Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

摘要 本R35 GM131816的补充旨在购买Shimadzu Nexera™超高 高效液相色谱法（UHPLC）用于有机化合物对映体过量的高效测定 化合物.由于对映异构体的生物活性不同，需要有效的方法来 制备高对映体纯度的生物活性分子。认识到这一重要需求， 制备高对映体富集的有机化合物的新方法是母体研究的一个主要焦点 程序.拟议的UHPLC仪器将取代迅速恶化的14岁的HPLC， 是一个关键的主力工具，使R35支持的研究。

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.