Developmental Research Program

摘要：开发和研究计划核心 美洲印第安人/阿拉斯加原住民肝癌发展研究计划 (DRP) (AI/AN) Disparities (Li-CAD) P20 计划将支持有潜力开辟新领域的早期项目 转化性肝癌研究最终有助于降低发病率和死亡率并改善 肝细胞癌 (HCC) 患者的生活质量。 DRP 资助的项目旨在 迅速提出一个新的想法或概念，有可能极大地影响我们对肝脏的理解 消除差异并改善 AI/AN 人群 HCC 的监测、早期发现和治疗 从而降低或消除 HCC 相关死亡率。 DRP的基础设施将建立机制 快速响应 Li-CAD P20 计划机构内需要的转化研究机会 支持提出假设或确认可行性，以证明更大的资源投资的合理性。 发展项目将包括基础科学、临床科学和基于人群的研究， 并将通过 P20 项目和 SPORE 在肝脏领域建立 Li-CAD 站点和其他机构之间的合作 癌症和差异研究。 开发项目可能涵盖广泛的肝癌研究和治疗领域，包括 基础科学、病因学和预防（初级和二级）、早期检测、预后、治疗和 生存。总的来说，DRP 的构建是为了加强 Li-CAD 站点之间的合作并启动 与其他机构在肝癌方面的 P20 计划和 SPORE 的互动。 DRP 提案将 根据他们将原创想法或概念成熟为转化研究项目的潜力而提供支持 将成功获得独立资金，无论是在随后的 P50 中还是从其他政府或 基础来源。此外，DRP 旨在吸引具有不同科学背景的高级研究人员 转化肝癌研究领域的专业知识和初级研究者。 发展研究计划的具体目标是： 1. 促进创新、有影响力的早期研究的发展，包括 与 Li-CAD 机构的基础科学家、临床科学家和人口科学家进行多学科互动； 2. 提供资金（1-2年）和基础设施（例如生物样本、生物统计支持）以快速测试 原研究者发起的项目在 HCC 研究所有领域的可行性； 3. 优先提供资金以快速利用新机遇或支持具有战略重要性的特定领域 推进 Li-CAD P20 计划的转化研究目标；和 4. 监控（并促进）每个 DRP 项目的进展，并考虑将其提升为完整的 P50 孢子项目。

ABSTRACT: DEVELOPMENTAL AND RESEARCH PROGRAM CORE The Developmental Research Program (DRP) of the Liver Cancer in American Indians/Alaska Natives (AI/AN) Disparities (Li-CAD) P20 Program will support early-phase projects that have the potential to open new areas of translational liver cancer research and ultimately, contribute to reducing morbidity and mortality and improving quality-of-life for patients with hepatocellular carcinoma (HCC). Projects funded under the DRP are intended to rapidly advance a new idea or concept that has the potential to substantially impact our understanding of liver cancer to eliminate disparities and improve surveillance, early detection, and treatment of HCC in AI/AN persons and thereby reduce or eliminate HCC-related mortality. The infrastructure of the DRP will establish mechanisms to quickly respond to translational research opportunities within the Li-CAD P20 Program institutions that require support to advance hypotheses or confirm feasibility in order to justify larger resource investments. Developmental projects will include research in basic science, clinical science, and population-based studies, and will build collaborations between Li-CAD sites and other institutions with P20 Programs and SPOREs in liver cancer and disparities research. Developmental projects may encompass a wide range of liver cancer research and treatment areas, including basic science, etiology and prevention (primary and secondary), early detection, prognosis, therapeutics, and survivorship. Collectively, the DRP is structured to strengthen collaborations between Li-CAD sites and initiate interactions with other institutions with P20 Programs and SPOREs in liver cancer. DRP proposals will be supported based on their potential to mature an original idea or concept into a translational research project that will successfully attain independent funding, either within a subsequent P50 or from other government or foundation sources. In addition, the DRP is designed to attract senior investigators with diverse scientific expertise and junior investigators new to translational liver cancer research. The Specific Aims for the Developmental Research Program are to: 1. Stimulate the development of innovative, impactful, early-phase research studies that include multidisciplinary interactions with basic, clinical, and population scientists across the Li-CAD institutions; 2. Provide funding (1-2 years) and infrastructure (e.g., biospecimens, biostatistical support) to rapidly test the feasibility of original investigator-initiated projects in all areas of HCC research; 3. Prioritize funding to rapidly exploit new opportunities or support specific areas of strategic importance for advancing the translational research goals of the Li-CAD P20 Program; and 4. Monitor (and facilitate) the progress of each DRP project and consider their advancement to a full P50 SPORE project.