The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African Xhosa

祖先群体网络表型协调工作组行政补充：南非科萨人精神分裂症的 2/3 基因组学

• 批准号: 10817967
• 负责人: Ezra S. Susser
• 金额: $ 2.79万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10817967
• 关键词: Acceleration; Administrative Supplement; African ancestry; Anhedonia; Asian; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Discrimination; Equipment and supply inventories; Equity; Florida; Genetic; Genomics; Goals; Individual; Latin American; Measurement; Measures; Mental Health; Mental disorders; National Institute of Mental Health; Obsessive compulsive behavior; Phenotype; Population; Procedures; Process; Public Health; Reproducibility; Research; Resources; Schizophrenia; Severities; Site; South African; Standardization; Suicide; Symptoms; System; Underrepresented Populations; cognitive function; cohort; data archive; data sharing; disease phenotype; instrument; member; phenotypic data; pleasure; social stigma; suicidal; working group

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries. SUMMARY AND CONNECTION BETWEEN THE APN AND THIS SUPPLEMENT The Ancestral Populations Network (APN) was established by the National Institutes of Mental Health (PAR-20- 026 and PAR-20-027) with overarching goals of (a) accelerating genetic discovery for psychiatric disorders in cohorts of non-European ancestry, (b) advancing global mental health discovery and equity, and (c) facilitating measure and data analytic harmonization efforts across members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. This supplement will implement validated measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma across ongoing studies within the APN. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目摘要 该项目实现了祖先人口网络（APN; PAR-20-026和PAR-20- 027）的一个主要目标。 027），即促进APN成员之间的测量和数据分析协调工作， 严谨性和可重复性，并为网络成员和科学界提供资源。通过 APN成员的共识过程，快感缺乏，认知，强迫症状， 自杀倾向和歧视/污名被选择用于协调正在进行的研究。这些 将在代表亚洲、拉丁美洲和加勒比地区的大约27，500名个人中收集统一的测量数据， 美国和非洲血统跨越15个国家。 APN和本协议之间的总结和联系 祖先人口网络（APN）是由美国国家精神卫生研究院（PAR-20- 2000）建立的。 026和PAR-20-027），其总体目标是（a）加速精神疾病的遗传发现， 非欧洲血统的群体，（B）推进全球精神卫生发现和公平，以及（c）促进 成员之间的测量和数据分析协调工作，以提高严谨性和可重复性， 为网络成员和科学界提供资源。该补充将实施 快感缺失、认知、强迫症状、自杀倾向和 歧视/污名在APN内正在进行的研究。这些统一的措施将被收集 据估计，27，500人代表亚洲，拉丁美洲和非洲血统， 超过15个国家。