Support Mentoring of Early Career Clinical Researchers from Diverse Backgrounds

此应用程序响应RFA-DK-22012，支持早期职业指导的研究者奖 来自不同背景的研究人员为加拉格尔博士提供受保护的努力和资源， 建立NIDDK资助的调查员和导师，为研究生提供高质量的指导， 来自不同背景和代表性不足群体的博士后研究员。加拉格医生 经验指导研究员和初级教师，包括来自代表性不足的群体。她的领导作用 作为减重状态生理学（POWERS）研究中的MPI（5 UH 3DK 128302 -03：MPI Gallagher， Mayer，Leibel，Rosenbaum）提供了一个丰富的培训环境，并提供了各种各样的措施 和方法。众所周知，肥胖是人类疾病和卫生保健费用的主要贡献者。 适度的减肥可以减轻这些表型的严重程度-或完全逆转-许多。维护 一个人的身体减少7%，瘦和肥胖引起能量消耗的稳态变化 （减少）和饥饿（增加）倾向于恢复体重。我们假设， 反应，目前没有特点，占差异，在长期成功减少体重减轻 上维护POWERS将前瞻性地询问生理/行为系统， 体重减轻后体重变化的可变性。健康的肥胖成年人将被研究之前， 体重减轻后立即（第1阶段），以及在随访12个月期间观察第2阶段。参与者 将在18个月研究的4个时间点进行广泛的表型分析：体重、身体组成、总 能量消耗，能量摄入，静息能量消耗，体力活动，运动效率，睡眠 质量、食物选择、行为和心理社会评估。权力（在纽约营养肥胖 哥伦比亚研究中心）将作为框架，通过该框架，拟议的K24指导和 培训计划将被整合。指导目标1-研究：在权力研究框架内， 为受训者提供进行涉及先进国家的临床研究的接触和培训， 艺术方法，研究中的严谨性和再现性培训，人类受试者依从性，以及科学 手稿和赠款写作;指导目标2-职业发展：参加并在 地方和国家会议（例如，肥胖协会主办的肥胖周）;参加研讨会， 接触目前关于肥胖的方法学、生物学、心理学和营养学方面的研究， 与相关领域的专家建立联系，职业发展，指导如何有效地与 来自不同背景和学科的研究人员。作为导师，我的主要培训目标是培养技能 成为一个更具文化意识的导师，以最佳方式指导来自不同背景的早期职业调查人员。 具有增强的研究和领导能力，手稿和赠款写作经验，以及建立 导师网络，学员将很好地定位成长，并在他们的职业生涯取得成功。

This application responds to RFA-DK-22012, Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds to provide protected effort and resources to Dr. Gallagher, an established NIDDK-funded investigator and mentor to provide high quality mentoring to graduate students and postdoctoral fellows from diverse backgrounds and underrepresented groups. Dr. Gallagher has extensive experience mentoring fellows and junior faculty, including from underrepresented groups. Her leadership role as MPI in The Physiology of The Weight Reduced State (POWERS) study (5UH3DK128302-03: MPIs Gallagher, Mayer, Leibel, Rosenbaum) provides a rich environment for training with exposure to a diverse array of measures and methodologies. It is well known that obesity is a major contributor to human illness and health care costs. Modest weight loss can mitigate the severity – or entirely reverse - many of these phenotypes. Maintenance of a 7% reduced body in persons, lean and with obesity invokes homeostatic changes in energy expenditure (decreased) and hunger (increased) that tend to restore body weight. We hypothesize that the heterogeneity of response, currently not characterized, accounts for differences in long-term success for reduced weight loss maintenance. POWERS will prospectively interrogate the physiological/behavioral systems that contribute to variability in weight change following weight loss. Healthy adults with obesity will be studied before and immediately after weight loss (Phase 1), and during the follow-up 12 months observational Phase 2. Participants will be extensively phenotyped at 4 timepoints across the 18 months study: weight, body composition, total energy expenditure, energy intake, resting energy expenditure, physical activity, exercise efficiency, sleep quality, food choice, behavioral and psychosocial assessments. POWERS (within the New York Nutrition Obesity Research Center at Columbia) will serve as the framework through which the proposed K24 mentoring and training program will be integrated. Mentoring Aim 1-Research: within the framework of POWERS study, to provide the trainee with exposures and training in the conduct of clinical research involving advanced state-of- the art methods, training in rigor and reproducibility in research, human subject compliance, and scientific manuscript and grant writing; Mentoring Aim 2-Career Development: attend and give research presentations at local and national meeting (eg, ObesityWeek sponsored by The Obesity Society); attendance of seminars for exposure to current research on methodological, biological, psychological, and nutritional aspects of obesity, networking with experts in the related fields, career development, guidance on how to effectively collaborate with researchers from diverse backgrounds and disciplines. My primary training aim as a mentor is to develop skills to be a more culturally aware mentor to optimally mentor early career investigators from diverse backgrounds. With enhanced research and leadership skills, manuscript and grant writing experience, and an established mentoring network, trainees will be well positioned to grow and be successful in their careers..