Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2

我们的目标是为有关COVID-19疫苗和增强剂的公共卫生指南提供信息，以减少免疫功能低下人群中的SARS-CoV-2感染和严重疾病。要做到这一点，需要具有临床信息的定义明确的人群的大型数据集和能够随着大流行期间出现的新研究问题而发展的强大协作基础设施。因此，我们建议模仿NA-ACCORD策略，在北美多个地点汇集队列。在这个汇集项目中，我们将合并来自以下两方面的数据：(i)电子病历（emr）以及（ii）来自美国11个地理分散的SeroNet站点的前瞻性队列数据。数据协调工作将被简化，分析将按所有站点的研究领域进行划分，以允许同时出现多个出版物。

Our goal is to inform public health guidelines on COVID-19 vaccine and boosters to reduce SARS-CoV-2 infection and severe illness in immunocompromised populations. To do so requires large datasets of well-defined populations with clinical information and a robust collaborative infrastructure able to evolve as new research questions arise during the pandemic. Therefore, we propose to mimic the NA-ACCORD strategy of pooling cohorts at multiple sites in North America. In this Pooling Project, we will merge data from both (i) electronic medical record (EMRs) as well as (ii) prospective cohorts from 11 geographically disperse SeroNet sites across the U.S. Data harmonization efforts will be streamlined, and analyses will be divided by research area across all sites to allow multiple publications to occur simultaneously.