的主动性多步规划和目标指导行为的机制，具有指导诊断和的潜力相关精神疾病的治疗干预。