Administrative Supplement for Peptide Synthesizer

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The COBRE Center for Targeted Therapeutics (CTT) at the University of South Carolina (UofSC) supports research that seeks to develop new and more effective classes of drugs against various diseases, by aiming these drugs at molecular and cellular targets that play a key role in the disease. The Drug design and Synthesis Core provides access to synthetic chemistry and structure-based drug design resources, and these are a critical part of the drug discovery process. Many of the projects being pursued involve the targeting of protein-protein interactions and part of the target validation approach is to identify peptide ligands that represent starting points for application of strategies can convert these into more drug-like compounds. Another approach to drug discovery is the solid phase synthesis of DNA encoded chemical libraries which combined with the mix and split library approaches would allow significant chemical diversity to be generated. We seek to acquire a state-of-the-art solid phase synthesizer which can be used to generate libraries of peptides, peptidomimetics and other fragment-oriented compounds rapidly and efficiently through parallel synthesis. This will substantially increase the capabilities of the DDSC in early-stage drug discovery and support multiple projects currently underway or planned for the near future.