Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

在交叉偶联中利用烷基胺和烷基醇的行政补充

• 批准号: 10798396
• 负责人: Mary P Watson
• 金额: $ 8.61万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10798396
• 关键词: 14 year old; 3-Dimensional; Administrative Supplement; Alcohols; Amines; Awareness; Biological; Coupling; Deterioration; Development; Goals; High Pressure Liquid Chromatography; Liquid substance; Medicine; Methods; Parents; Performance; Public Health; Research; Research Support; drug development; enantiomer; human disease; instrument; programs

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.

摘要 本R35 GM131816的补充旨在购买Shimadzu Nexera™超高 高效液相色谱法（UHPLC）用于有机化合物对映体过量的高效测定 化合物.由于对映异构体的生物活性不同，需要有效的方法来 制备高对映体纯度的生物活性分子。认识到这一重要需求， 制备高度对映体富集的有机化合物的新方法是母公司研究的一个主要焦点 程序.拟议的UHPLC仪器将取代迅速恶化的14岁的HPLC， 是一个关键的主力工具，使R35支持的研究。

项目成果

Stitching two chiral centers with one catalyst.

用一种催化剂缝合两个手性中心。

• DOI: 10.1126/science.aba4222
• 发表时间: 2020
• 期刊: Science (New York, N.Y.)
• 作者: Xu,Jianyu;Watson,MaryP
• 通讯作者: Watson,MaryP

Nickel-Catalyzed, Stereospecific C-C and C-B Cross-Couplings via C-N and C-O Bond Activation.

• DOI: 10.1021/acscatal.0c05484
• 发表时间: 2021-02-05
• 期刊: ACS catalysis
• 影响因子: 12.9
• 作者: Xu J;Bercher OP;Talley MR;Watson MP
• 通讯作者: Watson MP