Translational Biomarkers Core

转化生物标志物核心

• 批准号: 10254321
• 负责人: Selena Ahmed
• 金额: $ 15.75万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10254321
• 关键词: Address; Alaska Native; Alcohol consumption; American Indians; Award; Behavior; Biological Markers; Biomedical Research; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Collection; Community Health; Consultations; Development; Diet; Drug usage; Ethics; Evaluation; Face; Faculty; Fees; Food; Funding; Future; Goals; Growth Factor; Health; Home; Hormones; Immunoassay; Inflammation; Intervention; Intervention Trial; Life Style; Link; Liquid Chromatography; Measurement; Measures; Mentors; Metabolic Diseases; Methods; Mission; Modification; Montana; Observational Study; Oxidative Stress; Patient Self-Report; Performance; Phase; Pilot Projects; Protocols documentation; Research; Research Personnel; Research Project Grants; Resources; Rural Community; Rural Health; Rural Population; Scientist; Seeds; Services; Socioeconomic Factors; Specimen Handling; Spectrophotometry; Students; Sustainable Development; Time; Training; Translational Research; Translations; Universities; Work; base; community based participatory research; community based research; community center; health disparity; health equity; improved; innovation; instrument; instrumentation; interdisciplinary approach; lifestyle factors; medical schools; multidisciplinary; nephrotoxicity; prevent; programs; public health research; social; social health determinants; success; therapy development; translational research program; underserved community

The overall goal of the Translational Biomarkers Core of the Center for American Indian and Rural Health Equity (CAIRHE) is to help COBRE-supported and other Montana State University (MSU) and regional investigators pursue multidisciplinary biomedical research by providing facilities, instrumentation, analytical services, and mentoring on biomarker assessments for diet, lifestyle, and chronic disease. Carrying out validated and culturally relevant biomedical research addressing social determinants of health is a critical research challenge in the Institutional Development Award (IDeA) state of Montana, which lacks a medical school and is home to Native and rural populations that face significant health disparities. In order to address this need, CAIRHE established the Translational Biomarkers Core during COBRE Phase I to strengthen the biomedical research capacity of its junior investigators and the capacity of other researchers to carry out translational interventions and clinical trials that address health equity. This includes investigators of the Montana IDeA Network for Biomedical Research Excellence (INBRE), the American Indian/Alaska Native Clinical and Translational Research Program (CTRP), and other programs. The Core will pursue the following three Specific Aims that leverage resources of CAIRHE and MSU. Aim 1: The Core will provide and maintain required state-of-the-art instrumentation in support of CAIRHE project leaders and other Center, INBRE, CTRP, and MSU investigators for use in validated biomarker analyses within health equity research projects. Major instruments maintained include a multiplex immunoassay analyzer, dual high- and ultra-performance liquid chromatography module, flow cytometer, spectrophotometer, fluorometer, and real-time PCR unit. Aim 2: The Core will provide lab analytical services to conduct validated biomarker assessments for CAIRHE investigators using Core instrumentation (as described in Aim 1) and protocols. These biomarker assessments will supplement observational and self-reported methods of CAIRHE investigators, providing a multidisciplinary approach that is innovative at MSU for examining social determinants of health. Assessments offered will focus on measurement of diet, lifestyle, and chronic disease biomarkers including inflammation, oxidative stress, hormones, metabolic disease, growth factors, kidney toxicity, and drug and alcohol use. Aim 3: The Core will provide guidance to Center faculty regarding its capabilities, including expertise and consultation on selection and/or modification of biomarker assessments, as well as training on use of instruments and analytical protocols. Ultimately, the Core will work toward the fulfillment of CAIRHE's mission to reduce significant health disparities in Native and rural communities while helping more junior investigators achieve independent status.

美国印第安人和农村健康中心翻译生物标志物核心的总体目标 公平（CAIRHE）是为了帮助COBRE-supported和其他蒙大拿州立大学（MSU）和区域 研究人员通过提供设施、仪器、分析和信息， 服务，并指导饮食，生活方式和慢性疾病的生物标志物评估。进行 针对健康的社会决定因素进行有效和具有文化相关性的生物医学研究， 蒙大拿州的机构发展奖（IDEA）的研究挑战，缺乏医疗 学校是土著和农村人口的家园，面临着巨大的健康差距。为了解决 为了满足这一需求，CAIRHE在COBRE第一阶段建立了翻译生物标志物核心， 其初级研究人员的生物医学研究能力和其他研究人员开展生物医学研究的能力 转化干预措施和临床试验，解决健康公平问题。这包括调查人员的 蒙大拿州IDEA生物医学研究卓越网络（INBRE），美国印第安人/阿拉斯加原住民 临床和转化研究计划（CTRP）和其他计划。核心将致力于以下工作： 三个具体目标，利用CAIRHE和MSU的资源。目标1：核心将提供和维持 需要最先进的仪器，以支持CAIRHE项目负责人和其他中心，INBRE， CTRP和MSU研究者，用于健康公平研究项目中经验证的生物标志物分析。 维护的主要仪器包括一台多重免疫分析仪、一台高性能和超性能双功能 液相色谱模块、流式细胞仪、分光光度计、荧光计和实时PCR单元。目标二： 核心将提供实验室分析服务，以进行CAIRHE的经验证的生物标志物评估 研究者使用核心仪器（如目标1所述）和方案。这些生物标志物评估 将补充CAIRHE研究人员的观察和自我报告方法，提供多学科的 这是在MSU创新的方法来检查健康的社会决定因素。提供的评估将侧重于 测量饮食、生活方式和慢性疾病生物标志物，包括炎症，氧化应激， 激素、代谢性疾病、生长因子、肾毒性以及药物和酒精使用。目标3：核心将 为中心的教师提供有关其能力的指导，包括专业知识和选择咨询 和/或修改生物标志物评估，以及关于使用仪器和分析的培训。 协议.最终，核心将致力于实现CAIRHE的使命，以减少显著的健康 土著和农村社区的差异，同时帮助更多的初级调查人员获得独立地位。