Administrative supplement for the purchase of a confocal microscope
购买共聚焦显微镜的行政补充
基本信息
- 批准号:10797113
- 负责人:
- 金额:$ 25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-10 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:Administrative SupplementAffectAgingBiochemicalCardiovascular PathologyCell DeathCell SurvivalCellsComputer SimulationCuesDevelopmentDiseaseDisease ProgressionEnvironmentEventExposure toGoalsInvadedMalignant NeoplasmsMicroscopeMolecularNeoplasm MetastasisPhysiologicalPlayPostdoctoral FellowRegulationRoleSignal TransductionWorkcell behaviorcell motilityexperiencein vivointerdisciplinary approachinterstitialmechanical signalmicrodevicemigrationnew therapeutic targetnovelnovel therapeutic interventionnovel therapeuticsoptogeneticsorgan growthpressurepreventshear stressstem cell therapytissue regenerationtooltranscriptomicsviscoelasticitywound healing
项目摘要
Contact PD/PI: Mistriotis, Panagiotis
Summary: Cell migration is a fundamental cellular phenomenon that plays a pivotal role in (patho)physiological
events, including organ development, tissue regeneration and cancer metastasis. Our long-term goal is to
achieve a comprehensive understanding of the mechanisms of cell migration in order to develop novel
therapeutic tools and strategies to prevent the initiation and progression of diseases, including cardiovascular
pathologies, aging, and cancer. Building on the PI's postdoctoral work, the lab explores how the physical cues
of the local microenvironment (e.g., confinement, viscoelasticity, stiffness, pressure and shear stress) convert
into biochemical signals to influence the migratory behavior of cells. Over the next five years, we will employ
state-of-the-art microfabricated devices, materials, optogenetic tools, single-cell transcriptomics and
computational simulations to elucidate the effects of pressure forces on cell migration and viability. The scientific
premise of this application is based on prior studies showing that cells experience elevated pressure forces
during various stages of migration and invasion, including extra/intravasation and interstitial migration. Although
the widely held view is that cells can adapt to mechanical cues, an open and unaddressed question is how
elevated pressure affects cell behavior in diverse, yet physiologically relevant, microenvironments. To answer
this question, we will investigate the interplay between pressure forces and different microenvironmental cues
(physical or biochemical) in the regulation of cell migration. We will also assess whether long-term cell exposure
to high pressures alters the sensitivity of cell motility to physical cues. Last but not least, we will dissect the
relative roles and potential crosstalk between confinement and pressure in cell death regulation. Taken together,
the proposed studies, which are supported by highly encouraging preliminary results, will delineate the
underlying mechanisms regulating cell behavior in physiological environments and generate novel conceptual
information that will facilitate the identification of new therapeutic targets aimed at promoting or preventing cell
motility in vivo.
Project Summary/Abstract Page 6
联系PD/PI:三角炎,panagio炎
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement.
- DOI:10.1002/advs.202302228
- 发表时间:2023-08
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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Panagiotis Mistriotis其他文献
Panagiotis Mistriotis的其他文献
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{{ truncateString('Panagiotis Mistriotis', 18)}}的其他基金
Cell mechanoresponses in physiologically relevant microenvironments
生理相关微环境中的细胞机械反应
- 批准号:
10676193 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
Cell mechanoresponses in physiologically relevant microenvironments
生理相关微环境中的细胞机械反应
- 批准号:
10500944 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
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