Molecular Tools Core

分子工具核心

基本信息

项目摘要

Project Summary: Molecular Tools Core One of the major features of this BRAIN Initiative proposal on “Oxytocin Modulation of Neural Circuit Function and Behavior” is this Molecular Tools Research Support Core. Each of the Project teams is examining oxytocin release and the action of oxytocin receptor signaling. Oxytocin is exemplary among peptide hormones and neuromodulators, has been studied in various forms for over a century, and has clear physiological action, behavioral relevance, and biomedical importance. However, little is known about the cellular and network effects of oxytocin signaling. This is in part due to lack of specific antibodies for determining which brain areas and cell types express oxytocin receptors, as well as other molecular tools for specifically manipulating and monitoring oxytocin signaling with high spatiotemporal precision. Our labs have generated, validated, and are distributing the first specific antibodies to mouse oxytocin receptors, and have also developed the first successful versions of caged oxytocin compounds. Given the successful use and enthusiasm by the scientific community together with the need for continued validation and optimization, we feel obliged to scale-up production of these reagents and improve their functionality. There is clearly urgent and widespread need for these resources, which are best produced, tested, and distributed by a Core facility rather than by individual labs. Aim 1 of the Molecular Tools Core is to continue production of oxytocin receptor antibodies, distribute these antibodies broadly, and optimize their utility and specificity including generation of monoclonal antibodies. Aim 2 is to generate and optimize caged and photo-switchable forms of oxytocin receptor agonists and antagonists, useful for delineating specifically when and where oxytocin receptor signaling acts to generate physiological responses in the central nervous system and in peripheral tissues. Aim 3 generates reagents for click chemistry involving tagged oxytocin, to visualize oxytocin within fixed and live tissue, to help determine if and where exogenous oxytocin delivery acts within an organism. Aim 4 is to generate useful and when needed develop new mouse lines for cell-type specific dissection of oxytocinergic signaling, and to leverage transcriptome data and other gene expression resources to facilitate studies on the roles of molecularly defined Oxt+ and Oxtr+ populations in socio-spatial behavior.
项目概述:Molecular Tools Core

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MOSES VICTOR CHAO其他文献

MOSES VICTOR CHAO的其他文献

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{{ truncateString('MOSES VICTOR CHAO', 18)}}的其他基金

Attenuation of neuroinflammation and Alzheimer’s disease pathology by disrupting LXRα phosphorylation
通过破坏 LXRα 磷酸化来减轻神经炎症和阿尔茨海默病病理学
  • 批准号:
    10285124
  • 财政年份:
    2021
  • 资助金额:
    $ 68.5万
  • 项目类别:
Attenuation of neuroinflammation and Alzheimer’s disease pathology by disrupting LXRα phosphorylation
通过破坏 LXRα 磷酸化来减轻神经炎症和阿尔茨海默病病理学
  • 批准号:
    10460595
  • 财政年份:
    2021
  • 资助金额:
    $ 68.5万
  • 项目类别:
Targets of Oxytocin Receptor Signaling
催产素受体信号传导的靶点
  • 批准号:
    9901580
  • 财政年份:
    2019
  • 资助金额:
    $ 68.5万
  • 项目类别:
Targets of Oxytocin Receptor Signaling
催产素受体信号传导的靶标
  • 批准号:
    10569535
  • 财政年份:
    2019
  • 资助金额:
    $ 68.5万
  • 项目类别:
Targets of Oxytocin Receptor Signaling
催产素受体信号传导的靶标
  • 批准号:
    10348686
  • 财政年份:
    2019
  • 资助金额:
    $ 68.5万
  • 项目类别:
Diverse Neuroscientists: Doctoral Training Series (DeNDriTeS)
多元化的神经科学家:博士培训系列 (DeNDriTeS)
  • 批准号:
    10447210
  • 财政年份:
    2018
  • 资助金额:
    $ 68.5万
  • 项目类别:
Antibody Core
抗体核心
  • 批准号:
    10220154
  • 财政年份:
    2018
  • 资助金额:
    $ 68.5万
  • 项目类别:
Diverse Neuroscientists: Doctoral Training Series (DeNDriTeS)
多元化的神经科学家:博士培训系列 (DeNDriTeS)
  • 批准号:
    10199068
  • 财政年份:
    2018
  • 资助金额:
    $ 68.5万
  • 项目类别:
Antibody Core
抗体核心
  • 批准号:
    10438590
  • 财政年份:
    2018
  • 资助金额:
    $ 68.5万
  • 项目类别:
The role of neuroimmune interactions in the pathogenesis of chronic pain
神经免疫相互作用在慢性疼痛发病机制中的作用
  • 批准号:
    10451784
  • 财政年份:
    2018
  • 资助金额:
    $ 68.5万
  • 项目类别:

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职业:利用化学多样化的抗体发现下一代蛋白酶抑制剂
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    2024
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    Continuing Grant
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用于治疗或预防抗生素耐药鲍曼不动杆菌感染的单克隆抗体的分离和表征
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    MR/Y008693/1
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开发针对严重遗传神经系统疾病的一流聚集特异性抗体
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    23K14783
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