Infection and Cancer Research: A New Frontier in Cancer Prevention and Control

描述（由申请人提供）：在过去的23年里，我在癌症感染研究方面积累了专业知识，并长期成功地获得了NIH的资助。在此期间，我成功地指导了许多研究生（n=41），博士后（n=11）和初级教师的职业生涯。我的职业生涯始于人类乳头瘤病毒（HPV）与女性宫颈癌之间的关系，后来发展到HPV与男性阴茎癌、肛门癌和口腔癌，以及其他传染病及其与各种癌症的因果关系。每年有近200万癌症病例归因于传染病，随着新的感染与癌症关联的阐明，预计这一数字还会增加。然而，许多感染可以用疫苗有效预防并用抗病毒疗法治疗，这为根除这些药物引起的癌症提供了独特的机会。因此，为了告知临床和公共卫生实践，这些因果关系的识别和特征构成了美国和世界范围内癌症预防和控制工作的当前和未来的优先事项。作为莫菲特癌症中心（Moffitt Cancer Center）癌症感染研究中心（CIRC）的创始主任，我的目标是促进跨学科研究工作，并招募有前途的新研究人员进入这一领域。该奖项提供的资金将为我提供受保护的时间，以实现指导和培训下一代科学家的目标，使他们积极参与感染和癌症之间的界面。Moffitt的Total Cancer Care （TCC）生物库，以及我的跨国男性HPV感染（HIM）研究队列的数据，将为流行病学、研究设计、生物统计学以及临床试验的设计、实施和监测等领域的培训和研究提供基础。使用TCC还将使我能够将研究扩展到多种病毒和肿瘤类型，例如血液恶性肿瘤。在该奖项的五年期间，预计将有12-15名学员参加。学员将被确定为那些对感染和癌症研究感兴趣的人，并将通过莫菲特建立的博士后和临床肿瘤学奖学金项目，莫菲特癌症流行病学和健康结果与行为部门以及南佛罗里达大学公共卫生和分子医学学院从各个学科招募。

DESCRIPTION (provided by applicant): Over the past 23 years, I have developed expertise in the study of infection research in cancer with a long and successful record of NIH funding. Throughout this time, I successfully mentored the careers of numerous graduate students (n=41), post-doctoral fellows (n=11), and junior faculty. My career had its inception in the relationship between human papillomavirus (HPV) and cervical cancer in women and has since evolved to encompass HPV and penile, anal, and oral cancers in men, as well as other infectious diseases and their causal relationships with various cancers. Nearly two million cancer cases are attributed to infectious diseases each year, a number that is expected to increase with the elucidation of new infection-cancer associations. However, many infections can be effectively prevented with vaccines and treated with antiviral therapeutics, providing a unique opportunity to eradicate cancers caused by these agents. Therefore, identification and characterization of these causal relationships in order to inform clinical and public health practice constitutes an immediate and future priority for cancer prevention and control efforts in the U.S. and worldwide. Through my new role as the founding Director for the Center for Infection Research in Cancer (CIRC) at the Moffitt Cancer Center, my goal is to foster transdisciplinary research efforts and recruit promising new investigators to this field. The funding provided by this award will provide me with protected time in which to pursue the goals of mentoring and training the next generation of scientists to become actively engaged at the interface between infection and cancer. Moffitt's Total Cancer Care (TCC) biorepository, as well as data from my multinational HPV Infection in Men (HIM) Study cohort, will provide the basis for training and research in the areas of epidemiology, study design, biostatistics, and the design, implementation, and monitoring of clinical trials. Use of the TCC will also enable me to expand research to multiple viruses and tumor types, such as hematological malignancies. A total of 12-15 mentees are expected to participate throughout the five-year period of the award. Mentees will be identified as those who have an interest in infection and cancer research and will be recruited from various disciplines through established Postdoctoral and Clinical Oncology Fellowship Programs at Moffitt, the departments of Cancer Epidemiology and Health Outcomes and Behavior at Moffitt, and the Colleges of Public Health and Molecular Medicine at the University of South Florida.