Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

这是R35 GM131816的补充，重点开发了一系列新的脱氨剂 交叉耦合和研究生Bria Garcia的培训，符合PA-21的目标- 071.本附录的科学目标是开发(1)还原交叉亲电泳体 烷基吡啶盐和(杂)芳基氯化物的偶联，以及(2) 与烯烃相连的烷基吡啶盐可提供一系列环状产物。这两种反应 将容易获得的起始材料转化为生物活性分子中的有价值的主题。 这项研究将磨练加西亚女士在催化方法开发方面的专业知识。也将极大地 通过提供她在高通量实验方面的经验来增强她的研究能力 (HTE)、与辉瑞公司的药物化学家的协作互动和洞察，以及 熟练开发立体选择性转换。这份补充提案还包括 一项指导计划，包括参加UD的化学-生物学接口计划，多次 课程和研讨会、教学和指导经验以及专业网络 最大限度地扩大加西亚女士的培训和未来成功的机会。

This supplement to R35 GM131816 is focused on the development of a series of new deaminative cross-couplings and the training of graduate student Bria Garcia, in line with the goals of PA-21- 071. The scientific goals of this supplement are to develop (1) reductive cross-electrophile couplings of alkylpyridinium salts and (hetero)aryl chlorides, and (2) cascade cyclizations of alkylpyridinium salts tethered to alkenes to deliver a range of cyclic products. Both these reactions transform readily available starting materials into valuable motifs found in bioactive molecules. This research will hone Ms. Garcia’s expertise in catalytic method development. It will also greatly enhance her research capabilities by giving her experiences in high-throughput experimentation (HTE), collaborative interactions and insight with medicinal chemists at Pfizer, Inc., and proficiency in developing stereoselective transformations. This supplement proposal also includes a mentoring plan, including participation in UD’s Chemistry-Biology Interface program, multiple courses and workshops, teaching and mentoring experience, and professional networking opportunities, to maximize Ms. Garcia’s training and future success.