Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products - Equipment Supplement

请求摘要。我们正在申请资金购买一台微波合成器， Biotage Initiator+与机器人八，使复杂有机化合物的精确和高效合成成为可能 分子。微波合成是一种成熟的化学合成方法，尤其是 对于需要高温的反应，由于其能够提供更高的产率，更少的副产物， 以及更短的反应时间。该反应器将使我们能够进行复杂的有机合成 从安全的微波源发出强烈、均匀的热量的受控条件。此外，自动取样器 该附件将有助于反应条件的优化和探索更广泛的 反应底物。总体而言，反应堆将大大增强我们完成所述工作的能力 在我们的资助中，《用于简单合成复杂吲哚生物碱的新方法和策略》(NIH- NIGMS 5R01GM144663-02)。

Summary of the Request. We are requesting funds for the purchase of a microwave synthesizer, the Biotage Initiator+ with Robot Eight, to enable the precise and efficient synthesis of complex organic molecules. Microwave-based synthesis represents an established method for chemical synthesis, especially for reactions that require high temperatures, due to its ability to provide higher yields, fewer side products, and shorter reaction times. This reactor will enable us to perform complex organic syntheses under controlled conditions of intense, even heat from a safe microwave source. Additionally, the auto-sampler accessory will facilitate the optimization of reaction conditions and the exploration of a wider range of reaction substrates. Overall, the reactor will significantly enhance our ability to complete the work outlined in our grant, “New Methods and Strategies for the Concise Synthesis of Complex Indole Alkaloids” (NIH- NIGMS 5R01GM144663-02).