Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

在交叉偶联中利用烷基胺和烷基醇的行政补充

• 批准号: 10798396
• 负责人: Mary P Watson
• 金额: $ 8.61万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10798396
• 关键词: 14 year old; 3-Dimensional; Administrative Supplement; Alcohols; Amines; Awareness; Biological; Coupling; Deterioration; Development; Goals; High Pressure Liquid Chromatography; Liquid substance; Medicine; Methods; Parents; Performance; Public Health; Research; Research Support; drug development; enantiomer; human disease; instrument; programs

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.

摘要

项目成果

Stitching two chiral centers with one catalyst.

用一种催化剂缝合两个手性中心。

• DOI: 10.1126/science.aba4222
• 发表时间: 2020
• 期刊: Science (New York, N.Y.)
• 作者: Xu,Jianyu;Watson,MaryP
• 通讯作者: Watson,MaryP

Nickel-Catalyzed, Stereospecific C-C and C-B Cross-Couplings via C-N and C-O Bond Activation.

• DOI: 10.1021/acscatal.0c05484
• 发表时间: 2021-02-05
• 期刊: ACS catalysis
• 影响因子: 12.9
• 作者: Xu J;Bercher OP;Talley MR;Watson MP
• 通讯作者: Watson MP