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Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications

Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications
多细胞和多尺度系统建模,以了解跨学科应用中人体免疫系统的动态
批准号:
10799092
负责人:
Tomas Helikar
金额:
$24.74万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-01 至 2026-11-30

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Project Summary The parent grant, 2R35GM119770, (“Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications”) supports my research program, which aims to identify how the immune system can be rewired en masse to elicit higher-order decision-making while still enabling the system to remain otherwise “healthy.” To this end, we are leveraging a highly interdisciplinary research team (computational and experimental immunologists, software engineers, and education researchers) and collaborators to build a Virtual Immune System -- a multi-scale, multi-approach computational framework to understand better the complex dynamical nature of the immune system, identify more accurate multi-dimensional biomarkers, and identify safe and effective treatments within a reasonable time and cost. To this end, we have been building a comprehensive model of the immune system, that integrates knowledge and data across several scales of biological organization, including metabolism, gene regulation, signal transduction, and communication among the different types of immune cells. In addition to expanding the Virtual Immune system, my program continues to develop methods and technologies for data-driven model construction, visualization, computation, real-time simulations, and reproducibility to advance multi-scale modeling of the immune system and beyond, including a cloud-based collaborative modeling software, Cell Collective. This supplement will enable us to generate new high-quality data under consistent conditions that will be used to significantly improve the quality and accuracy of the Virtual Immune System model. The model, along with the data, will be made available to the community through our computing infrastructure.
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Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications
  • 批准号:
    10330815
  • 项目类别:
  • 资助金额:
    $37.13万
  • 财政年份:
    2016
  • 负责人:
    Tomas Helikar
  • 依托单位:
Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications
  • 批准号:
    10543785
  • 项目类别:
  • 资助金额:
    $37.13万
  • 财政年份:
    2016
  • 负责人:
    Tomas Helikar
  • 依托单位:
Software for collaborative construction, simulation, and analysis of mechanistic computational models of biological systems
  • 批准号:
    10609352
  • 项目类别:
  • 资助金额:
    $22.28万
  • 财政年份:
    2016
  • 负责人:
    Tomas Helikar
  • 依托单位:
A predictive multi-scale model of the immune system: An integrated computational resource for interdisciplinary applications.
  • 批准号:
    9142820
  • 项目类别:
  • 资助金额:
    $35.68万
  • 财政年份:
    2016
  • 负责人:
    Tomas Helikar
  • 依托单位:
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