Unraveling the molecular connections that link circadian rhythms and lipid metabolism

揭示昼夜节律和脂质代谢之间的分子联系

• 批准号: 10806342
• 负责人: XUEMIN WANG
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF MISSOURI-ST. LOUIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-10 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10806342
• 关键词: Administrative Supplement; Biochemical; Circadian Rhythms; Data Analyses; Environment; Experimental Designs; Future; Health; Learning; Link; Medical; Molecular; Molecular Probes; Process; Research; Schools; Science; Students; Testing; career; circadian pacemaker; experience; experimental study; lipid metabolism; molecular clock; student athlete; summer research; undergraduate student

SUMMARY: This Administrative Supplement requests support for Brooklyn Messenger, an undergraduate student to gain summer research experience. Brooklyn is considering pursuing a health-related science career. She has had some opportunities to shadow and explore the medical field but none with research. As a student athlete, she does not have as many opportunities with research during the school year. In the summer, she will conduct experiments in a project to probe the molecular interconnections between the molecular clock and lipid metabolism. She will learn the process of proposing a specific scientific hypothesis, designing experiments to test it, interpreting data, and making scientific presentation. These activities in gaining research experience in a cutting-edge scientific environment will enhance her understanding of scientific research and help Brooklyn determine her future career pursuits.

摘要：本行政补充请求支持Brooklyn Messenger， 本科生获得暑期研究经验。布鲁克林正在考虑 与健康相关的科学职业。她有一些机会去跟踪和探索 医学领域，但没有研究。作为一名学生运动员，她没有那么多 在学年中进行研究的机会。在夏天，她将进行 在一个项目中的实验，以探测分子钟之间的分子互连 和脂质代谢。她将学习提出一个具体的科学假设的过程， 设计实验来测试它，解释数据，并进行科学演示。这些 在尖端科学环境中获得研究经验的活动将提高 她对科学研究的理解，并帮助布鲁克林确定她未来的职业生涯 追求

项目成果

Phospholipase Dδ and phosphatidic acid mediate heat-induced nuclear localization of glyceraldehyde-3-phosphate dehydrogenase in Arabidopsis.

• DOI: 10.1111/tpj.15981
• 发表时间: 2022-11
• 期刊: PLANT JOURNAL
• 影响因子: 7.2
• 作者: Kim, Sang-Chul;Yao, Shuaibing;Zhang, Qun;Wang, Xuemin
• 通讯作者: Wang, Xuemin

COLD REGULATED GENE 27 and 28 antagonize the transcriptional activity of the RVE8/LNK1/LNK2 circadian complex.

• DOI: 10.1093/plphys/kiad210
• 发表时间: 2023-07-03
• 期刊: PLANT PHYSIOLOGY
• 影响因子: 7.4
• 作者: Sorkin, Maria L.;Tzeng, Shin-Cheng;King, Stefanie;Romanowski, Andres;Kahle, Nikolai;Bindbeutel, Rebecca;Hiltbrunner, Andreas;Yanovsky, Marcelo J.;Evans, Bradley S.;Nusinow, Dmitri A.
• 通讯作者: Nusinow, Dmitri A.

Phosphate Deficiency Modifies Lipid Composition and Seed Oil Production in Camelina.

• DOI: 10.1016/j.plantsci.2023.111636
• 发表时间: 2023-02
• 期刊: Plant science : an international journal of experimental plant biology
• 作者: Jianwu Li;Yuan Su;C. Shapiro;D. Schachtman;Xuemin Wang

Monitoring lipid-protein interactions in planta using Förster resonance energy transfer.

使用福斯特共振能量转移监测植物中的脂质-蛋白质相互作用。

• DOI: 10.1016/bs.mie.2022.08.040
• 发表时间: 2023
• 期刊: Methods in enzymology
• 作者: Yao,Shuaibing;Wang,Xuemin
• 通讯作者: Wang,Xuemin