Metabolic Basis of Disease

项目摘要： 这个新中心的总体目标是促进青年智力人才的成长， 基础设施，这将促进生物医学研究的发现，这将提高我们的理解， 不同疾病的代谢方面。具体来说，我们已经确定了四个初级教师的研究兴趣， 在疾病研究的不同但互补的方面。每个研究项目都侧重于代谢 疾病的一个方面（焦虑/食物摄入、糖尿病、癌症和先兆子痫）。尽管组织的多样性 和感兴趣的疾病，每个项目都非常符合彭宁顿生物医学的一般使命，以发现 通过创新研究，改善人类的健康在整个生命周期的触发慢性疾病。 在这个疾病代谢基础（MBD）COBRE提案中，我们正在开发两个新的科学核心。的 首先是临床前研究核心，它汇集了我们目前比较生物学核心的优势， 动物模型和行为核心，和转基因小鼠核心。第二个新的核心是一个分子 机制核心，将整合我们的基因组核心和细胞生物学生物成像核心的各个方面， 为研究项目PI和PBRC教师提供指导和技术支持。

Project Summary: The overall goal of this new center is to facilitate the growth of young intellectual talent and build the scientific infrastructure that will promote biomedical research discoveries that will enhance our understanding of the metabolic aspects of different diseases. Specifically, we have identified four junior faculty with research interests in different, but complementary aspects of disease research. Each Research Project focuses on the metabolic aspect of a disease (anxiety/food intake, diabetes, cancer, and preeclampsia). Despite the diversity in tissues and diseases of interest, each project strongly fits into Pennington Biomedical’s general mission, to discover the triggers of chronic diseases through innovative research that improves human health across the lifespan. Within this Metabolic Basis of Disease (MBD) COBRE proposal, we are developing two new scientific cores. The first is a Preclinical Research Core, which brings together strengths of our current Comparative Biology Core, Animal Models and Behavior Core, and Transgenics Mouse Core. The second new core is a Molecular Mechanisms core that will integrate aspects of our Genomic Cores and Cell Biology Bioimaging Core to provide mentoring and technical support for the Research Project PIs and PBRC faculty.