Translational Biomarkers Core

转化生物标志物核心

• 批准号: 10705787
• 负责人: Selena Ahmed
• 金额: $ 16.62万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10705787
• 关键词: Acceleration; Address; Alaska Native; Alcohol consumption; American Indians; Award; Behavior; Biological Markers; Biomedical Research; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Collection; Community Health; Consultations; Development; Diet; Drug usage; Ethics; Evaluation; Face; Faculty; Fees; Food; Funding; Future; Growth Factor; Health; Home; Hormones; Immunoassay; Inflammation; Institution; Intervention Trial; Life Style; Link; Liquid Chromatography; Measurement; Measures; Mentors; Metabolic Diseases; Methods; Mission; Modification; Montana; Observational Study; Oxidative Stress; Patient Self-Report; Performance; Phase; Pilot Projects; Protocols documentation; Reduce health disparities; Research; Research Personnel; Research Project Grants; Resources; Rural Community; Rural Population; Rural health equity; Scientist; Services; Socioeconomic Factors; Specimen Handling; Spectrophotometry; Students; Sustainable Development; Time; Training; Translational Research; Translations; Universities; Work; biomarker validation; community based participatory research; community based research; community center; health disparity; health equity; improved; innovation; instrument; instrumentation; interdisciplinary approach; medical schools; multidisciplinary; nephrotoxicity; prevent; programs; public health research; social; social health determinants; success; therapy development; translational goal; translational research program; underserved community

The overall goal of the Translational Biomarkers Core of the Center for American Indian and Rural Health Equity (CAIRHE) is to help COBRE-supported and other Montana State University (MSU) and regional investigators pursue multidisciplinary biomedical research by providing facilities, instrumentation, analytical services, and mentoring on biomarker assessments for diet, lifestyle, and chronic disease. Carrying out validated and culturally relevant biomedical research addressing social determinants of health is a critical research challenge in the Institutional Development Award (IDeA) state of Montana, which lacks a medical school and is home to Native and rural populations that face significant health disparities. In order to address this need, CAIRHE established the Translational Biomarkers Core during COBRE Phase I to strengthen the biomedical research capacity of its junior investigators and the capacity of other researchers to carry out translational interventions and clinical trials that address health equity. This includes investigators of the Montana IDeA Network for Biomedical Research Excellence (INBRE), the American Indian/Alaska Native Clinical and Translational Research Program (CTRP), and other programs. The Core will pursue the following three Specific Aims that leverage resources of CAIRHE and MSU. Aim 1: The Core will provide and maintain required state-of-the-art instrumentation in support of CAIRHE project leaders and other Center, INBRE, CTRP, and MSU investigators for use in validated biomarker analyses within health equity research projects. Major instruments maintained include a multiplex immunoassay analyzer, dual high- and ultra-performance liquid chromatography module, flow cytometer, spectrophotometer, fluorometer, and real-time PCR unit. Aim 2: The Core will provide lab analytical services to conduct validated biomarker assessments for CAIRHE investigators using Core instrumentation (as described in Aim 1) and protocols. These biomarker assessments will supplement observational and self-reported methods of CAIRHE investigators, providing a multidisciplinary approach that is innovative at MSU for examining social determinants of health. Assessments offered will focus on measurement of diet, lifestyle, and chronic disease biomarkers including inflammation, oxidative stress, hormones, metabolic disease, growth factors, kidney toxicity, and drug and alcohol use. Aim 3: The Core will provide guidance to Center faculty regarding its capabilities, including expertise and consultation on selection and/or modification of biomarker assessments, as well as training on use of instruments and analytical protocols. Ultimately, the Core will work toward the fulfillment of CAIRHE's mission to reduce significant health disparities in Native and rural communities while helping more junior investigators achieve independent status.

美国印第安人和农村健康中心转译生物标记物核心的总体目标 Equity(CAIRHE)是为了帮助科布雷支持的蒙大拿州立大学(MSU)和其他地区 研究人员通过提供设施、仪器设备、分析方法进行多学科生物医学研究 在饮食、生活方式和慢性病的生物标记物评估方面提供服务和指导。开展工作 解决健康的社会决定因素的经过验证的和与文化相关的生物医学研究是一个关键 蒙大拿州机构发展奖(IDEA)面临的研究挑战，该州缺乏医学 这是一所学校，是面临严重健康差距的土著和农村人口的家园。为了解决这个问题 出于这一需要，CAIRHE在科布雷第一阶段建立了翻译生物标记物核心，以加强 初级研究人员的生物医学研究能力和其他研究人员开展 涉及卫生公平的转化性干预和临床试验。这包括调查人员 美国印第安人/阿拉斯加原住民蒙大拿州卓越生物医学研究创意网络(INBRE) 临床和转化研究计划(CTRP)和其他计划。核心将追求以下目标 利用CAIRHE和MSU的资源的三个具体目标。目标1：核心将提供和维护 需要最先进的仪器设备来支持CAIRHE项目负责人和其他中心、INBRE、 CTRP和密歇根州立大学的调查人员，用于健康公平研究项目中经过验证的生物标记物分析。 维护的主要仪器包括一台多路免疫分析仪，双高性能和超高性能 液相色谱仪、流式细胞仪、分光光度计、荧光仪和实时聚合酶链式反应装置。目标2： 中心将提供实验室分析服务，为CAIRHE进行经过验证的生物标记物评估 使用核心仪器(如目标1所述)和协议的调查人员。这些生物标志物评估 将补充CAIRHE调查人员的观察和自我报告方法，提供多学科 这是密歇根州立大学在检查健康的社会决定因素方面的创新方法。提供的评估将集中于 测量饮食、生活方式和慢性病生物标记物，包括炎症、氧化应激、 激素、代谢性疾病、生长因子、肾脏毒性以及药物和酒精使用。目标3：核心意志 为中心教职员工提供能力方面的指导，包括专业知识和选拔咨询 和/或修改生物标记物评估，以及关于使用仪器和分析的培训 协议。最终，核心将致力于实现CAIRHE减少重大健康的使命 在帮助更多的初级调查人员获得独立地位的同时，解决土著社区和农村社区的差距问题。