Countermeasures to cardiovascular impairment during circadian misalignment

昼夜节律失调期间心血管损害的对策

• 批准号: 10802104
• 负责人: Sophie Seward
• 金额: $ 3.57万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-26 至 2024-08-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10802104
• 关键词: Abdomen; Achievement; Acute; Adult; Behavior; Behavioral; Biological; Blood Pressure; Blood Vessels; Calories; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Chronic Disease; Circadian Dysregulation; Circadian Rhythms; Circadian desynchrony; Clinical; Consumption; Cross-Over Studies; Data; Development; Diastolic blood pressure; Diet; Disease Management; Eating; Energy Intake; Environmental Risk Factor; Fasting; Fatty acid glycerol esters; Forearm; Functional disorder; Funding; Future; Glucose; Goals; Healthcare; Heart Rate; Hour; Hypertension; Impairment; Individual; Inpatients; Insulin Resistance; International; Intervention; Jet Lag Syndrome; Knowledge; Laboratories; Light; Link; Lipids; Measures; Mediating; Medical Residency; Mentorship; Metabolic; Metabolic Diseases; Methodology; Military Personnel; Modernization; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Obesity; Paramedical Personnel; Persons; Physiology; Pilot Projects; Plasma; Police; Population; Populations at Risk; Prediabetes syndrome; Protocols documentation; Publications; Randomized; Research; Research Design; Risk; Risk Factors; Rotation; Savings; Scientist; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Societies; System; Testing; Time; Time-restricted feeding; Training; Visual; Visualization; Weight Gain; Woman; Work; blood pressure elevation; cardiometabolism; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; circadian; combat; cost effective; diabetes risk; disorder prevention; disorder risk; emergency service responder; fasting glucose; fire fighter; high risk; improved; intrahepatic; meetings; men; prevent; programs; reactive hyperemia; research and development; response; risk mitigation; shift work; skills; translatable strategy; vasoconstriction

PROJECT SUMMARY People who work evening, night or rotating shifts (i.e. “nonstandard” work hours) make up 20% of the US workforce, have a 17% higher risk of cardiovascular disease (CVD) compared to people who work days. Sleep and circadian misalignment are two mechanism suggested to increases the risk of CVD in people who work non-standard hours, and is highly prevalent and often unavoidable in modern, 24-hour society (e.g. shift work, long work hours, jet lag, medical residency, emergency responders, military personnel, Daylight Savings Time changes, etc). Disruptions in sleep and circadian rhythms have been linked to insulin resistance, increased energy intake, weight gain, and increased total body, abdominal and intrahepatic fat content, yet there have been limited attempts at identifying strategies or countermeasures to prevent the impact of such disruption on CVD risk in a sizeable proportion of the population. Therefore, our long-term goal is to identify and develop effective, behavioral countermeasures to combat the increased risk for metabolic diseases associated with sleep and circadian disruption when these behaviors are unavoidable. The overall objective for this project is to test the impact of time-restricted feeding to a 7h period in the day as a noninvasive countermeasure to the metabolic impairments associated with circadian misalignment. Our central hypothesis is that time-restricted feeding to the daytime period will prevent cardiovascular impairments during circadian misalignment compared to a condition where energy is consumed throughout the day and night. The rationale for the proposed project is that defining a non-invasive, scalable and feasible countermeasure to circadian misalignment could mitigate the risk of cardiovascular disease. To test our overall hypothesis, will use a randomized crossover study with a rigorous inpatient diet-, activity and light-controlled protocol in 32 healthy men and women. We will determine the impact of time- restricted feeding during circadian misalignment on 1) 24h blood pressure; and 2) vascular function. Findings from this study represent a critical advancement in the fields of translational circadian and metabolic physiology by identifying and testing a countermeasure to circadian misalignment. Achievement of our proposed aims could lead to the development of new intervention strategies for chronic disease prevention and management. The knowledge to be gained offers the potential to support cost-effective programs that may inform our healthcare approach to cardiovascular disease prevention in populations at risk for these diseases such as shift workers, individuals with sleep disorders and anyone who eats outside of daytime hours.

项目摘要 晚班、夜班或轮班（即“非标准”工作时间）的人占20%， 美国劳动力，有17%的心血管疾病（CVD）的风险高出工作日的人相比。 睡眠和昼夜节律失调是两种机制，建议增加心血管疾病的风险， 非标准工作时间，在现代24小时社会中非常普遍，而且往往是不可避免的（例如轮班 工作，长时间工作，时差，医疗住院医师，紧急救援人员，军事人员，夏令时 时间变化等）。睡眠和昼夜节律的紊乱与胰岛素抵抗有关， 增加能量摄入，体重增加，增加全身，腹部和肝内脂肪含量，但 在确定防止这种影响的战略或对策方面， 在相当大比例的人群中，心血管疾病风险受到破坏。 因此，我们的长期目标是确定和制定有效的行为对策， 与睡眠和昼夜节律紊乱相关的代谢疾病的风险增加作斗争， 行为不可避免。本项目的总体目标是测试限时喂养的影响 作为一种非侵入性的对策，与代谢障碍相关的 昼夜节律失调我们的中心假设是，限制时间喂养到白天将防止 与消耗能量的情况相比， 在白天和黑夜。提出该项目的理由是，定义一个非侵入性的，可扩展的 对昼夜节律失调采取可行的对策可以降低心血管疾病的风险。 为了检验我们的总体假设，将使用一项随机交叉研究，采用严格的住院饮食， 活动和光控制协议在32名健康男性和女性。我们将确定时间的影响- 在昼夜节律失调期间限制进食，1）24小时血压;和2）血管功能。 这项研究的发现代表了翻译昼夜节律和 代谢生理学通过识别和测试昼夜节律失调的对策。实现 我们提出的目标可能会导致新的慢性病预防干预策略的发展 和管理获得的知识提供了支持具有成本效益的方案的潜力， 告知我们的医疗保健方法，以预防这些疾病的风险人群中的心血管疾病 例如轮班工人、睡眠障碍者以及在白天以外时间进食的人。