Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling
Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling
批准号:
10798396
负责人:
Mary P Watson
金额:
$8.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-01 至 2024-05-31
关键词:
中文摘要
摘要
R35 GM131816的这一补充是针对购买岛津Nexera™超高
高效液相色谱仪高效测定有机化合物对映体过量
化合物。由于对映体具有不同的生物活性,因此需要有效的方法来研究
制备高对映体纯度的生物活性分子。认识到这一重要需要,制定
制备高手性有机化合物的新方法是母体研究的主要焦点
程序。拟议中的UHPLC仪将取代使用了14年的快速恶化的HPLC仪,后者已经
是支持R35支持的研究的关键主力工具。
英文摘要
ABSTRACT
This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High
Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic
compounds. Because of the differing biological activities of enantiomers, efficient methods are required to
prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of
new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research
program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has
been a critical workhorse instrument to enable the R35-supported research.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Stitching two chiral centers with one catalyst.
用一种催化剂缝合两个手性中心。
DOI:
10.1126/science.aba4222
发表时间:
2020
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
[Xu,Jianyu, Watson,MaryP]
通讯作者:
Watson,MaryP
DOI:
10.1021/acscatal.0c05484
发表时间:
2021-02-05
期刊:
ACS catalysis
影响因子:
12.9
作者:
[Xu J, Bercher OP, Talley MR, Watson MP]
通讯作者:
Watson MP
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
-
批准号:10728392
-
项目类别:
-
资助金额:$1.61万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
-
批准号:10617925
-
项目类别:
-
资助金额:$5.97万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling
-
批准号:10436560
-
项目类别:
-
资助金额:$4.82万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
-
批准号:10412949
-
项目类别:
-
资助金额:$38.56万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
-
批准号:10166874
-
项目类别:
-
资助金额:$38.56万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
-
批准号:10620171
-
项目类别:
-
资助金额:$38.56万
-
财政年份:2019
-
负责人:Mary P Watson
-
依托单位:
Cross Couplings of Amine and Alcohol Derivatives to Give Enantioenriched Products
-
批准号:8766156
-
项目类别:
-
资助金额:$28.79万
-
财政年份:2014
-
负责人:Mary P Watson
-
依托单位:
Cross Couplings of Amine and Alcohol Derivatives to Give Enantioenriched Products
-
批准号:9021912
-
项目类别:
-
资助金额:$10.6万
-
财政年份:2014
-
负责人:Mary P Watson
-
依托单位:
Catalytic, Asymmetric Aziridination using (Salen)metal Catalysts
-
批准号:7383897
-
项目类别:
-
资助金额:$4.68万
-
财政年份:2007
-
负责人:Mary P Watson
-
依托单位:
Catalytic, Asymmetric Aziridination using (Salen)metal Catalysts
-
批准号:7275202
-
项目类别:
-
资助金额:$4.48万
-
财政年份:2007
-
负责人:Mary P Watson
-
依托单位:
Catalytic, Asymmetric Aziridination using (Salen)metal Catalysts
-
批准号:7619478
-
项目类别:
-
资助金额:$1.8万
-
财政年份:2007
-
负责人:Mary P Watson
-
依托单位:
海外基金