The longitudinal relationship of sedentary behavior with health outcomes in a community-based cohort: The Johnston County Health Study

基于社区的队列中久坐行为与健康结果的纵向关系：约翰斯顿县健康研究

• 批准号: 10708395
• 负责人: Daniel K White
• 金额: $ 70.1万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708395
• 关键词: Address; Adult; Back Pain; Behavior; Chronic; Clinical; Clinical Trials; Cohort Studies; Communities; Computers; County; Data; Degenerative polyarthritis; Diabetes Mellitus; Equilibrium; Exercise; Extensor; Future; Gait speed; Guidelines; Hand Strength; Health; Hour; Infrastructure; Intervention; Intervention Studies; Isometric Exercise; Knee; Knee Osteoarthritis; Knowledge; Light; Muscle; Musculoskeletal; Musculoskeletal Diseases; Obesity; Outcome; Outcome Study; Pain; Physical Function; Physical activity; Questionnaires; Recommendation; Recording of previous events; Resources; Risk; Site; Supervision; Testing; Time; Walking; base; blind; chronic musculoskeletal pain; cohort; cost; design; effective intervention; epidemiology study; functional decline; health related quality of life; interest; monitoring device; mortality risk; osteoarthritis pain; pain score; sedentary lifestyle; stem; wasting

Project Summary/Abstract Adults with chronic musculoskeletal disease, such as knee osteoarthritis (OA) or back pain, are in urgent need of an effective intervention to reduce sedentary behaviors, such as excessive sitting. Historically, interventions have targeted physical activity via supervised exercise, but have largely ignored sedentary behaviors. Such sedentary behaviors impact health in ways that are independent of exercise, including increased risk of mortality, diabetes, and obesity. This is relevant to adults with chronic musculoskeletal disease who spend up to 3.5 hours/day more in sedentary behaviors than their healthy counterparts, and where intervention targeting sedentary behaviors has yet to be tested. However, before we can plan and implement a clinical trial, a critical gap in knowledge that must first be filled is how much sedentary behaviors need to be reduced to have clinically meaningful improvements in health. Surprisingly, there are no established standards to define excessive levels of sedentary behavior, nor recommendations for how much they should be reduced. Consequently, we are blind to what amount of sedentary behaviors should be targeted for change, and a clinical trial would be a waste of time and resources until we first establish this. To fill this gap, we propose to examine the relation of reduced sedentary behavior with clinically meaningful changes in pain, physical function, and Health Related Quality of Life (HRQoL) over 2 years in a large, diverse community-based cohort study currently in the field. The objective of this study is to use a state-of-the-art monitoring device, the activPAL, to evaluate sedentary behaviors within 1,500 adults from the Johnston County Health Study (JoCoHS). Our proposal will establish for the first time much-needed thresholds for targeting sedentary behaviors that will overcome current limitations in the field for designing and implementing effective clinical interventions that address excessive sedentary behaviors. We are specifically interested in understanding how sedentary behavior impacts common, yet costly, musculoskeletal outcomes such as pain, strength, physical function, and HRQoL. The results stemming from this proposal will provide essential data that is necessary for us to plan for a future clinical trial which would then broadly inform the wider scientific community of how to address sedentary behaviors in adults with chronic musculoskeletal disease.

项目总结/摘要 患有慢性肌肉骨骼疾病的成年人，如膝关节骨关节炎（OA）或背痛， 有效的干预措施，以减少久坐不动的行为，如过度坐。从历史上看， 有针对性的体育活动，通过监督锻炼，但在很大程度上忽略了久坐不动的行为。等 久坐不动的行为影响健康的方式是独立的运动，包括增加风险， 死亡率、糖尿病和肥胖症。这与患有慢性肌肉骨骼疾病的成年人有关， 久坐不动的行为比健康的同龄人多3.5小时/天， 久坐行为还有待测试。然而，在我们计划和实施临床试验之前， 首先必须填补的知识空白是，需要减少多少久坐行为， 有临床意义的健康改善。令人惊讶的是，没有既定的标准来定义 过度的久坐行为，也没有建议他们应该减少多少。 因此，我们对应该改变多少久坐不动的行为视而不见， 临床试验将是浪费时间和资源，直到我们首先建立这一点。为了填补这一空白，我们建议 检查久坐行为减少与疼痛、身体状况、 功能和健康相关生活质量（HRQoL）在一个大型的，多样化的社区队列中超过2年 目前在外地学习。本研究的目的是使用最先进的监测设备， activPAL，用于评估来自约翰斯顿县健康研究的1,500名成年人的久坐行为 （JoCoHS）.我们的提案将首次为久坐不动的人建立急需的阈值， 这些行为将克服该领域目前的局限性，以设计和实施有效的临床 解决过度久坐行为的干预措施。我们特别感兴趣的是 久坐行为会影响常见但代价高昂的肌肉骨骼结果，如疼痛、力量、身体 功能和HRQoL。这项建议产生的结果将提供必要的基本数据， 我们计划未来的临床试验，然后将广泛告知更广泛的科学界如何 解决患有慢性肌肉骨骼疾病的成年人的久坐行为。