Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico

艾滋病毒感染者预防 HPV 相关癌症的伙伴关系：巴西、墨西哥和波多黎各

• 批准号: 10706301
• 负责人: Anna R. Giuliano
• 金额: $ 155.37万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706301
• 关键词: Address; Brazil; Caribbean region; Cervical; Cervical Cancer Screening; Clinical; Clinical Trials; Collaborations; Conduct Clinical Trials; Country; DNA Methylation; Disease; Faculty; Future; Future Generations; Gender; Goals; HIV; HIV/AIDS; HPV oropharyngeal cancer; HPV-High Risk; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Individual; Institution; Intervention; Investigation; Knowledge; Latin America; Learning; Licensure; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methods; Methylation; Mexico; Morbidity - disease rate; Multi-Institutional Clinical Trial; Peer Review; Persons; Positioning Attribute; Prevention; Prospective, cohort study; Publications; Puerto Rico; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Priority; Site; Testing; Training; Training Programs; Triage; United States National Institutes of Health; Vaccination; Woman; cancer prevention; cervical cancer prevention; design; effective intervention; experience; high risk population; improved; innovation; malignant oropharynx neoplasm; men; mortality; novel; policy recommendation; prevent; preventive intervention; programs; screening program; therapeutic vaccine; vaccine trial

OVERALL ABSTRACT The Partnership Center, entitled Multinational Partnership to Prevent HPV-Associated Cancer in People Living with HIV: Brazil, Mexico, Puerto Rico (PHAC-BMPR), will bring together experienced research sites and world- renowned HPV and HIV researchers to build on established collaborations to conduct clinical trials on prevention of HPV-associated cancers among people living with HIV. This will provide an invaluable opportunity for newer investigators from Latin America/Caribbean (LAC) to participate in and learn from high- quality research. PHAC-BMPR will focus on two HPV-associated cancers that result in substantial morbidity and mortality: HPV- associated oropharyngeal cancer (HPV-OPC) and cervical cancer. These scientific goals are aligned with the goals of the US National Institutes of Health for research priorities for people living with HIV/AIDS as well as in country and regional goals to reduce cancer morbidity and mortality. At the end of this project, we hope to make advances that will highly impact prevention of HPV-associated cancers in people living with HIV and contribute to the global goal of cervical cancer elimination and reduction of other HPV-associated cancers such as oropharyngeal cancer (OPC).

总体摘要 合作中心，题为多国合作，以防止人类乳头状瘤病毒相关癌症的人生活 艾滋病毒：巴西，墨西哥，波多黎各（PHAC-BMPR），将汇集经验丰富的研究地点和世界， 著名的HPV和HIV研究人员建立在已建立的合作基础上， 预防艾滋病毒感染者中的HPV相关癌症。这将提供一个宝贵的 为拉丁美洲/加勒比地区的新研究人员提供机会，参加高级别的 质量研究。 PHAC-BMPR将重点关注两种导致大量发病率和死亡率的HPV相关癌症： 相关口咽癌（HPV-OPC）和宫颈癌。这些科学目标与 美国国立卫生研究院的目标，为艾滋病毒/艾滋病患者的研究重点，以及在 减少癌症发病率和死亡率的国家和区域目标。在这个项目结束时，我们希望 取得进展，这将对预防艾滋病毒感染者的HPV相关癌症产生重大影响， 有助于实现消除宫颈癌和减少其他HPV相关癌症的全球目标， 口咽癌（OPC）