Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products - Equipment Supplement

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Summary of the Request. We are requesting funds for the purchase of a microwave synthesizer, the Biotage Initiator+ with Robot Eight, to enable the precise and efficient synthesis of complex organic molecules. Microwave-based synthesis represents an established method for chemical synthesis, especially for reactions that require high temperatures, due to its ability to provide higher yields, fewer side products, and shorter reaction times. This reactor will enable us to perform complex organic syntheses under controlled conditions of intense, even heat from a safe microwave source. Additionally, the auto-sampler accessory will facilitate the optimization of reaction conditions and the exploration of a wider range of reaction substrates. Overall, the reactor will significantly enhance our ability to complete the work outlined in our grant, “New Methods and Strategies for the Concise Synthesis of Complex Indole Alkaloids” (NIH- NIGMS 5R01GM144663-02).