课题基金 / 基金详情

Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling
在交叉偶联中利用烷基胺和烷基醇的补充
批准号:
10436560
负责人:
Mary P Watson
金额:
$4.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-01 至 2024-05-31

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中文摘要
翻译
此次对R35 GM131816的补充重点是开发一系列新的脱胺剂
英文摘要
This supplement to R35 GM131816 is focused on the development of a series of new deaminative cross-couplings and the training of graduate student Bria Garcia, in line with the goals of PA-21- 071. The scientific goals of this supplement are to develop (1) reductive cross-electrophile couplings of alkylpyridinium salts and (hetero)aryl chlorides, and (2) cascade cyclizations of alkylpyridinium salts tethered to alkenes to deliver a range of cyclic products. Both these reactions transform readily available starting materials into valuable motifs found in bioactive molecules. This research will hone Ms. Garcia’s expertise in catalytic method development. It will also greatly enhance her research capabilities by giving her experiences in high-throughput experimentation (HTE), collaborative interactions and insight with medicinal chemists at Pfizer, Inc., and proficiency in developing stereoselective transformations. This supplement proposal also includes a mentoring plan, including participation in UD’s Chemistry-Biology Interface program, multiple courses and workshops, teaching and mentoring experience, and professional networking opportunities, to maximize Ms. Garcia’s training and future success.
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Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
  • 批准号:
    10728392
  • 项目类别:
  • 资助金额:
    $1.61万
  • 财政年份:
    2019
  • 负责人:
    Mary P Watson
  • 依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
  • 批准号:
    10617925
  • 项目类别:
  • 资助金额:
    $5.97万
  • 财政年份:
    2019
  • 负责人:
    Mary P Watson
  • 依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
  • 批准号:
    10412949
  • 项目类别:
  • 资助金额:
    $38.56万
  • 财政年份:
    2019
  • 负责人:
    Mary P Watson
  • 依托单位:
Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling Reactions
  • 批准号:
    10166874
  • 项目类别:
  • 资助金额:
    $38.56万
  • 财政年份:
    2019
  • 负责人:
    Mary P Watson
  • 依托单位:
海外基金