Support Mentoring of Early Career Clinical Researchers from Diverse Backgrounds

支持来自不同背景的早期职业临床研究人员的指导

• 批准号: 10797859
• 负责人: DYMPNA GALLAGHER
• 金额: $ 8.42万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10797859
• 关键词: Academia; Adipose tissue; Advisory Committees; Advocate; Age; Award; Awareness; Basic Science; Behavior; Behavior assessment; Behavioral; Biological; Biology; Body Composition; Body Weight; Body Weight Changes; Body Weight decreased; Calendar; Cardiovascular Diseases; Career Mobility; Chronic Disease; Clinical; Clinical Investigator; Clinical Research; Collaborations; Complex; Cultural Diversity; Data Reporting; Development; Diabetes Mellitus; Discipline; Disease; Educational process of instructing; Energy Intake; Energy Metabolism; Ensure; Environment; Event; Exercise; Experimental Designs; Exposure to; Faculty; Food; Funding; General Population; Grant; Health; Health Care Costs; Heterogeneity; Homeostasis; Human; Human body; Hunger; Individual; Intervention; Knowledge; Leadership; Learning; Maintenance; Malignant Neoplasms; Manuscripts; Measurement; Measures; Mentors; Mentorship; Metabolic; Methodology; Methods; Molecular; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; New York; Nutritional; Obesity; Outcome; Paper; Participant; Pathway interactions; Persons; Phase; Phenotype; Physical activity; Physiological; Physiology; Positioning Attribute; Postdoctoral Fellow; Preparation; Procedures; Productivity; Psychosocial Assessment and Care; Regulation; Reproducibility; Research; Research Personnel; Resources; Rest; Role; Scientist; Services; Severities; Societies; System; Thinness; Time; Tissue Sample; Training; Training Programs; Translational Research; Travel; Underrepresented Populations; United States; Vocational Guidance; Weight; Work; Writing; adult obesity; career; career development; career networking; clinical development; clinical phenotype; cultural competence; design; evidence base; experience; follow-up; graduate student; human subject; leadership development; meetings; nutrition; participant enrollment; programs; prospective; psychologic; psychosocial; recidivism; research and development; research study; response; sex; skills; sleep quality; success; total energy expenditure

This application responds to RFA-DK-22012, Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds to provide protected effort and resources to Dr. Gallagher, an established NIDDK-funded investigator and mentor to provide high quality mentoring to graduate students and postdoctoral fellows from diverse backgrounds and underrepresented groups. Dr. Gallagher has extensive experience mentoring fellows and junior faculty, including from underrepresented groups. Her leadership role as MPI in The Physiology of The Weight Reduced State (POWERS) study (5UH3DK128302-03: MPIs Gallagher, Mayer, Leibel, Rosenbaum) provides a rich environment for training with exposure to a diverse array of measures and methodologies. It is well known that obesity is a major contributor to human illness and health care costs. Modest weight loss can mitigate the severity – or entirely reverse - many of these phenotypes. Maintenance of a 7% reduced body in persons, lean and with obesity invokes homeostatic changes in energy expenditure (decreased) and hunger (increased) that tend to restore body weight. We hypothesize that the heterogeneity of response, currently not characterized, accounts for differences in long-term success for reduced weight loss maintenance. POWERS will prospectively interrogate the physiological/behavioral systems that contribute to variability in weight change following weight loss. Healthy adults with obesity will be studied before and immediately after weight loss (Phase 1), and during the follow-up 12 months observational Phase 2. Participants will be extensively phenotyped at 4 timepoints across the 18 months study: weight, body composition, total energy expenditure, energy intake, resting energy expenditure, physical activity, exercise efficiency, sleep quality, food choice, behavioral and psychosocial assessments. POWERS (within the New York Nutrition Obesity Research Center at Columbia) will serve as the framework through which the proposed K24 mentoring and training program will be integrated. Mentoring Aim 1-Research: within the framework of POWERS study, to provide the trainee with exposures and training in the conduct of clinical research involving advanced state-of- the art methods, training in rigor and reproducibility in research, human subject compliance, and scientific manuscript and grant writing; Mentoring Aim 2-Career Development: attend and give research presentations at local and national meeting (eg, ObesityWeek sponsored by The Obesity Society); attendance of seminars for exposure to current research on methodological, biological, psychological, and nutritional aspects of obesity, networking with experts in the related fields, career development, guidance on how to effectively collaborate with researchers from diverse backgrounds and disciplines. My primary training aim as a mentor is to develop skills to be a more culturally aware mentor to optimally mentor early career investigators from diverse backgrounds. With enhanced research and leadership skills, manuscript and grant writing experience, and an established mentoring network, trainees will be well positioned to grow and be successful in their careers..

此应用程序响应 RFA-DK-22012，支持早期职业指导的研究者奖 来自不同背景的研究人员为加拉格尔博士提供受保护的努力和资源， 建立了NIDDK资助的研究员和导师，为研究生和研究生提供高质量的指导 来自不同背景和代表性不足群体的博士后研究员。加拉格尔博士拥有广泛的 拥有指导研究员和初级教师（包括来自代表性不足群体的人员）的经验。她的领导角色 作为体重减轻状态生理学 (POWERS) 研究中的 MPI（5UH3DK128302-03：MPIs Gallagher， Mayer、Leibel、Rosenbaum）提供了丰富的培训环境，可以接触到各种不同的措施 和方法论。众所周知，肥胖是导致人类疾病和医疗费用的主要原因。 适度的体重减轻可以减轻或完全逆转许多这些表型的严重程度。维护 瘦人和肥胖者的体重减少 7% 会引起能量消耗的稳态变化 （减少）和饥饿（增加）往往会恢复体重。我们假设异质性 目前尚未表征的反应，解释了减轻体重减轻的长期成功的差异 维护。 POWERS 将前瞻性地询问有助于的生理/行为系统 体重减轻后体重变化的变异性。将在之前和之后对患有肥胖症的健康成年人进行研究 减肥后立即进行（第一阶段），以及在后续 12 个月的观察阶段 2 期间。参与者 将在 18 个月研究的 4 个时间点进行广泛的表型分析：体重、身体成分、总体 能量消耗、能量摄入、静息能量消耗、体力活动、运动效率、睡眠 质量、食物选择、行为和社会心理评估。 POWERS（纽约营养肥胖 哥伦比亚研究中心）将作为框架，通过该框架拟议的 K24 指导和 培训计划将被整合。指导目标 1-研究：在 POWERS 研究框架内， 为学员提供进行涉及先进状态的临床研究的接触和培训 艺术方法、研究严谨性和可重复性的培训、人类受试者的依从性和科学性 手稿和资助写作；指导目标 2 - 职业发展：参加并发表研究报告 地方和国家会议（例如，肥胖协会主办的肥胖周）；出席研讨会 了解肥胖的方法学、生物学、心理和营养方面的最新研究， 与相关领域的专家建立联系、职业发展、如何有效合作的指导 来自不同背景和学科的研究人员。作为导师，我的主要培训目标是培养技能 成为一名更具文化意识的导师，以最佳方式指导来自不同背景的早期职业调查员。 凭借增强的研究和领导技能、手稿和拨款写作经验以及成熟的 导师网络，学员将处于有利地位，能够成长并在职业生涯中取得成功。