Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

摘要 R35 GM131816 的此补充材料旨在购买 Shimadzu Nexera™ Ultra High 高效液相色谱仪 (UHPLC)，用于有效测定对映体过量的有机物 化合物。由于对映体的生物活性不同，需要有效的方法来 制备高对映体纯度的生物活性分子。认识到这一重要需求，开发 制备高度对映体富集的有机化合物的新方法是母公司研究的主要焦点 程序。拟议的 UHPLC 仪器将取代使用了 14 年、迅速老化的 HPLC，该仪器已 是 R35 支持的研究的关键主力仪器。

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.