Risk stratification strategies and abbreviated MRI-based surveillance for early detection of HCC in high-risk AI/AN patients
用于早期检测高危 AI/AN 患者 HCC 的风险分层策略和基于 MRI 的简化监测
基本信息
- 批准号:10706318
- 负责人:
- 金额:$ 20.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-06 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AbbreviationsAlaska NativeAmerican IndiansBiologicalCategoriesCessation of lifeCirrhosisColorectal CancerDevelopmentEarly DiagnosisEpidemiologyFaceFeasibility StudiesFoundationsFunctional disorderGeneticGenotypeHBV GenotypeHepatitis B InfectionHepatitis B VirusIncidenceMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of lungMalignant neoplasm of prostateMapsModelingMutationNative-BornPatientsPersonsPilot ProjectsPrimary carcinoma of the liver cellsProtocols documentationRandomized, Controlled TrialsReportingResearchRiskRisk FactorsRoleTestingUltrasonographyVeterans Health AdministrationWomancancer health disparityclinically significantcost effectivedisparity eliminationhigh riskimaging modalityimprovedindividual patientinnovationmachine learning algorithmmalignant breast neoplasmmenmortalitynovelpatient stratificationprospectiverisk stratificationscreeningsurveillance strategytranslational approach
项目摘要
ABSTRACT: PROJECT 2. Risk Stratification and abbreviated MRI-based surveillance
This translational project will first investigate further the clinical significance of an HCC pathogenetic mechanism
that we described, which is particularly important in AI/AN patients, i.e. HBV genotype-specific mutations. We
will then use AI/AN-specific HCC risk factors described by our group (including HBV genotype and genotype-
specific mutations) to develop AI/AN-specific “HCC Risk Calculators” for HCC risk stratification and risk-based
surveillance. Finally, we will use HCC Risk Calculators to identify high-risk patients for more intensive
surveillance strategies using abbreviated MRI, which will be tested in a pilot and feasibility RCT. The project will
accomplish the following specific aims:
SA1. Investigate the role of genotype-specific HBV mutations in the development of HCC in Alaska Native
patients: Determine the development of HBV genotype-specific mutations in AN patients with different HBV
genotypes prior to the occurrence of HCC compared to appropriate controls without HCC, and the excess HCC
risk associated with these mutations.
SA2. Develop and validate “HCC Risk Calculators” in AI/AN patients with HBV or cirrhosis using biological and
demographic predictors specific to AI/AN patients for the purpose of risk stratification, identification of high-risk
patients and personalized HCC surveillance strategies.
SA3. Perform a pilot and feasibility randomized controlled trial of abbreviated MRI (aMRI) versus
ultrasonography (US) for HCC screening in 200 AI/AN patients who have high HCC risk.
SIGNIFICANCE. This project will set the foundation for “precision HCC screening” based on estimating HCC
risk in individual patients using HCC Risk Calculators, risk stratifying patients according to their HCC risk, and
developing specific HCC surveillance strategies for different categories of HCC risk. This will be developed and
pursued further in a subsequent P50 application
摘要:项目2。风险分层和简化的基于MRI的监测
这个翻译项目将首先进一步研究肝癌发病机制的临床意义
这在AI/AN患者中特别重要,即HBV基因型特异性突变。我们
然后将使用我们小组描述的AI/AN特异性HCC风险因素(包括HBV基因型和基因型-
特定突变)开发AI/AN特异性“HCC风险计算器”,用于HCC风险分层和基于风险的
监视最后,我们将使用HCC风险计算器来识别高危患者,
使用简化MRI的监测策略,将在试点和可行性RCT中进行测试。该项目将
实现以下具体目标:
SA 1.研究基因型特异性HBV突变在阿拉斯加原住民HCC发生中的作用
患者:确定不同HBV感染的AN患者中HBV基因型特异性突变的发生情况
与没有HCC的适当对照相比,HCC发生前的基因型,
与这些突变相关的风险。
SA 2.使用生物学和生物学方法,在患有HBV或肝硬化的AI/AN患者中开发并验证“HCC风险计算器”,
特定于AI/AN患者的人口统计学预测因素,用于风险分层,识别高风险
患者和个性化HCC监测策略。
SA 3.对简化MRI(aMRI)与
在200例具有高HCC风险的AI/AN患者中进行超声(US)检查以进行HCC筛查。
意义该项目将为基于估计HCC的“精确HCC筛查”奠定基础
使用HCC风险计算器评估个体患者的风险,根据患者的HCC风险对患者进行风险分层,以及
针对不同类别的HCC风险制定具体的HCC监测策略。这将是发展和
在随后的P50申请中进一步追求
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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George Ioannou其他文献
George Ioannou的其他文献
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{{ truncateString('George Ioannou', 18)}}的其他基金
Risk stratification strategies and abbreviated MRI-based surveillance for early detection of HCC in high-risk AI/AN patients
用于早期检测高危 AI/AN 患者 HCC 的风险分层策略和基于 MRI 的简化监测
- 批准号:
10286760 - 财政年份:2021
- 资助金额:
$ 20.07万 - 项目类别:
Risk stratification strategies and abbreviated MRI-based surveillance for early detection of HCC in high-risk AI/AN patients
用于早期检测高危 AI/AN 患者 HCC 的风险分层策略和基于 MRI 的简化监测
- 批准号:
10482369 - 财政年份:2021
- 资助金额:
$ 20.07万 - 项目类别:
Development and Validation of a Cirrhosis-specific Surgical Risk Calculator (C-SuRC)
肝硬化特异性手术风险计算器 (C-SuRC) 的开发和验证
- 批准号:
10237196 - 财政年份:2020
- 资助金额:
$ 20.07万 - 项目类别:
Development and Validation of a Cirrhosis-specific Surgical Risk Calculator (C-SuRC)
肝硬化特异性手术风险计算器 (C-SuRC) 的开发和验证
- 批准号:
10652247 - 财政年份:2020
- 资助金额:
$ 20.07万 - 项目类别:
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