Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2

SARS-CoV-2 免疫炎症反应的多样性和决定因素

• 批准号: 10706736
• 负责人: Jane C. Figueiredo
• 金额: $ 19.5万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706736
• 关键词: 2019-nCoV; Address; Affect; Area; Autoimmune Diseases; Basic Science; COVID-19; COVID-19 risk; COVID-19 susceptibility; COVID-19 treatment; California; Caring; Characteristics; Chronic Disease; Clinical; Clinical Sciences; Cohort Studies; Collaborations; Communities; Coronavirus; Data; Data Analyses; Data Collection; Disease; Enrollment; Ensure; Epidemiologist; Evaluation; Evaluation Studies; Exposure to; Foundations; Funding; Goals; Health; Health Personnel; Health system; Healthcare Systems; Home; Immune; Immunity; Immunologist; Individual; Infection; Inflammatory Response; Infrastructure; Institution; Knowledge; Los Angeles; Malignant Neoplasms; Metabolic Diseases; Minority; Molecular Profiling; Natural History; Nature; Outcome; Patients; Pattern; Persons; Population Heterogeneity; Population Sciences; Populations at Risk; Predisposition; Public Health; Publishing; Recovery; Recovery of Function; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Risk; SARS-CoV-2 antibody; SARS-CoV-2 exposure; Scientific Advances and Accomplishments; Scientist; Seeds; Seroprevalences; Signal Transduction; Structure; Subgroup; Techniques; Therapeutic; Translational Research; Viral; Virus; Vulnerable Populations; World Health Organization; base; biobank; clinical phenotype; disorder risk; experience; immune function; immune reconstitution; innate immune function; insight; novel; operation; pandemic disease; programs; racial and ethnic; recruit; response; severe COVID-19; trait; translational scientist

Our goal is to inform public health guidelines on COVID-19 vaccine and boosters to reduce SARS-CoV-2 infection and severe illness in immunocompromised populations. To do so requires large datasets of well-defined populations with clinical information and a robust collaborative infrastructure able to evolve as new research questions arise during the pandemic. Therefore, we propose to mimic the NA-ACCORD strategy of pooling cohorts at multiple sites in North America. In this Pooling Project, we will merge data from both (i) electronic medical record (EMRs) as well as (ii) prospective cohorts from 11 geographically disperse SeroNet sites across the U.S. Data harmonization efforts will be streamlined, and analyses will be divided by research area across all sites to allow multiple publications to occur simultaneously.

我们的目标是告知公众有关新冠肺炎疫苗和增强剂的公共卫生指南，以减少免疫低下人群中SARS-CoV-2的感染和严重疾病。要做到这一点，需要定义明确的人群的大型数据集，具有临床信息和强大的协作基础设施，能够随着大流行期间出现的新研究问题而发展。因此，我们建议模仿北美多个地点汇集队列的NA-ACCORD策略。在这个共享项目中，我们将合并来自(I)电子病历(EMR)以及(Ii)来自美国11个地理上分散的SeroNet站点的预期队列的数据。数据协调工作将得到简化，分析将根据所有站点的研究领域进行划分，以允许同时进行多个出版物。