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Solvation modeling for next-gen biomolecule simulations

Solvation modeling for next-gen biomolecule simulations
下一代生物分子模拟的溶剂化建模
批准号：
10798773
负责人：
Ken A Dill
金额：
$20.4万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
未结题
起止时间：
2020-06-01 至 2025-05-31
来源：
https://reporter.nih.gov/project-details/10798773
关键词：
AffinityAntibodiesBindingBiosensorExcipientsImmobilizationInterferometryKineticsLabelLigand BindingLigandsLightModelingMonitorOpticsPatternPricePropertyProteinsSurfaceTaxesTechniquesThickTimenew technologysimulation

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中文摘要
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英文摘要
Apparatus ForteBio/Sartorius OCTET R2 for biolayer interferometry. Bio-Layer Interferometry is an analytical technique that monitors the interference pattern of white light reflected from two surfaces; a layer of immobilized protein on the biosensor tip and an internal reference layer. The binding of an analyte in solution to the immobilized protein (ligand) on the biosensor results in an increase in optical thickness which in turn causes a shift in the interference pattern resulting in a wavelength shift. From this wavelength shift the apparatus enables real-time determination of kinetics, protein-ligand affinity and antibody/protein quantitation without the need for fluorescent labeling. Approximate price including taxes is 204,000 USD.
期刊论文(33)
专著(0)
科研奖励(0)
会议论文
Influence of Low Molecular Weight Salts on the Viscosity of Aqueous-Buffer Bovine Serum Albumin Solutions.
DOI： 10.3390/molecules27030999
发表时间： 2022-02-01
期刊： Molecules (Basel, Switzerland)
影响因子： --
作者： [Zdovc B, Jaklin M, Hribar-Lee B, Lukšič M]
通讯作者： Lukšič M
Structure and thermodynamics of a 2D Lennard-Jones hexagonal fluid.
DOI： 10.1080/08927022.2022.2096219
发表时间： 2022
期刊： Molecular simulation
影响因子： 2.1
作者： []
通讯作者：
A new fibrillization mechanism of β-lactoglobulin in glycine solutions.
DOI： 10.1016/j.ijbiomac.2022.06.182
发表时间： 2022-09-01
期刊： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
影响因子： 8.2
作者： [Jaklin, Matej, Hritz, Jozef, Hribar-Lee, Barbara]
通讯作者： Hribar-Lee, Barbara
Effect of Buffer on Protein Stability in Aqueous Solutions: A Simple Protein Aggregation Model.
DOI： 10.1021/acs.jpcb.0c10339
发表时间： 2021-03-18
期刊： The journal of physical chemistry. B
影响因子： --
作者： [Brudar S, Hribar-Lee B]
通讯作者： Hribar-Lee B
共 28 条
    PARAMETER Optimization and Protein Folding Simulation
    PROTEIN FOLDING PATHWAYS FROM PARALLEL TEMPERING SIMULATIONS: HYDROPHOBIC ZIPPI
    Protein Folding Pathways from Parallel Tempering Simulations: Hydrophobic Zippi
    Modeling Aqueous Solvation in Biology
    海外基金