Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

摘要 R35 GM131816的这一补充是针对购买岛津Nexera™超高 高效液相色谱仪高效测定有机化合物对映体过量 化合物。由于对映体具有不同的生物活性，因此需要有效的方法来研究 制备高对映体纯度的生物活性分子。认识到这一重要需要，制定 制备高手性有机化合物的新方法是母体研究的主要焦点 程序。拟议中的UHPLC仪将取代使用了14年的快速恶化的HPLC仪，后者已经 是支持R35支持的研究的关键主力工具。

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.