Administrative Supplement for Peptide Synthesizer

肽合成仪行政补充

• 批准号: 10799004
• 负责人: Hippokratis Kiaris
• 金额: $ 20.6万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-10 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10799004
• 关键词: Administrative Supplement; Analgesics; Animals; Area; Centers of Research Excellence; Chemicals; Chemistry; DNA biosynthesis; Development; Disease; Drug Design; Equipment; Flow Cytometry; Funding; Future; Infrastructure; Lead; Libraries; Ligands; Microscopy; Molecular Target; Opioid Peptide; Peptide Library; Peptide Synthesis; Peptides; Pharmaceutical Preparations; Phase; Pilot Projects; Play; Process; Proteins; Research Personnel; Research Project Grants; Research Support; Resources; S phase; Science; Solid; South Carolina; Structure; Synthesis Chemistry; System; Technology; Training; Universities; Validation; cellular targeting; drug discovery; drug synthesis; drug-like compound; experience; functional genomics; instrument; multidisciplinary; next generation; peptidomimetics; professor; protein protein interaction; scale up; small molecule libraries; targeted treatment

The COBRE Center for Targeted Therapeutics (CTT) at the University of South Carolina (UofSC) supports research that seeks to develop new and more effective classes of drugs against various diseases, by aiming these drugs at molecular and cellular targets that play a key role in the disease. The Drug design and Synthesis Core provides access to synthetic chemistry and structure-based drug design resources, and these are a critical part of the drug discovery process. Many of the projects being pursued involve the targeting of protein-protein interactions and part of the target validation approach is to identify peptide ligands that represent starting points for application of strategies can convert these into more drug-like compounds. Another approach to drug discovery is the solid phase synthesis of DNA encoded chemical libraries which combined with the mix and split library approaches would allow significant chemical diversity to be generated. We seek to acquire a state-of-the-art solid phase synthesizer which can be used to generate libraries of peptides, peptidomimetics and other fragment-oriented compounds rapidly and efficiently through parallel synthesis. This will substantially increase the capabilities of the DDSC in early-stage drug discovery and support multiple projects currently underway or planned for the near future.

南卡罗来纳大学科布雷靶向治疗中心(CTT) 支持旨在开发针对各种疾病的新的、更有效的药物类别的研究 疾病，通过针对分子和细胞靶点，这些靶点在 疾病。药物设计和合成核心提供了对合成化学和 基于结构的药物设计资源，这些资源是药物发现过程的关键部分。 许多正在进行的项目涉及以蛋白质-蛋白质相互作用为目标，部分 目标验证方法的目的是确定代表以下物质的起点的多肽配体 策略的应用可以将这些转化为更多的类似药物的化合物。另一种方法是 药物发现是DNA编码的化学文库的固相合成 使用混合和裂解文库方法将允许显著的化学多样性 已生成。我们寻求获得一种最先进的固相合成器，它可以用于 快速生成多肽、多肽模拟物和其他面向片段的化合物的文库 并通过并行合成来高效地实现。这将大大提高 DDSC处于早期药物发现阶段，并支持目前正在进行或计划中的多个项目 在不久的将来。