Encoding of inflammatory mediators by vagal sensory neurons

迷走神经感觉神经元编码炎症介质

基本信息

项目摘要

Project Summary The nervous system and immune system communicate with each other to respond to infections and maintain immune homeostasis. Work over the last two decades has shown that the vagus nerve is a critical pathway for neuro-immune communication carrying motor signals descending to the body, in addition to sensory signals ascending to the brain. Detection of immune mediators in the periphery, such as cytokines, is thought to be vagally-mediated but it is unclear how sensory neurons respond and represent this information in situ. The goal of the proposed studies is to discover how vagal sensory neurons encode and represent information about specific inflammatory mediators. This new understanding will provide crucial mechanistic insights into the nervous system representation of immune signals, which can be used to understand what goes wrong in a host of inflammatory disorders that involve immune dysregulation. With a team of experienced scientists who are experts in the neural regulation of immunity, we will use genetically encoded calcium indicators to monitor large groups of vagal sensory neurons while they respond to specific inflammatory mediators. We will use techniques and tools adopted from neuroscience to determine whether these neurons encode information using a population code or a temporal code for representing information immune-relevant information.
项目总结

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Fifth Bioelectronic Medicine Summit: today's tools, tomorrow's therapies.
  • DOI:
    10.1186/s42234-023-00123-4
  • 发表时间:
    2023-10-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Chang, Eric H;Gabalski, Arielle H;Huerta, Tomas S;Datta-Chaudhuri, Timir;Zanos, Theodoros P;Zanos, Stavros;Grill, Warren M;Tracey, Kevin J;Al-Abed, Yousef
  • 通讯作者:
    Al-Abed, Yousef
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Eric Hau-Yun Chang其他文献

Eric Hau-Yun Chang的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Eric Hau-Yun Chang', 18)}}的其他基金

Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
  • 批准号:
    10649708
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
  • 批准号:
    10455567
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
  • 批准号:
    10280081
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:

相似海外基金

How Spinal Afferent Neurons Control Appetite and Thirst
脊髓传入神经元如何控制食欲和口渴
  • 批准号:
    DP220100070
  • 财政年份:
    2023
  • 资助金额:
    $ 9.06万
  • 项目类别:
    Discovery Projects
The mechanisms of the signal transduction from brown adipocytes to afferent neurons and its significance.
棕色脂肪细胞向传入神经元的信号转导机制及其意义。
  • 批准号:
    23K05594
  • 财政年份:
    2023
  • 资助金额:
    $ 9.06万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Neurobiology of Intrinsic Primary Afferent Neurons
内在初级传入神经元的神经生物学
  • 批准号:
    10477437
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
GPR35 on Vagal Afferent Neurons as a Peripheral Drug Target for Treating Diet-Induced Obesity
迷走神经传入神经元上的 GPR35 作为治疗饮食引起的肥胖的外周药物靶点
  • 批准号:
    10315571
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Neurobiology of Intrinsic Primary Afferent Neurons
内在初级传入神经元的神经生物学
  • 批准号:
    10680037
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Neurobiology of Intrinsic Primary Afferent Neurons
内在初级传入神经元的神经生物学
  • 批准号:
    10654779
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Neurobiology of Intrinsic Primary Afferent Neurons
内在初级传入神经元的神经生物学
  • 批准号:
    10275133
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
GPR35 on Vagal Afferent Neurons as a Peripheral Drug Target for Treating Diet-Induced Obesity
迷走神经传入神经元上的 GPR35 作为治疗饮食引起的肥胖的外周药物靶点
  • 批准号:
    10470747
  • 财政年份:
    2021
  • 资助金额:
    $ 9.06万
  • 项目类别:
Roles of mechanosensory ion channels in myenteric intrinsic primary afferent neurons
机械感觉离子通道在肌间固有初级传入神经元中的作用
  • 批准号:
    RGPIN-2014-05517
  • 财政年份:
    2018
  • 资助金额:
    $ 9.06万
  • 项目类别:
    Discovery Grants Program - Individual
Roles of mechanosensory ion channels in myenteric intrinsic primary afferent neurons
机械感觉离子通道在肌间固有初级传入神经元中的作用
  • 批准号:
    RGPIN-2014-05517
  • 财政年份:
    2017
  • 资助金额:
    $ 9.06万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了