Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
基本信息
- 批准号:10797388
- 负责人:
- 金额:$ 9.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdoptedAfferent NeuronsBiological Response ModifiersBrainCodeCommunicationCritical PathwaysDetectionDiseaseGoalsHomeostasisImmuneImmune signalingImmune systemImmunityIn SituInfectionInflammation MediatorsInflammatoryMediatingMediatorMethodsMonitorMotorNervous SystemNeuroimmuneNeuronsNeurosciencesPeripheral Nervous SystemPopulationScientistSensorySignal TransductionTechniquesVagus nerve structureWorkcalcium indicatorcytokineexperienceinsightneuralneuroregulationnoveltool
项目摘要
Project Summary
The nervous system and immune system communicate with each other to respond to infections
and maintain immune homeostasis. Work over the last two decades has shown that the vagus
nerve is a critical pathway for neuro-immune communication carrying motor signals descending
to the body, in addition to sensory signals ascending to the brain. Detection of immune mediators
in the periphery, such as cytokines, is thought to be vagally-mediated but it is unclear how sensory
neurons respond and represent this information in situ. The goal of the proposed studies is to
discover how vagal sensory neurons encode and represent information about specific
inflammatory mediators. This new understanding will provide crucial mechanistic insights into the
nervous system representation of immune signals, which can be used to understand what goes
wrong in a host of inflammatory disorders that involve immune dysregulation.
With a team of experienced scientists who are experts in the neural regulation of immunity, we
will use genetically encoded calcium indicators to monitor large groups of vagal sensory neurons
while they respond to specific inflammatory mediators. We will use techniques and tools adopted
from neuroscience to determine whether these neurons encode information using a population
code or a temporal code for representing information immune-relevant information.
项目总结
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Fifth Bioelectronic Medicine Summit: today's tools, tomorrow's therapies.
- DOI:10.1186/s42234-023-00123-4
- 发表时间:2023-10-05
- 期刊:
- 影响因子:0
- 作者:Chang, Eric H;Gabalski, Arielle H;Huerta, Tomas S;Datta-Chaudhuri, Timir;Zanos, Theodoros P;Zanos, Stavros;Grill, Warren M;Tracey, Kevin J;Al-Abed, Yousef
- 通讯作者:Al-Abed, Yousef
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Eric Hau-Yun Chang其他文献
Eric Hau-Yun Chang的其他文献
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{{ truncateString('Eric Hau-Yun Chang', 18)}}的其他基金
Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
- 批准号:
10649708 - 财政年份:2021
- 资助金额:
$ 9.06万 - 项目类别:
Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
- 批准号:
10455567 - 财政年份:2021
- 资助金额:
$ 9.06万 - 项目类别:
Encoding of inflammatory mediators by vagal sensory neurons
迷走神经感觉神经元编码炎症介质
- 批准号:
10280081 - 财政年份:2021
- 资助金额:
$ 9.06万 - 项目类别:
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