Aging Symptom Trajectories in Mother Carriers of the FMR1 Premutation

FMR1 前突变母携带者的衰老症状轨迹

• 批准号: 10813530
• 负责人: Jessica Klusek
• 金额: $ 1.08万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10813530
• 关键词: Acceleration; Adopted; Age; Aging; Child; Child Rearing; FMR1 Premutation; Fragile X Syndrome; Future; Genes; Goals; Health; Mental Health; Molecular Abnormality; Molecular Genetics; Mothers; Mutate; Neurodegenerative Disorders; Parents; Phenotype; Premature Menopause; Research; Risk; Risk Factors; Science; Stress; Symptoms; Woman; Work; age related; career; disorder risk; experience; high school; human old age (65+); improved outcome; interest; longitudinal design; middle age; mutation carrier; social; social deficits

PROJECT SUMMARY/ABSTRACT About 1 in 151 women in the US are carriers of a genetic abnormality called the FMR1 premutation (FXpm). Mothers who carry the FXpm are at risk for passing the mutated gene to their children, which may result in fragile X syndrome. The FXpm is also associated with substantially increased risk for disease, including neurodegenerative disease, premature menopause, psychiatric involvement, and executive and social deficits. The parent R01 seeks to determine the stability of key FXpm phenotypes (mental health, executive, social) across midlife and early old age in FXpm carrier mothers compared to healthy controls (Aim 1); investigate autonomic and molecular-genetic factors associated with age-related symptom expression and their interface with parenting stress (Aim 2); and evaluate functional limitations associated with FXpm symptoms across age (Aim 3). We will accomplish these aims by adopting an accelerated longitudinal design to track age-related change occurring across 45-80 years in 75 FXpm carrier mothers compared to 75 control mothers. The over- arching goal is to inform the critical age periods and risk factors in age-related decline, as well as to lay the groundwork for future mechanistic studies. This work is necessary to develop strategies to ameliorate FXpm symptoms, which will improve outcomes for both FXpm carrier mothers and their children with fragile X syndrome. This diversity supplement application will support Ms. Ariyo, a promising high school scholar, to obtain meaningful experience in health-related research to stimulate interest in research careers in science.

项目总结/文摘