Metabolic Basis of Disease

疾病的代谢基础

• 批准号: 10802182
• 负责人: Jacqueline M Stephens
• 金额: $ 23.92万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10802182
• 关键词: Animal Behavior; Animal Model; Anxiety; Biomedical Research; Cellular biology; Centers of Research Excellence; Chronic Disease; Collaborations; Comparative Biology; Diabetes Mellitus; Disease; Eating; Faculty; Fostering; Genomics; Goals; Growth; Health; Human; Infrastructure; Longevity; Malignant Neoplasms; Mentors; Metabolic; Mission; Molecular; Pre-Eclampsia; Research; Research Project Grants; Research Support; Talents; Tissues; Transgenic Mice; bioimaging; improved; innovation; interest; pre-clinical research

Project Summary: The overall goal of this new center is to facilitate the growth of young intellectual talent and build the scientific infrastructure that will promote biomedical research discoveries that will enhance our understanding of the metabolic aspects of different diseases. Specifically, we have identified four junior faculty with research interests in different, but complementary aspects of disease research. Each Research Project focuses on the metabolic aspect of a disease (anxiety/food intake, diabetes, cancer, and preeclampsia). Despite the diversity in tissues and diseases of interest, each project strongly fits into Pennington Biomedical’s general mission, to discover the triggers of chronic diseases through innovative research that improves human health across the lifespan. Within this Metabolic Basis of Disease (MBD) COBRE proposal, we are developing two new scientific cores. The first is a Preclinical Research Core, which brings together strengths of our current Comparative Biology Core, Animal Models and Behavior Core, and Transgenics Mouse Core. The second new core is a Molecular Mechanisms core that will integrate aspects of our Genomic Cores and Cell Biology Bioimaging Core to provide mentoring and technical support for the Research Project PIs and PBRC faculty.

项目概要： 这个新中心的总体目标是促进青年智力人才的成长， 基础设施，这将促进生物医学研究的发现，这将提高我们的理解， 不同疾病的代谢方面。具体来说，我们已经确定了四个初级教师的研究兴趣， 在疾病研究的不同但互补的方面。每个研究项目都侧重于代谢 疾病的一个方面（焦虑/食物摄入、糖尿病、癌症和先兆子痫）。尽管组织的多样性 和感兴趣的疾病，每个项目都非常符合彭宁顿生物医学的一般使命，以发现 通过创新研究，改善人类的健康在整个生命周期的触发慢性疾病。内 在这个疾病代谢基础（MBD）COBRE提案中，我们正在开发两个新的科学核心。第一 是一个临床前研究核心，它汇集了我们目前的比较生物学核心，动物 模型和行为核心，和转基因小鼠核心。第二个新核心是分子机制 核心，将整合我们的基因组核心和细胞生物学生物成像核心的各个方面，以提供指导 为研究项目PI和PBRC教师提供技术支持。

项目成果

Cardiometabolic Phenotypic Differences in Male Offspring Born to Obese Preeclamptic-Like BPH/5 Mice.

• DOI: 10.3389/fped.2021.636143
• 发表时间: 2021
• 期刊: Frontiers in pediatrics
• 影响因子: 2.6
• 作者: Beckers KF;Gomes VCL;Crissman KJR;Adams DM;Liu CC;Del Piero F;Butler SD;Sones JL
• 通讯作者: Sones JL

Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones.

• DOI: 10.3390/reprodmed3040021
• 发表时间: 2022-12
• 期刊: Reproductive medicine (Basel, Switzerland)
• 作者: Gomes VCL;Woods AK;Crissman KR;Landry CA;Beckers KF;Gilbert BM;Ferro LR;Liu CC;Oberhaus EL;Sones JL
• 通讯作者: Sones JL

Sex-specific effects of maternal weight loss on offspring cardiometabolic outcomes in the obese preeclamptic-like mouse model, BPH/5.

• DOI: 10.14814/phy2.15444
• 发表时间: 2022-09
• 期刊: Physiological reports
• 影响因子: 2.5

Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity.

母体糖尿病和肥胖引起的小鼠内脏蛋黄囊中异常脂质积累。

• DOI: 10.3389/fcell.2023.1073807
• 发表时间: 2023
• 期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
• 影响因子: 5.5
• 作者: Zhang, Man;Salbaum, J. Michael;Jones, Sydney;Burk, David;Kappen, Claudia
• 通讯作者: Kappen, Claudia

The BPH/5 Mouse Model of Superimposed Preeclampsia Is Not a Model of HELLP Syndrome.

• DOI: 10.3390/biology10111179
• 发表时间: 2021-11-14
• 期刊: Biology
• 影响因子: 4.2
• 作者: Johnston AN;Batts TL;Langohr IM;Moeller C;Liu CC;Sones JL
• 通讯作者: Sones JL