Investigating the Role of the Retrosplenial Cortex in Multi-step Planning

研究压后皮质在多步骤规划中的作用

• 批准号: 10610630
• 负责人: Rifqi Oklano Affan
• 金额: $ 4.78万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10610630
• 关键词: Academic Training; Address; Animals; Award; BRAIN initiative; Behavior; Behavioral; Brain; Brain region; CCL7 gene; Calcium; Cognition; Cognitive; Computer Analysis; Computer Models; Data; Decision Making; Diagnosis; Disease; Distal; Environment; Evaluation; Future; Genetic; Goals; Head; Human; Image; Impairment; Intelligence; Knowledge; Label; Learning; Literature; Measurement; Memory; Mental disorders; Mentors; Mentorship; Methods; Microscope; Mission; Modeling; Monitor; National Institute of General Medical Sciences; Neurons; Neurophysiology - biologic function; Outcome; Patients; Pattern; Performance; Phase; Play; Population; Process; Rattus; Research; Research Personnel; Research Project Grants; Resolution; Rewards; Rodent; Role; Schizophrenia; Techniques; Technology; Testing; Therapeutic Intervention; Training; Transgenic Organisms; Translational Research; United States National Institutes of Health; Viral; Work; awake; base; calcium indicator; cell type; experimental study; flexibility; innovation; lens; neural circuit; neuroimaging; neuromechanism; neuropsychiatric disorder; relating to nervous system; response; skills; tool

PROJECT SUMMARY/ABSTRACT Multi-step planning is a fundamental basis of human cognition and its impairment in disorders like schizophrenia disrupts goal-directed behavior in everyday situations. Essential to planning is the evaluation of alternative actions based on an internal model of the environment, but the exact neural implementation of this process is poorly understood. Several lines of evidence have implicated the retrosplenial cortex (RSC) in memory, prospection, and action evaluation, which makes the RSC the candidate region where model-based evaluation is most likely performed to support planning. However, the role of RSC in multi-step planning has never directly been tested. This project will address this gap by integrating cellular-resolution calcium imaging and chemogenetic perturbation to monitor and silence the activity of RSC neurons in rats performing a two-step task that elicits planning. By using this strategy, we will directly assess whether the activity of neurons in the RSC (1) encodes the model-based value of future actions and (2) causally contributes to planning behavior during the two-step task - two key evidence that can directly determine RSC’s role in multi-step planning. The identification of neuronal responses supporting multi-step planning will advance our basic understanding of the neurocomputational processes underlying cognition and inform direct translational research on the disruption of flexible behavior among psychiatric patients. The aims of this project resonate with the mission of the BRAIN Initiative in integrating innovative experimental and computational technologies to understand the neural mechanisms of multi-step planning and goal-directed behavior, with potentials for guiding the diagnosis and therapeutic intervention of related psychiatric disorders.

项目总结/文摘