NIAID DCR OPERATIONAL TASK ORDERCOVID FUNDING SUPPORTS THE NIAID DCR COVID WEBSITE AND THE VARIANT TESTING SAVE PROGRAM FOR VARIANT TESTING.

NIAID DCR 运营任务令 COVID 资金支持 NIAID DCR COVID 网站和用于变体测试的变体测试保存计划。

• 批准号: 10708257
• 负责人: BARRY GAUSE
• 金额: $ 120万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-31 至 2022-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708257
• 关键词: 2019-nCoV; Biological Assay; Blood Circulation; COVID-19 impact; COVID-19 testing; COVID-19 therapeutics; Clinical Research; Contracts; Diagnostic; Epidemiology; Evolution; Funding; Future; Genome; Hypersensitivity; Immune Evasion; Immune response; In Vitro; Infection; Institutes; Location; Monoclonal Antibodies; National Institute of Allergy and Infectious Disease; Observational Study; Public Health; Research Personnel; SARS-CoV-2 genome; SARS-CoV-2 variant; Sampling; Severity of illness; Specimen; Testing; Therapeutic; Variant; Viral; Virus; coronavirus disease; genetic variant; genome sequencing; targeted treatment; vaccine efficacy; web site; whole genome

COVID SARS-CoV-2 Assessment Viral Evolution (SAVE) variant testing provides support for analysis of SARS-CoV-2 genome sequences from specimens collected in COVID-19 therapeutic and observational trials for genetic variants that could impact diagnostics, therapeutics, vaccine efficacy, and disease severity. Additional genome sequencing will be done at NIAID Special Projects on samples collected from observational studies and for diagnostic purposes. This will broaden the understanding of the circulation of SARS-CoV-2 variants. COVID SAVE provides support for the analysis of the impact of SARS-CoV-2 variants in vitro neutralization assays. Additionally, COVID SAVE variant testing allows analysis of the evolution of SARS-CoV-2 and identification of future variants with potential public health impacts

COVID SARS-CoV-2评估病毒进化（SAVE）变异检测为分析从COVID-19治疗和观察试验中收集的标本中的SARS-CoV-2基因组序列提供支持，以确定可能影响诊断、治疗、疫苗有效性和疾病严重程度的遗传变异。另外的基因组测序将在NIAID特别项目中对从观察性研究中收集的样本进行，并用于诊断目的。这将扩大对SARS-CoV-2变异体传播的理解。COVID SAVE为SARS-CoV-2变异体在体外中和试验中的影响分析提供了支持。此外，COVID SAVE变体检测允许分析SARS-CoV-2的演变，并识别具有潜在公共卫生影响的未来变体