Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network

结核病区域前瞻性观察研究 (报告) – 巴西网络

• 批准号: 10535081
• 负责人: BRUNO DE BEZERRIL ANDRADE
• 金额: $ 100万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-02 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10535081
• 关键词: Acquired Immunodeficiency Syndrome; Area; Biological Assay; Biological Markers; Blood; Brazil; C-reactive protein; Caribbean region; Categories; Cellular Phone; Central America; Characteristics; China; Clinical; Clinical Data; Collaborations; Collection; Country; DNA; Data; Data Coordinating Center; Databases; Dedications; Demographic Factors; Diabetes Mellitus; Diagnosis; Diagnostic tests; Disease; Disease Notification; Drug resistance in tuberculosis; Drug resistant Mycobacteria Tuberculosis; Enrollment; Epidemiology; Ethambutol; Fellowship; Fluoroquinolones; Fostering; Foundations; Funding; Future; Genomics; Global Positioning System; Grant; Growth; HIV; HIV/TB; Hemoglobin; Immunology; Incidence; Incubators; India; Individual; Indonesia; Infection; Interferon Type II; International; Intervention; Molecular Epidemiology; Morbidity - disease rate; Mycobacterium tuberculosis; Observation in research; Outcome; Participant; Pathogenesis; Patients; Peripheral Blood Mononuclear Cell; Persons; Pharmaceutical Preparations; Pharmacogenomics; Phase; Philippines; Pilot Projects; Plasma; Population; Postdoctoral Fellow; Prediabetes syndrome; Predisposition; Prevention; Publications; Pulmonary Tuberculosis; Pyrazinamide; RNA; Registries; Research; Research Personnel; Resource-limited setting; Rifampicin resistance; Rifampin; Risk; Risk Factors; Role; Science; Scientific Advances and Accomplishments; Scientist; Sentinel; Site; South Africa; South America; Specimen; Sputum; Statistical Methods; System; Treatment outcome; Tuberculosis; Tuberculosis diagnosis; United States; Urine; Validation; Weight Gain; Whole Blood; Work; World Health Organization; biobank; career development; cohort; design; experience; fluoroquinolone resistance; follow-up; improved; inflammatory marker; insight; isoniazid; mortality; neutrophil; next generation; novel; novel diagnostics; outcome prediction; participant enrollment; point of care; predictive modeling; progression risk; prospective; transcriptomics; transmission process; tuberculosis diagnostics; tuberculosis treatment

PROJECT SUMMARY Brazil has the highest tuberculosis (TB) burden in the Western Hemisphere, and among the highest in the world. Advances in TB diagnosis, treatment, and prevention are necessary to improve the incidence, morbidity, and mortality of TB in Brazil, and globally. Regional Prospective Observational Research in TB (RePORT)- Brazil was initiated by our group in 2013, and enrolled 1,188 pulmonary TB patients and 1,930 of their close contacts in Phase 1. Clinical data and stored biorepository specimens have facilitated studies of predictors of TB and TB/HIV treatment outcomes, predictors of M. tuberculosis (Mtb) infection and progression to TB disease and incipient TB, TB-diabetes, drug-resistant TB, TB diagnostics, and Mtb transmission. Strong collaborations have been established with investigators in Brazil and the United States, as well as other RePORT networks (e.g., South Africa and India), the Caribbean Central America South America network for HIV epidemiology (CCASAnet) and its TB Sentinel Research Network (TB-SRN), which is part of the International epidemiologic Databases to Evaluate AIDS (IeDEA) network. In Phase 2 of RePORT-Brazil we will utilize the rich, high-quality clinical, genomic, and transcriptomic data generated in Phase 1, together with new participant enrollment, to extend our understanding of TB epidemiology and pathogenesis, and improve the diagnosis, treatment, and prevention of TB. This will be accomplished through three Specific Aims: 1) Gain insights that improve TB diagnosis, treatment, and outcomes. This will include external validation utilizing the TB case registry in Brazil (SINAN; the Brazilian National System of Diseases Notification), and other Brazilian registries as appropriate; 2) Improve our understanding of Mtb transmission and infection, including latent, incipient, and sub-clinical disease; predictors of progression to TB, and protection against TB; and 3) Support and develop the next generation of TB scientists, and enhance the scope and collaboration of RePORT-Brazil. For Aim 3, we will fund Fellowships in TB Science, focusing on Brazilian investigators. This will include two Early Career Development Fellowships per year, for pilot projects that support Brazil-US partnerships, and generate preliminary data for subsequent grant funding; and two Post-Doctoral Fellowships per year. Both categories of support will be for studies that utilize RePORT-Brazil data and/or specimens; proposals that also include data and specimens from other TB cohorts will be encouraged. The three Aims will facilitate further growth and strengthening of RePORT-Brazil, and generate insights that improve the diagnosis, treatment, and prevention of TB in Brazil.

项目摘要 巴西是西半球结核病负担最高的国家，也是世界上结核病负担最高的国家之一。 世界结核病诊断、治疗和预防方面的进展对于改善结核病的发病率、发病率， 以及全球结核病的死亡率。结核病区域前瞻性观察研究（报告）- 巴西由我们的小组于2013年发起，并招募了1，188名肺结核患者和1，930名密切相关的患者。 第一阶段的接触。临床数据和储存的生物储存库标本有助于研究 结核病和结核病/艾滋病治疗结果，M.结核病（Mtb）感染和进展为结核病 疾病和初期结核病、结核病糖尿病、耐药性结核病、结核病诊断和结核分枝杆菌传播。强 与巴西和美国的调查人员以及其他国家的调查人员建立了合作关系， 报告网络（例如，南非和印度）、加勒比、中美洲、南美洲 艾滋病毒流行病学（CCASAnet）及其结核病哨兵研究网络（TB-SRN），该网络是 国际流行病学数据库评估艾滋病（IeDEA）网络。在巴西报告的第二阶段， 将利用第一阶段产生的丰富、高质量的临床、基因组和转录组数据， 新的参与者登记，以扩大我们对结核病流行病学和发病机制的理解，并提高 结核病的诊断、治疗和预防。这将通过三个具体目标来实现：1）增益 提高结核病诊断、治疗和结果的见解。这将包括利用 巴西结核病例登记处（希南;巴西国家疾病通报系统），以及其他巴西 2）提高我们对结核病传播和感染的认识，包括潜伏性， 早期和亚临床疾病;结核病进展的预测因素和预防结核病;和3）支持 培养下一代结核病科学家，扩大巴西报告的范围和加强合作。 对于目标3，我们将资助结核病科学研究金，重点是巴西的研究人员。这将包括两个 每年为支持巴西-美国伙伴关系的试点项目提供早期职业发展奖学金，以及 为随后的赠款资金产生初步数据;和每年两个博士后奖学金。两 支持类别将用于使用报告-巴西数据和/或标本的研究;还 包括来自其他结核病群组数据和样本。这三个目标将进一步促进 增长和加强报告-巴西，并产生见解，改善诊断，治疗， 在巴西预防结核病。