Ultra-Fast Dose Rate (FLASH) Radiation Detector and Safety System

超快剂量率 (FLASH) 辐射探测器和安全系统

• 批准号: 10714550
• 负责人: RAYMOND BOISSEAU
• 金额: $ 39.79万
• 依托单位: PYRAMID TECHNICAL CONSULTANTS, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2023-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10714550
• 关键词: Animals; Clinical; Dependence; Development; Dose; Dose-Rate; Engineering; Environment; Feedback; Future; Goals; Investigation; Normal tissue morphology; Pattern; Phase; Polychlorinated Biphenyls; Protons; Radiation therapy; Reporting; Research; Safety; Scanning; Structure; Suggestion; System; Technology; Test Result; Testing; Time; To specify; Toxic effect; base; density; design; detector; dosimetry; interest; ionization; novel; proton beam; radiation detector

Animal studies show that external-beam radiotherapy reduces normal tissue toxicities when delivered at ultra-high dose rates (>40 Gy/s), a condition referred to as FLASH. The dependence of the FLASH effect on peak dose rate and beam time structure is under intense investigation. An enormous range of peak dose rates has been proposed, leading to research interest in a range of novel detector technologies that are not generally used in clinical dosimetry. We will concentrate on a specific, feasible configuration while still accommodating the full range of detectors under consideration.

动物研究表明，当以超高剂量率（>40戈伊/s）（一种称为FLASH的条件）进行外射束放射治疗时，可降低正常组织的毒性。FLASH效应对峰值剂量率和束流时间结构的依赖性正在深入研究中。已经提出了一个巨大的范围内的峰值剂量率，导致研究兴趣的范围内的新的探测器技术，通常不用于临床剂量测定。我们将集中于 一个具体的，可行的配置，同时仍然容纳所有的探测器正在考虑。