The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African Xhosa

祖先群体网络表型协调工作组行政补充：南非科萨人精神分裂症的 2/3 基因组学

• 批准号: 10817967
• 负责人: Ezra S. Susser
• 金额: $ 2.79万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10817967
• 关键词: Acceleration; Administrative Supplement; African ancestry; Anhedonia; Asian; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Discrimination; Equipment and supply inventories; Equity; Florida; Genetic; Genomics; Goals; Individual; Latin American; Measurement; Measures; Mental Health; Mental disorders; National Institute of Mental Health; Obsessive compulsive behavior; Phenotype; Population; Procedures; Process; Public Health; Reproducibility; Research; Resources; Schizophrenia; Severities; Site; South African; Standardization; Suicide; Symptoms; System; Underrepresented Populations; cognitive function; cohort; data archive; data sharing; disease phenotype; instrument; member; phenotypic data; pleasure; social stigma; suicidal; working group

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries. SUMMARY AND CONNECTION BETWEEN THE APN AND THIS SUPPLEMENT The Ancestral Populations Network (APN) was established by the National Institutes of Mental Health (PAR-20- 026 and PAR-20-027) with overarching goals of (a) accelerating genetic discovery for psychiatric disorders in cohorts of non-European ancestry, (b) advancing global mental health discovery and equity, and (c) facilitating measure and data analytic harmonization efforts across members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. This supplement will implement validated measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma across ongoing studies within the APN. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目摘要 该项目实现了祖先人口网络的主要目标（APN； PAR-20-026和PAR-20-- 027），即促进APN成员之间的测量和数据分析协调工作以增强 严格且可重复性，并为网络成员和科学界创造资源。通过一个 APN成员的共识过程，Anhedonia的测量，认知，强迫症症状， 在正在进行的研究中选择自杀和歧视/污名来协调。这些 将在代表亚洲，拉丁语的估计27,500个人中收集统一的措施 美国和非洲祖先跨越了15个国家。 APN与此补充之间的摘要和联系 祖先人口网络（APN）由美国国立心理健康研究所（Par-20-- Par-20- 026和PAR-20-027）具有（a）加速遗传发现精神疾病的总体目标 非欧洲血统的人群，（b）促进全球心理健康发现和公平，（c）促进 衡量成员之间的衡量和数据分析协调工作，以增强严格性和可重复性以及 为网络成员和科学界生成资源。该补充将实施 经过验证的痛苦，认知，强迫症症状，自杀性和 APN内正在进行的研究中的歧视/污名。这些统一的措施将被收集 估计代表亚洲，拉丁美洲和非洲祖先的27,500个人 超过15个国家。